DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPH93 and PRSS21

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_006790.1	Gene:	PRSS21 / 10942	HGNCID:	9485	Length:	314	Species:	Homo sapiens

Alignment Length:	288	Identity:	82/288 - (28%)
Similarity:	131/288 - (45%)	Gaps:	60/288 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LSPSCGMSNANGLQMVEGITIDQARPAQYPWAVAIFHNGQYLAGGSLIQPNVVLTVAHRVITIET 293
            ||..||...... ::|.|   :.|...::||..::.....::.|.||:.....||.||   ..||
Human    29 LSGPCGRRVITS-RIVGG---EDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAH---CFET 86

  Fly   294 ---------------ELVVRAGDWDLKS------DREIFLSEQREVERAVIHEGFDFKSGANNLA 337
                           :|......|.|::      ...|:||     .|.:.:..:|       :|
Human    87 YSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLS-----PRYLGNSPYD-------IA 139

  Fly   338 LLFLNSPFKLNDHIRTICLPTPNKSFAGRR-CTVAGWGKMRYEDQRYST--VLKKVQLLVVNRNV 399
            |:.|::|.....||:.|||......|..|. |.|.|||.:: ||:...:  .|::||:.::|.::
Human   140 LVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK-EDEALPSPHTLQEVQVAIINNSM 203

  Fly   400 CEKFLRSTRLGAKFELPKNI----ICAG-GELGRDTCTGDGGSALFCSIGGENSGVYEQAGIVNW 459
            |      ..|..|:...|:|    :||| .:.|:|.|.||.|..|.|:    .:|::.|.|:|:|
Human   204 C------NHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACN----KNGLWYQIGVVSW 258

  Fly   460 GVGCGQEGIPAIYTEVSKFTNWITEKLL 487
            |||||:...|.:||.:|....|| :||:
Human   259 GVGCGRPNRPGVYTNISHHFEWI-QKLM 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089
		Tryp_SPc	250..485	CDD:238113	74/263 (28%)
		Tryp_SPc	252..482	CDD:214473	72/258 (28%)
PRSS21	NP_006790.1	Tryp_SPc	42..283	CDD:238113	76/270 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6434
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860