DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and Rel

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_033070.2	Gene:	Rel / 19696	MGIID:	97897	Length:	588	Species:	Mus musculus

Alignment Length:	675	Identity:	204/675 - (30%)
Similarity:	293/675 - (43%)	Gaps:	167/675 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVV 100
            :|.|..|    |||:|.|||..:.:||||:|||||||||||..||..|:|||:::|:.|.|:..:
Mouse     1 MASSGYN----PYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSVQIMNYYGKGKI 61

  Fly   101 VVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEI 165
            .::.|||:.||:||||:||||: |:.|....|...|.....|.||||:|||||:::.|:..|...
Mouse    62 RITLVTKNDPYKPHPHDLVGKD-CRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISA 125

  Fly   166 RVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVIC 228
            .::||.............|||.||||||||:..|. |.||:.|||:||.||:|.:|  .::|.||
Mouse   126 GINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEH-GNFTTALPPIVSNPIYDNRAPNTAELRIC 189

  Fly   229 RLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRY 293
            |:.....:|.|..:|.|||:||.|:||.|||.     .:.|||.|.|...|||:|.||.||||.|
Mouse   190 RVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFV-----LNDWEARGVFSQADVHRQVAIVFKTPPY 249

  Fly   294 HTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDA 358
             ...|.||..|.:|||||||...||::.|.|:|.:  |..:.|   ..|::....:||::|: |.
Mouse   250 -CKAILEPVTVKMQLRRPSDQEVSESMDFRYLPDE--KDAYGN---KSKKQKTTLIFQKLLQ-DC 307

  Fly   359 KREVQPPTIEVIDLDTPKIDVQREIP----SEMEFNHEESQQSE-----PALEQEQSV--QQEQY 412
            ....:.|               |..|    .|..|..:||....     |.:.:...|  |.|.|
Mouse   308 GHFTEKP---------------RTAPLGSTGEGRFIKKESNLFSHGTVLPEMPRSSGVPGQAEPY 357

  Fly   413 TQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLP------D 471
                      |:...|:                       ...||.......::.|.|      .
Mouse   358 ----------YSSCGSI-----------------------SSGLPHHPPAIPSVAHQPTSWPPVT 389

  Fly   472 HTSDH----------------------IP-------EDMEAADAHAEAEAHRLRSEQEKEIDTII 507
            |.:.|                      :|       .|:.|:::.........|.|......|
Mouse   390 HPTSHPVSTNTLSTFSAGTLSSNSQGILPFLEGPGVSDLSASNSCLYNPDDLARMETPSMSPT-- 452

  Fly   508 DEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSE--------IE-------------QQVHEPS 551
                 :|..:.....|..|||:.....|:.|..::        :|             :|:|:.|
Mouse   453 -----DLYSISDVNMLSTRPLSVMAPSTDGMGDTDNPRLVSINLENPSCNARLGPRDLRQLHQMS 512

  Fly   552 PTA-EADVLDSALEISKAD-------KTLDE-LLETVAELDEIYTDFKVQRDTYK--NTIQNELA 605
            |.: .|....|::.:|::|       ..:|. |:......|:......||...|.  ||:|:|
Mouse   513 PASLSAGTSSSSVFVSQSDAFDRSNFSCVDNGLMNEPGLSDDANNPTFVQSSHYSSVNTLQSE-- 575

  Fly   606 GLQGRAPLQVEDSFDDAATYTSLQI 630
                    |:.|.|    ||...:|
Mouse   576 --------QLSDPF----TYGFFKI 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	85/172 (49%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	49/100 (49%)
Rel	NP_033070.2	RHD-n_c-Rel	8..179	CDD:143649	85/172 (49%)
		RHD_dimer	187..282	CDD:292797	48/100 (48%)
		Nuclear localization signal. /evidence=ECO:0000255	291..296		1/4 (25%)
		Transcriptional transactivator	403..468		9/71 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847948
Domainoid	1	1.000	166	1.000	Domainoid score	I3870
eggNOG	1	0.900	-	-		E1_2CMKZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm8810
orthoMCL	1	0.900	-	-		OOG6_105422
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710