DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and si:dkey-32n7.7

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021335883.1	Gene:	si:dkey-32n7.7 / 108191692	ZFINID:	ZDB-GENE-121214-179	Length:	609	Species:	Danio rerio

Alignment Length:	481	Identity:	114/481 - (23%)
Similarity:	183/481 - (38%)	Gaps:	107/481 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TVLIEPNGPEDDKVGVNGINAQLSPTRELTRDRPNTIESQVKEIN--DFSGRPTNNERNPA-TEP 122
            |:.:..||                   :||.|:|      :.:.|  :|....|.:...|. |:.
Zfish   107 TIFVNNNG-------------------DLTFDKP------LHQYNPDNFPAYSTRDIIAPLWTDI 146

  Fly   123 NNG-----GYTTPNGGYPVNNGGYPVNNGGYPSNN----------------GGYPSNNGGYPV-- 164
            |||     .|.....|..:|.....:|. .:|:.|                .||..:...:.|
Zfish   147 NNGMEGTISYRQVTNGDILNRASKDINR-YFPNLNFSASWVFIATWDKVPYYGYRESESTFQVVL 210

  Fly   165 ---NNGGYPVNNGGY----PANNGGYPANNG----GYPTTNVGN-----PTNNGGNPTTNFGNPT 213
               ....:.:.:..|    .:...||..|..    ..|.::|.|     ..|..|.......|.:
Zfish   211 VSDKKRSFTLMHYDYITYTQSAESGYDTNGSTVFYSIPVSDVTNLPYTSNVNVKGRWVFRVDNSS 275

  Fly   214 NNGGNPTTNVGSSELLSPS---CG---MSNANGLQMVEGITIDQARPAQYPWAVAIF-HNGQYLA 271
            ...|: ..|..|..|.|||   ||   ::::||  .|.|   ..:....:||..::: ::|| ..
Zfish   276 EVKGS-CINTNSQALDSPSAAVCGIIPVNSSNG--TVGG---QNSSAVHWPWQASLYWYSGQ-TC 333

  Fly   272 GGSLIQPNVVLTVAHRVITIETE-----LVVRAGDWDLKSDREIFLSE-QREVERAVIHEGFDFK 330
            |||||....||:.||   ....:     |.|..|.   |:..:...|. .|.|:..:.|..::..
Zfish   334 GGSLINKEWVLSAAH---CFNGQRNGFYLTVILGP---KTQNKYDPSRISRSVKAVIKHPYYNPN 392

  Fly   331 SGANNLALLFLNSPFKLNDHIRTICLPTPNKSF-AGRRCTVAGWGKMRYEDQRYS-TVLKKVQLL 393
            :..|::||:.|:.|....|.||.:||......| :.....:..|..:.......| .:.::|::.
Zfish   393 TNDNDIALVRLSFPITFTDSIRPVCLAAEGSVFNSDTESWITTWRNISDGVPLPSPKIFQEVEVP 457

  Fly   394 VVNRNVCEKFLRSTRLGAKFELPKNIICAG-GELGRDTCTGDGGSALFCSIGGENSGVYEQAGIV 457
            |:....|      ..|.....:..|:|||| .:.|:|.|.||.|..:.    ...|.|:.|:|||
Zfish   458 VIGNRQC------NCLYGVGSITDNMICAGLLKEGKDLCQGDSGGPMV----SNQSSVWVQSGIV 512

  Fly   458 NWGVGCGQEGIPAIYTEVSKFTNWIT 483
            ::|.||.|...|.:||.||::..|||
Zfish   513 SFGSGCAQSEFPGVYTRVSRYQEWIT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089	11/81 (14%)
		Tryp_SPc	250..485	CDD:238113	67/244 (27%)
		Tryp_SPc	252..482	CDD:214473	64/239 (27%)
si:dkey-32n7.7	XP_021335883.1	NIDO	4..63	CDD:310601
		NIDO	141..272	CDD:322035	23/131 (18%)
		Tryp_SPc	309..537	CDD:238113	66/247 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840