DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and Rela

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_954888.1	Gene:	Rela / 309165	RGDID:	727889	Length:	550	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	191/581 - (32%)
Similarity:	267/581 - (45%)	Gaps:	103/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            |||:|.|||..:.:||||:|||||||||||..||...||:|||:|.||.|...|.:|.||||.|:
  Rat    19 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPH 83

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSH 176
            |||||.||||: |:.|....|:..:.....|.|||||||||:|:|.|:..|.:...:||:.....
  Rat    84 RPHPHELVGKD-CRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEE 147

  Fly   177 RFQPSSIDLNSVRLCFQVFMESEQKGRFTSP--LPPVVSEPIFDKKA--MSDLVICRLCSCSATV 237
              |....|||:|||||||.:. :..||   |  |.||:|.||||.:|  .::|.|||:...|.:.
  Rat   148 --QRGDYDLNAVRLCFQVTVR-DPSGR---PLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSC 206

  Fly   238 FGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPA 302
            .|..:|.|||:||.||||.|.|    .|.. |||.|.|...|||:|.||.|:||.|....:..|.
  Rat   207 LGGDEIFLLCDKVQKEDIEVYF----TGPG-WEARGSFSQADVHRQVAIVFRTPPYADPSLQAPV 266

  Fly   303 KVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILR---LDAKREVQP 364
            :|.:|||||||...||.:.|:|:|....:|..     ..|||...:.|:.|::   .:...|.:|
  Rat   267 RVSMQLRRPSDRELSEPMEFQYLPDTDDRHRI-----EEKRKRTYETFKSIMKKSPFNGPTEPRP 326

  Fly   365 PTIEVIDLDTPKIDVQREIPSEMEF-------NHEE--------SQQSEPALEQEQSVQQEQYTQ 414
            |...:.........|.:..|....|       |.:|        .|.|..||....|
  Rat   327 PPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPS-------- 383

  Fly   415 EQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPE 479
                            ....|.|.....|..:....|....:|.      .....|...|..:|:
  Rat   384 ----------------SAPVLAQTMVPSSAMVPSLAQPPAPVPV------LAPGPPQSLSAPVPK 426

  Fly   480 DMEAADAH-AEAEAHRLRSEQEKEIDTIIDEKV-------------RELEQLDLGQQL------- 523
            ..:|.:.. :||..| |:.:.::::..::....             .|.:|| |.|.:
  Rat   427 STQAGEGTLSEALLH-LQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQL-LNQGVAMSHSTA 489

  Fly   524 EPRPLTANDKITEWMKSSEIEQQVHEPSP-TAEADVLDSALEISKADKTLDELLETVAELD 583
            ||..:...:.||..:..|   |:..:|:| |.....|.:.|       :.||...::|::|
  Rat   490 EPMLMEYPEAITRLVTGS---QRPPDPAPATLGTSGLPNGL-------SGDEDFSSIADMD 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	90/174 (52%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	47/100 (47%)
Rela	NP_954888.1	RHD-n_RelA	19..187	CDD:143645	90/174 (52%)
Rela	NP_954888.1	IPT_NFkappaB	194..290	CDD:238582	47/100 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351522
Domainoid	1	1.000	173	1.000	Domainoid score	I3594
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm9057
orthoMCL	1	0.900	-	-		OOG6_105422
Panther	1	1.100	-	-	LDO	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2257
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.810