DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and NFKB2

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_016871767.1	Gene:	NFKB2 / 4791	HGNCID:	7795	Length:	1081	Species:	Homo sapiens

Alignment Length:	933	Identity:	227/933 - (24%)
Similarity:	357/933 - (38%)	Gaps:	270/933 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 APGQGPAVDGQQSLNYNGL--------PAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYEC 66
            :|.||  :||  .:.|:..        |.:...:.|..       ||:.|.|||..:..||||.|
Human   185 SPNQG--LDG--IIEYDDFKLNSSIVEPKEPAPETADG-------PYLVIVEQPKQRGFRFRYGC 238

  Fly    67 EGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTL 131
            ||.|.|.:||.:|....|||||::|..|:|.|.:.|..||...|.|.|.|:||||:..:.|:|.:
Human   239 EGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAV 303

  Fly   132 EINSETMRAVFSNLGIQCVKKKDIEAAL---KAREEIRVDPFKTGFSHRFQ----------PSSI 183
            .:..:.|.|.|:|||:..|.||::...:   ..|:.:|..|  .|.:...|          ...:
Human   304 SVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRP--QGLTEAEQRELEQEAKELKKVM 366

  Fly   184 DLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILL 246
            ||:.|||.|..|:.:.. |.|:.||.||:|:||.|.|:  .|:|.|.|:...:.:|.|..::.||
Human   367 DLSIVRLRFSAFLRASD-GSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLL 430

  Fly   247 CEKVAKEDISVRFFE-EKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRR 310
            |:||.|:||.|||:| ::||   |:|||||..||||||.||.|:||.||.:.|..|..||:||:|
Human   431 CDKVQKDDIEVRFYEDDENG---WQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKR 492

  Fly   311 PSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLDTP 375
            ...|..|::..|.|.|:                            ::.|.|||....:.:...:.
Human   493 KRGGDVSDSKQFTYYPL----------------------------VEDKEEVQRKRRKALPTFSQ 529

  Fly   376 KIDVQREI-----------------------PSEMEFNHEES--------------QQSEPALEQ 403
            .......:                       ||.:.::..:|              .|....:..
Human   530 PFGGGSHMGGGSGGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPS 594

  Fly   404 EQSVQQ--EQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAI 466
            ..|.::  |.....::.|.|....|...:..:|..:|     |.|           ||:|....:
Human   595 RDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNARL-----FGL-----------AQRSARALL 643

  Fly   467 DHLPDHTSDHIPEDMEAADAHAEAEAHR-LRSEQEKEIDT-----IIDEKVRELEQL-------- 517
            |:            ...|||.|.....| |.:.|::..||     ||..:...:||:
Human   644 DY------------GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQ 696

  Fly   518 DLG-----QQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVL-----------------D 560
            |||     ..|...||                   |....|.:..|:                 |
Human   697 DLGVVNLTNHLHQTPL-------------------HLAVITGQTSVVSFLLRVGADPALLDRHGD 742

  Fly   561 SALEIS-KADKTLDELLETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAP----LQVEDSFD 620
            ||:.:: :|.....|||..:.:.........:....::......|| ::.|:|    |.|:...:
Human   743 SAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLA-VRARSPECLDLLVDSGAE 806

  Fly   621 DAAT-----YTSLQIAFKNPVLIPMDDIMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMR- 679
            ..||     .|:|.:|.:      |:::...|..:::..          ..||::.....||:.
Human   807 VEATERQGGRTALHLATE------MEELGLVTHLVTKLR----------ANVNARTFAGNTPLHL 855

  Fly   680 ----PVPPVPPAILTIQ---YPPEEDKLPPLPPKRIRKQDSNAENRSIEAN-----------TVQ 726
                ..|.:...:|...   :...|:.|.|||.......||::|....:..           |..
Human   856 AAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCS 920

  Fly   727 TK---------PSTGESPLNKRLPPAPKNPNFN-----------TLPRQKKPGFFSKLFSRRKSK 771
            ||         .:|.|.||.   ||:|..|..:           .|...:..|.:::|..|...:
Human   921 TKVKTLLLNAAQNTMEPPLT---PPSPAGPGLSLGDTALQNLEQLLDGPEAQGSWAELAERLGLR 982

  Fly   772 PDLAQGQENSSILDSKANSREPS 794
                      |::|:...:..||
Human   983 ----------SLVDTYRQTTSPS 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	71/185 (38%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	49/101 (49%)
NFKB2	XP_016871767.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157536
Domainoid	1	1.000	116	1.000	Domainoid score	I5955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950