DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dl and RELB

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_006500.2	Gene:	RELB / 5971	HGNCID:	9956	Length:	579	Species:	Homo sapiens

Alignment Length:	373	Identity:	151/373 - (40%)
Similarity:	209/373 - (56%)	Gaps:	64/373 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 APGQGPAVDGQQSLNYNGLPAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSI 74
            |||.||                              :|::.|||||..:.:||||||||||||||
Human   118 APGPGP------------------------------QPHLVITEQPKQRGMRFRYECEGRSAGSI 152

  Fly    75 PGVNSTPENKTYPTIEIVGYKG-RAVVVVSC-VTKDTPYRPHPHNLVGKEGCKKGVCTLEINSE- 136
            .|.:||..:||.|.||:....| |.|.|.:| |.||.|:|.|||:||||: |..|:|.:.:...
Human   153 LGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKD-CTDGICRVRLRPHV 216

  Fly   137 TMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQK 201
            :.|..|:|||||||:||:||||::.:.::.:||:..|.....|  .:|:|.||:|||.... :|:
Human   217 SPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQ--EVDMNVVRICFQASYR-DQQ 278

  Fly   202 GRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKN 264
            |:... :.||:|||::|||:  .|:|.|||:...|....|..::.|||:||.||||||.|
Human   279 GQMRR-MDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVF----- 337

  Fly   265 GQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDS 329
            .::.||...||...|||:|.||.||||.|..|:|.||..|.:.|:|.:|||.||.|||.|:|.|
Human   338 SRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEPLPFTYLPRD- 401

  Fly   330 GKHTFWNLHRHLKR-KPDEDLFQQIL---------RLDAKREVQPPTI 367
              |..:.:.:..|| .||      :|         .:::||..:.|.|
Human   402 --HDSYGVDKKRKRGMPD------VLGELNSSDPHGIESKRRKKKPAI 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	82/175 (47%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	49/100 (49%)
RELB	NP_006500.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		RelB_leu_zip	18..96	CDD:318422
		Leucine-zipper	40..68
		RHD-n_RelB	125..296	CDD:143646	82/175 (47%)
		RHD_dimer	304..400	CDD:318421	48/100 (48%)
		RelB_transactiv	403..579	CDD:292799	9/45 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	433..438		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8582
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.940