Protein Alignment dl and Nfkb2

DIOPT Version :10

• Sequence 1: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_001008350.1
• Gene: Nfkb2 / 309452
• RGDID: 1307189
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 838
• Identity: 212/838 - (25%)
• Similarity: 324/838 - (38%)
• Gaps: 241/838 - (28%)

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            ||:.|.|||..:..||||.|||.|.|.:||.:|....|||||::|..|:|.|.:.|..||...|.
  Rat    38 PYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPP 102

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKD-IEAALK--AREEIRVDPFKTG 173
            |.|.|:||||:..:.|||.:.:..:.|.|.|:|||:..|.||: :|..::  .|:.:|..|....
  Rat   103 RAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQGLT 167

  Fly   174 FSHRFQ--------PSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVIC 228
            .:.|.:        ...:||:.|||.|..|:.:.. |.|:.||.||:|:||.|.|:  .|:|.|.
  Rat   168 EAERRELEQEAKELKKVMDLSIVRLRFSAFLRASD-GSFSLPLKPVISQPIHDSKSPGASNLKIS 231

  Fly   229 RLCSCSATVFGNTQIILLCEKVAKEDISVRFFE-EKNGQSVWEAFGDFQHTDVHKQTAITFKTPR 292
            |:...:.:|.|..::.|||:||.|:||.|||:| ::||   |:|||||..||||||.||.|:||.
  Rat   232 RMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQAFGDFSPTDVHKQYAIVFRTPP 293

  Fly   293 YHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQ----- 352
            ||.:.|..|..||:||:|...|..|::..|.|.|:...|.   .:.|  ||:.....|.|
  Rat   294 YHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKE---EVQR--KRRKALPTFSQPFGGG 353

  Fly   353 ---------------------ILRLDAKREVQPPTIEVIDLDTPKIDVQREIP-----SEMEFNH 391
                                 .|...:.....|.......:..        .|     ::|..:.
  Rat   354 SHMGGGSGGSAGGYGGAGGGGSLGFFSSFAYSPYQSGAAPMGC--------FPGGGGGAQMAGSG 410

  Fly   392 EESQQSEPALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQEL 456
            .:::..| |.||.::..:...:::|:|...|..:|       |..:|     |.|
  Rat   411 RDAEAGE-AEEQPRAPSEAPQSEQQALDTLQRARE-------YNARL-----FGL---------- 452

  Fly   457 PAQQSFDQAIDHLPDHTSDHIPEDMEAADAHA--EAEAHRLRSEQEKEIDT-----IIDEKVREL 514
             ||:|....:|:            ...|||.|  ..:.|.|.::.|.. ||     ||..:...:
  Rat   453 -AQRSARALLDY------------GVTADARALLAGQRHLLMAQDENG-DTPLHLAIIHGQTGVI 503

  Fly   515 EQ-------------LDLGQQLEPRPL-----TANDKITEWMKSSEIEQQV---HEPSP------ 552
            ||             ::|...|...||     |...::..::.....:..:   |..|.
  Rat   504 EQIAQVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSAVHLALR 568

  Fly   553 --TAEADVLDSALEI-------------------------SKADKTLDELLETVAELDEIYTDFK 590
              .|..|:|.:.|..                         :::.:.||.|::..||::..
  Rat   569 AGAAAPDLLQAVLHSGAHALPQMLHMPDFEGLYPVHLAVHARSPECLDLLVDCGAEVEAA----- 628

  Fly   591 VQRDTYKNTIQNELAGLQGRAPLQVEDSFDDAATYTSLQIAFKNPVLIPMDDIMPPTPPMSQCAP 655
                        |..|  ||.||.:....::....|.|.....
  Rat   629 ------------ERQG--GRTPLHLATEMEELGLVTHLVTKLH---------------------- 657

  Fly   656 EDAHQHYDPVEVNSQARKPETPMRPVPPVPPAILTIQ--------YPPEEDKLPPLPPKRIRKQD 712
                     ..||::.....||:.....:....||..        :...|:.|.|||.......|
  Rat   658 ---------ANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLPSPPTSGSD 713

  Fly   713 SNAE------------------NRSIEANT--VQTKPSTGESPLNKRLPPAPKNPNFN 750
            |::|                  .||.:..|  :....:|.|.||   .||:|..|..:
  Rat   714 SDSEGPETDTQRNFRGHTPLDLTRSTKVKTLLLNAAQNTTEPPL---APPSPAGPGLS 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	72/183 (39%)
		IPT_NFkappaB	225..326	CDD:238582	49/101 (49%)
Nfkb2	NP_001008350.1	RHD-n_NFkB2	38..221	CDD:143650	72/183 (39%)
		IPT_NFkappaB	228..327	CDD:238582	49/101 (49%)
		ANKYR	435..705	CDD:440430	57/355 (16%)
		ANK repeat	486..523	CDD:293786	7/37 (19%)
		ANK repeat	525..556	CDD:293786	4/30 (13%)
		ANK repeat	558..585	CDD:293786	6/26 (23%)
		ANK repeat	598..629	CDD:293786	5/47 (11%)
		ANK repeat	632..664	CDD:293786	9/64 (14%)
		ANK repeat	666..697	CDD:293786	4/30 (13%)
		Death_NFkB2_p100	773..847	CDD:176776