Protein Alignment dl and nfkb2

DIOPT Version :10

• Sequence 1: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001005032.1
• Gene: nfkb2 / 448550
• XenbaseID: XB-GENE-970084
• Length: 946
• Species: Xenopus tropicalis
• Alignment Length: 1021
• Identity: 243/1021 - (23%)
• Similarity: 387/1021 - (37%)
• Gaps: 277/1021 - (27%)

  Fly    36 LAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVV 100
            |.|...||   .::.|.|||..:..||||.|||.|.|.:||.:|....|||||::|..|.|.|.:
 Frog    35 LGQDMANV---AFLSIIEQPKQRGFRFRYVCEGPSHGGLPGASSEKGKKTYPTVKIFNYVGMARI 96

  Fly   101 VVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAR--- 162
            .|..||...|.|.|.|:||||...:.|.|.:.:..|.|.|.|:||||..|.||.....||.:
 Frog    97 EVDLVTHIDPPRVHAHSLVGKHSNETGNCVVTVGPEDMTAQFNNLGIVHVTKKSQTEILKEKMKR 161

  Fly   163 --------------EEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVS 213
                          ||.|::.     ..:......||:.|||.|..:: .:..|.:|..||||:|
 Frog   162 QILRHTGRNLLTEAEERRIEQ-----EVKELKKVTDLSIVRLRFTAYL-PDSNGAYTLGLPPVIS 220

  Fly   214 EPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFE-EKNGQSVWEAFGDF 275
            :||.|.|:  .|:|.|.|:...:.:|.|..::.|||:||.|:||.|||:| ::||   |::||||
 Frog   221 DPIHDSKSPGASNLRISRMDKTAGSVKGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQSFGDF 282

  Fly   276 QHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRH 340
            ..||||||.||.|:||.|||..|..|..||:||:|...|..|::..|.|.|::..|.
 Frog   283 APTDVHKQYAIVFRTPPYHTQKIDRPVTVFLQLKRKKGGDVSDSKQFTYYPLEQDKE-------- 339

  Fly   341 LKRKPDEDLFQQILRLDAKREVQPPTI--------------------------EVIDLDTPKIDV 379
                          .:|.||....||.                          ..|:...|.:..
 Frog   340 --------------EVDRKRRKDLPTFNNHFFGGGSPMGGAGGGSSFGQGGGGSNINYPYPGMQT 390

  Fly   380 QREIPSEMEFNHEES----------QQSEPALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQY 434
            ...:.|.....:..|          ..||.  .|..|:..::..:|.|...:| .:..|.|:|..
 Frog   391 AFYMSSPAGGGYHSSGHMMKHCSAANSSEK--NQAPSINIKKEGEEASACSQQ-ARSTSAQKETQ 452

  Fly   435 LQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQ 499
            .|.:..|.:......:...|. .::...|.||      |:|  |..:.|...|       |.:.|
 Frog   453 CQMIMHQANLCNMRMLSLTQR-TSRALLDYAI------TAD--PRMLLAVQRH-------LIATQ 501

  Fly   500 EKEIDT------------IIDEKVREL------EQLDLGQQLEPRPL-----TANDKITEWMKSS 541
            ::..||            :|::.|:.:      :.|::...|:..||     |....:..::..:
 Frog   502 DENGDTPLHLAVIHGQPSVIEQLVQVIISIPNQQILNMSNHLQQTPLHLGVITKQYSVVAFLLKA 566

  Fly   542 EIEQQVHEPSPTAEADVLD----SALEI---SKADKTLDELLE--TVAELD-----------EIY 586
                       .|:..:||    |.|.:   ::.||.|..||:  :|.:.|           .::
 Frog   567 -----------GADPTILDRYGNSVLHLAVQAEDDKMLSVLLKYPSVGQKDLLNMPDYHGLCPVH 620

  Fly   587 TDFKVQRDTYKNTIQNELAGL------QGRAPLQVEDSFD----------------DAATY---T 626
            ...|::.:.....:....|.:      .|::||.:....|                :|.||   |
 Frog   621 WSVKMKNEKCLELLVKAGANVNSPERKSGKSPLHIAVEMDNLNMAIFLVKKSHADINAKTYGGNT 685

  Fly   627 SLQIAFK--NPVLIPMDDIMPPTPPMSQCAPEDAH---QHYDPV----EVNSQARKPETPMRPVP 682
            .|.:|..  :|:|..|            ...|.|:   ::.:||    ..||...:.::
 Frog   686 PLHLAASRGSPMLTKM------------LVNEGANVLSENDEPVNKLPSCNSDTSESDS------ 732

  Fly   683 PVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLP-----P 742
                   .:|...:.|.............||:.|:.:.|.::.:.:.......:.:|.|     .
 Frog   733 -------DVQMDTDSDHHGGSDTDSSTAVDSDCEHSAEEMHSKEQRGIRPHCAVKRRYPGHTALD 790

  Fly   743 APKNPNFNTLPRQKKPGFFSKLFSRRKSKPD----------------LAQGQENSSILDSKANSR 791
            ..|:.....:..:..||  |..:.||:.:|.                |.:||..:...:..:..|
 Frog   791 LTKSQKVRDILSKHTPG--SASWKRREPEPVNVLALETNTVQRLEKLLNEGQTGADWTELASRLR 853

  Fly   792 EPSI--GHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAKKPGSKLTKPVGRSVSSVSGKRP 854
            ..|:  .:.|...|..:.|||.:.|                    |..||:.: .::.|:.
 Frog   854 LQSLVETYRNTSSPTESLLRSYELA--------------------GGSLTELI-NTLQSMG---- 893

  Fly   855 AYLNADVVHIPLKGDSVNSLPQQQRTEGYSQSSTISVGAGLDRRTA 900
              ||..|   .|...|......|...||.:.|:..|....:|:.:|
 Frog   894 --LNKGV---ELLCKSETYAKHQSPAEGKNDSAYESQSMEVDQSSA 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	70/189 (37%)
		IPT_NFkappaB	225..326	CDD:238582	49/101 (49%)
nfkb2	NP_001005032.1	RHD-n_NFkB2	44..227	CDD:143650	70/188 (37%)
		IPT_NFkappaB	234..333	CDD:238582	49/101 (49%)
		ANKYR	489..721	CDD:440430	44/261 (17%)
		ANK repeat	504..541	CDD:293786	5/36 (14%)
		ANK repeat	543..574	CDD:293786	5/41 (12%)
		ANK repeat	614..645	CDD:293786	2/30 (7%)
		ANK repeat	648..680	CDD:293786	5/31 (16%)
		ANK repeat	682..707	CDD:293786	7/36 (19%)
		Death_NFkB2_p100	828..903	CDD:176776	19/104 (18%)