Protein Alignment dl and REL

DIOPT Version :9

• Sequence 1: NP_001286014.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_002899.1
• Gene: REL / 5966
• HGNCID: 9954
• Length: 619
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 189/558 - (33%)
• Similarity: 264/558 - (47%)
• Gaps: 77/558 - (13%)

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            ||::|.|||..:.:||||:|||||||||||.:||..|:|||:|:|:.|.|:..|.::.|||:.||
Human     8 PYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNYYGKGKVRITLVTKNDPY 72

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSH 176
            :||||:||||: |:.|....|...|.....|.||||:|||||:::.|:..|.:..::||......
Human    73 KPHPHDLVGKD-CRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIITRIKAGINPFNVPEKQ 136

  Fly   177 RFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFG 239
            .......|||.||||||||:..|. |..|:.||||||.||:|.:|  .::|.|||:.....:|.|
Human   137 LNDIEDCDLNVVRLCFQVFLPDEH-GNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVRG 200

  Fly   240 NTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKV 304
            ..:|.|||:||.|:||.|||.     .:.|||.|.|...|||:|.||.||||.| ...||||..|
Human   201 GDEIFLLCDKVQKDDIEVRFV-----LNDWEAKGIFSQADVHRQVAIVFKTPPY-CKAITEPVTV 259

  Fly   305 FIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILR-------------- 355
            .:|||||||...||::.|.|:|.:  |.|:.|   ..|::....|||::.:
Human   260 KMQLRRPSDQEVSESMDFRYLPDE--KDTYGN---KAKKQKTTLLFQKLCQDHVETGFRHVDQDG 319

  Fly   356 LDAKREVQPPT-------IEVIDLDTPKIDVQREIPSEMEFNHEESQQSEPALEQEQSVQQEQYT 413
            |:......|||       |.|...:.|:..:...|.....|      :.||.|....:|.:|..|
Human   320 LELLTSGDPPTLASQSAGITVNFPERPRPGLLGSIGEGRYF------KKEPNLFSHDAVVREMPT 378

  Fly   414 QEQSLQQEQYTQ----EQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTS 474
            ...|..:..|..    ...|.....:..|.......:..|..:........||....  ||.: |
Human   379 GVSSQAESYYPSPGPISSGLSHHASMAPLPSSSWSSVAHPTPRSGNTNPLSSFSTRT--LPSN-S 440

  Fly   475 DHIP--------EDMEAADAHAEAEAHRLRSEQEKEIDTIIDEKVRELEQLDLGQQLEPRPL--- 528
            ..||        .|:.|::|.....|           |.|:..:...:...||....:|..|
Human   441 QGIPPFLRIPVGNDLNASNACIYNNA-----------DDIVGMEASSMPSADLYGISDPNMLSNC 494

  Fly   529 ------TANDKITEWMKSSEIEQQVHEPSPTAEADVLD 560
                  |::|.:.|......:...:..||..:..|..|
Human   495 SVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRD 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	86/172 (50%)
		IPT_NFkappaB	225..326	CDD:238582	50/100 (50%)
REL	NP_002899.1	RHD-n_c-Rel	8..179	CDD:143649	86/172 (50%)
		RHD_dimer	187..282	CDD:292797	49/100 (49%)
		Nuclear localization signal. /evidence=ECO:0000255	290..295		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..437		4/39 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..593

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157542
Domainoid	1	1.000	171	1.000	Domainoid score	I3750
eggNOG	1	0.900	-	-		E1_2CMKZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm8582
orthoMCL	1	0.900	-	-		OOG6_105422
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.710