DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dl and nfkb2

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_001001840.2	Gene:	nfkb2 / 415100	ZFINID:	ZDB-GENE-030131-6701	Length:	902	Species:	Danio rerio

Alignment Length:	346	Identity:	132/346 - (38%)
Similarity:	187/346 - (54%)	Gaps:	36/346 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YNGLPAQ------QQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPEN 83
            |:.||..      :.:...|.|.:   .||::|.|:|..:..||||||||.|.|.:||.:|....
Zfish    28 YDDLPYMPEAFEVKHEPFVQETVD---GPYIQIIEEPKQRGFRFRYECEGPSHGGLPGASSERNR 89

  Fly    84 KTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQ 148
            :||||::::.:.|.|.|.|..||...|.|.|.|:|||:...:.|||::::......|.||||||.
Zfish    90 RTYPTVKVLNFVGNARVEVQLVTHTDPPRVHAHSLVGRHCNESGVCSVDVGPSDFTAQFSNLGIL 154

  Fly   149 CVKKKDIEAAL--KAREEIRVDPFKTGFSHRFQPS--------------SIDLNSVRLCFQVFME 197
            .|.|:.:...|  :.:||.|.   ..|..::|..:              ::|||.|||.|..:::
Zfish   155 HVTKRGVVEVLTKRLKEEKRK---VKGPGYKFSDAEENALMQEAKELGKNMDLNIVRLKFTAYLQ 216

  Fly   198 SEQKGRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFF 260
             :..|.:|..|.||||.||:|.|:  .|:|.|.|:...|.:|.|..::.|||:||.|:||.:||:
Zfish   217 -DSNGSYTRALKPVVSNPIYDSKSPNASNLKISRMDKTSGSVLGGEEVFLLCDKVQKDDIDIRFY 280

  Fly   261 EEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYV 325
            ||   :..|||.|||..||||||.||.||||.|...:|..|..||:||:|...|..||...|.||
Zfish   281 EE---EDEWEALGDFSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSEPKQFTYV 342

  Fly   326 PMDSGKHTFWNLHRHLKRKPD 346
            |.:..|...  ..:.:|..||
Zfish   343 PHNQDKEEV--QRKRMKALPD 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	70/188 (37%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	49/100 (49%)
nfkb2	NP_001001840.2	RHD-n_NFkB2	53..238	CDD:143650	70/188 (37%)
		RHD_dimer	246..344	CDD:292797	49/100 (49%)
		Ank_2	<483..558	CDD:289560
		ANK	485..619	CDD:238125
		ANK repeat	488..525	CDD:293786
		ANK repeat	528..558	CDD:293786
		Ank_2	532..627	CDD:289560
		ANK	558..687	CDD:238125
		ANK repeat	560..596	CDD:293786
		ANK repeat	599..629	CDD:293786
		Ank_2	604..697	CDD:289560
		ANK repeat	632..664	CDD:293786
		ANK repeat	666..697	CDD:293786
		Death_NFkB2_p100	794..867	CDD:176776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020