Protein Alignment dl and Rela

DIOPT Version :10

• Sequence 1: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Sequence 2: NP_954888.1
• Gene: Rela / 309165
• RGDID: 727889
• Length: 550
• Species: Rattus norvegicus
• Alignment Length: 581
• Identity: 191/581 - (32%)
• Similarity: 267/581 - (45%)
• Gaps: 103/581 - (17%)

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            |||:|.|||..:.:||||:|||||||||||..||...||:|||:|.||.|...|.:|.||||.|:
  Rat    19 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPH 83

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSH 176
            |||||.||||: |:.|....|:..:.....|.|||||||||:|:|.|:..|.:...:||:.....
  Rat    84 RPHPHELVGKD-CRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEE 147

  Fly   177 RFQPSSIDLNSVRLCFQVFMESEQKGRFTSP--LPPVVSEPIFDKKA--MSDLVICRLCSCSATV 237
              |....|||:|||||||.:. :..||   |  |.||:|.||||.:|  .::|.|||:...|.:.
  Rat   148 --QRGDYDLNAVRLCFQVTVR-DPSGR---PLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSC 206

  Fly   238 FGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPA 302
            .|..:|.|||:||.||||.|.|    .|.. |||.|.|...|||:|.||.|:||.|....:..|.
  Rat   207 LGGDEIFLLCDKVQKEDIEVYF----TGPG-WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPV 266

  Fly   303 KVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILR---LDAKREVQP 364
            :|.:|||||||...||.:.|:|:|....:|..     ..|||...:.|:.|::   .:...|.:|
  Rat   267 RVSMQLRRPSDRELSEPMEFQYLPDTDDRHRI-----EEKRKRTYETFKSIMKKSPFNGPTEPRP 326

  Fly   365 PTIEVIDLDTPKIDVQREIPSEMEF-------NHEE--------SQQSEPALEQEQSVQQEQYTQ 414
            |...:.........|.:..|....|       |.:|        .|.|..||....|
  Rat   327 PPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPS-------- 383

  Fly   415 EQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPE 479
                            ....|.|.....|..:....|....:|.      .....|...|..:|:
  Rat   384 ----------------SAPVLAQTMVPSSAMVPSLAQPPAPVPV------LAPGPPQSLSAPVPK 426

  Fly   480 DMEAADAH-AEAEAHRLRSEQEKEIDTIIDEKV-------------RELEQLDLGQQL------- 523
            ..:|.:.. :||..| |:.:.::::..::....             .|.:|| |.|.:
  Rat   427 STQAGEGTLSEALLH-LQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQL-LNQGVAMSHSTA 489

  Fly   524 EPRPLTANDKITEWMKSSEIEQQVHEPSP-TAEADVLDSALEISKADKTLDELLETVAELD 583
            ||..:...:.||..:..|   |:..:|:| |.....|.:.|       :.||...::|::|
  Rat   490 EPMLMEYPEAITRLVTGS---QRPPDPAPATLGTSGLPNGL-------SGDEDFSSIADMD 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	90/174 (52%)
		IPT_NFkappaB	225..326	CDD:238582	47/100 (47%)
Rela	NP_954888.1	RHD-n_RelA	19..187	CDD:143645	90/174 (52%)
		IPT_NFkappaB	194..290	CDD:238582	47/100 (47%)
		Nuclear localization signal. /evidence=ECO:0000255	301..304		2/2 (100%)
		Transcriptional activation domain 3. /evidence=ECO:0000250|UniProtKB:Q04207	342..388		9/69 (13%)
		Transcriptional activation domain 1. /evidence=ECO:0000250|UniProtKB:Q04206	414..476		9/62 (15%)
		Transcriptional activation domain 2. /evidence=ECO:0000250|UniProtKB:Q04207	520..550		6/28 (21%)
		9aaTAD. /evidence=ECO:0000255	535..543		2/6 (33%)