DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and NFKB1

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001369554.1	Gene:	NFKB1 / 4790	HGNCID:	7794	Length:	969	Species:	Homo sapiens

Alignment Length:	1044	Identity:	254/1044 - (24%)
Similarity:	398/1044 - (38%)	Gaps:	251/1044 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVG 93
            |...|.|:|..|.:   .||::|.|||..:..||||.|||.|.|.:||.:|....|:||.::|..
Human    28 PEVFQPQMALPTAD---GPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICN 89

  Fly    94 YKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAA 158
            |.|.|.|:|..||.......|.|:||||. |:.|:||:....:.|...|:||||..|.||.:...
Human    90 YVGPAKVIVQLVTNGKNIHLHAHSLVGKH-CEDGICTVTAGPKDMVVGFANLGILHVTKKKVFET 153

  Fly   159 LKAR-EEIRVDPFKTGF-----------------------------SHRFQPSSIDLNSVRLCFQ 193
            |:|| .|..:..:..|.                             :...|...:||:.|||.|.
Human   154 LEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFT 218

  Fly   194 VFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDIS 256
            .|: .:..|.||..|.||||:.|:|.||  .|:|.|.|:...:..|.|..:|.|||:||.|:||.
Human   219 AFL-PDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQ 282

  Fly   257 VRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALP 321
            :||:||:....|||.||||..||||:|.||.||||:|..::||:||.||:||||.||..|||..|
Human   283 IRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKP 347

  Fly   322 FEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQP---------------------- 364
            |.|.|....|       ..::||              ::::.|
Human   348 FLYYPEIKDK-------EEVQRK--------------RQKLMPNFSDSFGGGSGAGAGGGGMFGS 391

  Fly   365 ---------------------PTIEVIDL--DTPKIDVQREIPSEMEFNH----EESQQSEPALE 402
                                 ||...|..  .|.|        |.....|    .||::.....:
Human   392 GGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTK--------SNAGMKHGTMDTESKKDPEGCD 448

  Fly   403 QE-------------QSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQ 454
            :.             ::.:|:|...|.::...:.|...:...::  :....|.:..||:.||..:
Human   449 KSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKE--ESAGVQDNLFLEKAMQLAK 511

  Fly   455 ELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTII--------DEKV 511
            . .|...||.|:      |.|  .:.:.|...|       |.:.|::..|:::        .:.|
Human   512 R-HANALFDYAV------TGD--VKMLLAVQRH-------LTAVQDENGDSVLHLAIIHLHSQLV 560

  Fly   512 RELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELL 576
            |:|.::..|       |.::|.|.  |::...:..:|....|.:.||::..|........||.|.
Human   561 RDLLEVTSG-------LISDDIIN--MRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLG 616

  Fly   577 ETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAPLQVEDSFDDAATYTSLQIAFKNPVLIPMD 641
            .:|..|.......||.....|:.          :|.|.::....|..          |.:.:.|.
Human   617 NSVLHLAAKEGHDKVLSILLKHK----------KAALLLDHPNGDGL----------NAIHLAMM 661

  Fly   642 DIMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPK 706
            ....|...:...|..|         ||:|.:|            .....:....|.|.: .|...
Human   662 SNSLPCLLLLVAAGAD---------VNAQEQK------------SGRTALHLAVEHDNI-SLAGC 704

  Fly   707 RIRKQDSNAENRSIEANT-VQTKPSTGESPLNKRLPPAPKNP---NFNTL------------PRQ 755
            .:.:.|::.::.:.:..| :......|.:.|...|..|..:|   ||..|            ...
Human   705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769

  Fly   756 KKPGFFSKLFSRRKSKP-DLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSK-SAAPFI 818
            ..||          :.| |:|...:...||:.|....|.:......|..|:......| .....:
Human   770 VVPG----------TTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLL 824

  Fly   819 SNPAPAKSSPVKAKKPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLKGDSVNSLPQQQRTEGY 883
            ..|.|.|:....|:|.|..:       :::.....||.....:.:..:.|.:|..|.:..|..||
Human   825 EIPDPDKNWATLAQKLGLGI-------LNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGY 882

  Fly   884 SQSSTISVGAGLDRRTASALQLADIPISEGG--MELVAIADRQSLHNLVSSIEGHFNVQLDPNLD 946
            :::..:...|....:|.|  |...:|:|...  .::..:.|..|:.:  |.:|..|.     .|.
Human   883 TEAIEVIQAASSPVKTTS--QAHSLPLSPASTRQQIDELRDSDSVCD--SGVETSFR-----KLS 938

  Fly   947 LTEA 950
            .||:
Human   939 FTES 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	71/202 (35%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	55/100 (55%)
NFKB1	NP_001369554.1	ANK repeat	685..717	CDD:293786	4/32 (13%)
		Ank_2	690..>733	CDD:423045	6/43 (14%)
		Death_NFkB1_p105	816..891	CDD:260063	15/81 (19%)
		RHD-n_NFkB1	43..244	CDD:143651	71/202 (35%)
		IPT_NFkappaB	251..352	CDD:238582	55/100 (55%)
		Nuclear localization signal. /evidence=ECO:0000255	361..366		2/18 (11%)
		GRR	373..395		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..454		5/35 (14%)
		Interaction with CFLAR. /evidence=ECO:0000269\|PubMed:13679070	436..969		108/602 (18%)
		ANKYR	500..706	CDD:223738	51/272 (19%)
		ANK repeat	543..580	CDD:293786	9/45 (20%)
		ANK repeat	582..613	CDD:293786	5/30 (17%)
		Ank_2	587..681	CDD:403870	23/122 (19%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000269\|PubMed:17003112	651..685		10/64 (16%)
		ANK repeat	651..681	CDD:293786	8/48 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157540
Domainoid	1	1.000	116	1.000	Domainoid score	I5955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5599
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900