DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and rela

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_005170853.1	Gene:	rela / 415099	ZFINID:	ZDB-GENE-040825-4	Length:	588	Species:	Danio rerio

Alignment Length:	601	Identity:	193/601 - (32%)
Similarity:	278/601 - (46%)	Gaps:	109/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            |:|:|.|||..:.:||||:|||||||||||..|....||:|.|.:..|.|...|.:|.|||:.||
Zfish    18 PHVEIIEQPKSRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIRVHNYSGPVRVRISLVTKNQPY 82

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSH 176
            :||||.||||: ||.|....::....:.: |.|||||||||||:..|:..|.:.:.:|||.. ..
Zfish    83 KPHPHELVGKD-CKHGYYEADLQERRIHS-FQNLGIQCVKKKDVGEAVSCRLQTQNNPFKIP-DA 144

  Fly   177 RFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVICRLCSCSATVFG 239
            :......|||:|||||||.:.......|  ||.||||:||:|.:|  .::|.|||:...|.:..|
Zfish   145 KIWEEEFDLNAVRLCFQVSITLSSGDLF--PLEPVVSQPIYDNRAPNTAELKICRVNRNSGSCRG 207

  Fly   240 NTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKV 304
            ..:|.|||:||.||||.||||.:.     ||:.|.|...|||:|.||.|:||.|...::|||.:|
Zfish   208 GDEIFLLCDKVQKEDIEVRFFLDS-----WESKGSFSQADVHRQVAIVFRTPPYCDTNLTEPLRV 267

  Fly   305 FIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLD------------ 357
            .:|||||||...||.:.|:|:|.|..:|....     |||..|.:... |:|.
Zfish   268 KMQLRRPSDREVSEPMDFQYLPSDPDEHRLME-----KRKRTEGMLHN-LKLSSIITGSSMSAER 326

  Fly   358 -----AKREV----------QPPTIEVID----LDTPKIDVQREIPSEMEFNHEESQQSEPALEQ 403
                 |||.:          .|.::..:.    |..|........|.:: |.   .|:.||:...
Zfish   327 RPFPTAKRTLPVSKQPVAASAPASVPAVSAAPPLKPPPTSFFSPPPGQL-FT---QQKMEPSPLP 387

  Fly   404 EQSVQQEQYTQEQSLQQEQ--------------------YTQEQSLQQEQYLQQLEQQQSFQLE- 447
            ..|....:|.|..|:..:.                    .||.........|.....:.|...|
Zfish   388 ASSSDIWKYLQAMSVDSQPKAVPVLPFPSGTVSTALPTCLTQAFPTVNLSDLHDCTIKSSTIAEP 452

  Fly   448 EPMQQDQELP-AQQSFDQAIDH-LPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIIDEK 510
            .|::..:..| .|.:|...::: .||   :::|:....::.....:     |...::|..|:|:.
Zfish   453 APLKDPEPAPEVQSAFTIRMNNTFPD---ENLPDFPSFSELQGSGD-----SISNEDIQAILDQS 509

  Fly   511 VRELEQLDLGQQLEPRPL----TANDKITEWMKSSEIEQQVHEPSPTAEADVL---DSALEISKA 568
            .|        |:| |.|.    :|.|  ..||       ..|...|....:|.   :.|.|.:.|
Zfish   510 TR--------QKL-PEPCCELPSAAD--LSWM-------GYHPNFPGLHGNVTAQDNGAGEAAAA 556

  Fly   569 DKTLDELLETVAELDE 584
            ...||:|:|..:..|:
Zfish   557 PSVLDDLVELTSMEDD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	83/172 (48%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	49/100 (49%)
rela	XP_005170853.1	RHD-n_RelA	18..186	CDD:143645	83/172 (48%)
rela	XP_005170853.1	IPT_NFkappaB	193..289	CDD:238582	49/100 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593304
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm6520
orthoMCL	1	0.900	-	-		OOG6_105422
Panther	1	1.100	-	-	LDO	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850