Protein Alignment dl and Dif

DIOPT Version :9

• Sequence 1: NP_001286014.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Alignment Length: 1081
• Identity: 415/1081 - (38%)
• Similarity: 558/1081 - (51%)
• Gaps: 202/1081 - (18%)

  Fly     7 NGAAPGQGP---AVDG--------QQSLNYNGLPAQ-----QQQQLAQS--TKNVRKKPYVKITE 53
            ||.|.|.|.   ||.|        .||.:...:|:.     |.|.:.|:  ..:.|..|:::|.|
  Fly    20 NGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVE 84

  Fly    54 QPAGKALRFRYECEGRSAGSIPGVNSTPE-NKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHN 117
            :|....:||||:||||:||||||:||:.| .||:||||:..|.|..::||||||.|.|:|.|||.
  Fly    85 EPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHW 149

  Fly   118 LVGKE---GCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQ 179
            ||.||   .||.|:...::..|..|.|...:||||.||.::..:|..||...:|||...|.|:.|
  Fly   150 LVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQ 214

  Fly   180 PSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGNTQII 244
            ...|:...:|||:|.|:   ..|....||.|:||.||:.|.  |:|.|.|||||:||..|..:||
  Fly   215 IDKINRYELRLCYQAFI---TVGNSKVPLDPIVSSPIYGKS--SELTITRLCSCAATANGGDEII 274

  Fly   245 LLCEKVAKEDISVRFFE-EKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQL 308
            :||||:||:||.|||:| :|:|:..|.|..:||.|||.||.||.||||||...:||:...|.::|
  Fly   275 MLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKL 339

  Fly   309 RRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLD 373
            .|||||.||..|||||.| :.|..||..|.|.|||:.:.|:|||||.||::......:...:||:
  Fly   340 VRPSDGATSAPLPFEYYP-NPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCPPMDLE 403

  Fly   374 TPKIDVQREIPSEMEFNHEESQQSEPAL-EQEQSVQQEQYTQE-QSLQQE-----QYTQEQSLQQ 431
            .....|.           .:.|||...| |.|.:|::.|..|. :|.:.:     :||...:
  Fly   404 EDNNTVS-----------SDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDN--- 454

  Fly   432 EQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLR 496
                   |.....:||.|    |.||      |..|   |.|....|
  Fly   455 -------EPDMEIELEVP----QLLP------QLAD---DCTQTSTP------------------ 481

  Fly   497 SEQEKEIDTIIDEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDS 561
                             :|::....||:.|||:..:.|||||||||.|:   ..|.|.|.....|
  Fly   482 -----------------MEEILQHPQLQSRPLSNVETITEWMKSSEFER---TDSLTVENGDTQS 526

  Fly   562 ALEISKADKTLDELLETVA------ELDEIYTDFKV---QRDTYKNTI---------QNELAGLQ 608
             |..|.|......:....|      :|||.......   :|||.:|..         :.|:....
  Fly   527 -LSNSTAQTAFTNVSSLTANTTITNQLDEEAHGLLANGSRRDTLENPAVKELPENEKEPEMVSAS 590

  Fly   609 GRAPLQVEDSFDDAATYTSLQIAFKNPVLI--PMDD-----IMPPTPPMSQCAPEDAHQHYDP-- 664
            .:|.:.::::||:.||||||||||.||:.|  |.:.     |.|||.|..|...::.....:|
  Fly   591 AQASMDLDENFDETATYTSLQIAFNNPIDIGLPKESKQAAPIYPPTNPFGQLDDDELVVLTNPPA 655

  Fly   665 --VEVN---SQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANT 724
              ::||   :.|..|.:|..|:||..|:      |..:.:|||||||..|    |:::.|..:::
  Fly   656 PRIKVNAAQTPATPPASPPLPLPPRTPS------PVSDQRLPPLPPKPQR----NSQDLSAVSDS 710

  Fly   725 VQTKPSTGESPLNKRLPPAP----KNPNFNTLPRQ--------KKPGFFSKLFSRRKSKPDLAQ- 776
            :....|...|..:.|..|:|    :.|:.:...||        |:.||||:.||||:||.|..:
  Fly   711 ISVSRSRNGSLSSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQGFFSRFFSRRRSKTDDEES 775

  Fly   777 ----GQENSSIL-DSKA----NSREPSIGHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAK 832
                |..|..:. .|||    .|||||:.||::.||.|:|.||.:...
  Fly   776 LTPGGSPNKQLPGGSKATTPTGSREPSVAHFSLGDPNRSSTRSMQPLG----------------- 823

  Fly   833 KPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLK-GDSVNSLPQQQRTEGYSQSSTISVGAGLD 896
            |...:..||||||.|||||||||:|:|||:||||| |||.|||   .|.|.||.:||:|.|..||
  Fly   824 KSEGRNGKPVGRSSSSVSGKRPAHLDADVIHIPLKGGDSENSL---LRPESYSNASTLSYGRPLD 885

  Fly   897 RRTASALQLADIPISEGGMELVAIADRQSLHNLVSSIEGHFNVQLDPNLDLTEAEHFALYTS--- 958
            |:|.|.|||||||||:|.|||:|||||||:.||   .||.:.|.|||::||:||||||||||
  Fly   886 RKTLSTLQLADIPISDGNMELIAIADRQSIKNL---CEGAYGVVLDPSVDLSEAEHFALYTSKSP 947

  Fly   959 IPPLAAASEFDETSAYYAPVDAGEILTPDEVAKRLAAANGI 999
            .||.  ..|..|..|....||..:.|:.||:|:|||.|||:
  Fly   948 EPPF--GGECGEGGAATGGVDTTDFLSADEIARRLAEANGL 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	80/176 (45%)
		IPT_NFkappaB	225..326	CDD:238582	59/101 (58%)
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	80/176 (45%)
		RHD_dimer	256..358	CDD:292797	59/102 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469446
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	1	0.900	-	-		E1_2CMKZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17146at6656
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm6520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.880