DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dl and Nfkb2

DIOPT Version :10

Sequence 1:NP_724054.1 Gene:dl / 35047 FlyBaseID:FBgn0260632 Length:999 Species:Drosophila melanogaster
Sequence 2:NP_001170841.1 Gene:Nfkb2 / 18034 MGIID:1099800 Length:900 Species:Mus musculus


Alignment Length:823 Identity:216/823 - (26%)
Similarity:329/823 - (39%) Gaps:210/823 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            ||:.|.|||..:..||||.|||.|.|.:||.:|....|||||::|..|:|.|.:.|..||...|.
Mouse    38 PYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPP 102

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKD-IEAALK--AREEIRVDPFKTG 173
            |.|.|:||||:..:.|||.:.:..:.|.|.|:|||:..|.||: :|..::  .|:.:|..|....
Mouse   103 RAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQGLT 167

  Fly   174 FSHRFQ--------PSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKA--MSDLVIC 228
            .:.|.:        ...:||:.|||.|..|:.:.. |.|:.||.||:|:||.|.|:  .|:|.|.
Mouse   168 EAERRELEQEAKELKKVMDLSIVRLRFSAFLRASD-GSFSLPLKPVISQPIHDSKSPGASNLKIS 231

  Fly   229 RLCSCSATVFGNTQIILLCEKVAKEDISVRFFE-EKNGQSVWEAFGDFQHTDVHKQTAITFKTPR 292
            |:...:.:|.|..::.|||:||.|:||.|||:| ::||   |:|||||..||||||.||.|:||.
Mouse   232 RMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQAFGDFSPTDVHKQYAIVFRTPP 293

  Fly   293 YHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLD 357
            ||.:.|..|..||:||:|...|..|::..|.|.|:...|                   :::.|  
Mouse   294 YHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDK-------------------EEVQR-- 337

  Fly   358 AKREVQPPTIEVIDLDTPKIDVQREIP-------------------------------SEMEFNH 391
             ||....||...              |                               |.:.:|.
Mouse   338 -KRRKALPTFSQ--------------PFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSSLAYNP 387

  Fly   392 EESQQSEPALEQ-----EQSVQQEQYTQEQSLQQEQYTQEQSLQQE-QYLQQLEQQQS-----FQ 445
            .:|..:......     .|.....:.|......:|..|..::.|.| |.|..|::.:.     |.
Mouse   388 YQSGAAPMGCYPGGGGGAQMAGSRRDTDAGEGAEEPRTPPEAPQGEPQALDTLQRAREYNARLFG 452

  Fly   446 LEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHA--EAEAHRLRSEQEKEIDT--- 505
            |           ||:|....:|:            ...|||.|  ..:.|.|.::.|.. ||   
Mouse   453 L-----------AQRSARALLDY------------GVTADARALLAGQRHLLMAQDENG-DTPLH 493

  Fly   506 --IIDEKVRELEQ-------------LDLGQQLEPRPL-----TANDKITEWMKSSEIEQQVHEP 550
              ||..:...:||             ::|...|...||     |...::..::.....:      
Mouse   494 LAIIHGQTGVIEQIAHVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGAD------ 552

  Fly   551 SPTAEADVLDSALEIS-KADKTLDELLETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAPLQ 614
             ||......||||.:: :|.....|||:.:...........:....::......|| :..|:|..
Mouse   553 -PTLLDRHGDSALHLALRAGAAAPELLQALLRSGAHAVPQILHMPDFEGLYPVHLA-VHARSPEC 615

  Fly   615 VEDSFDDAATY---------TSLQIAFKNPVLIPMDDIMPPTPPMSQCAPEDAHQHYDPVEVNSQ 670
            ::...|..|..         |:|.:|.:      |:::...|..:::.       |   ..||::
Mouse   616 LDLLVDCGAEVEAPERQGGRTALHLATE------MEELGLVTHLVTKL-------H---ANVNAR 664

  Fly   671 ARKPETPMRPVPPVPPAILTIQ--------YPPEEDKLPPLPPKRIRKQDSNAE--NRSIEAN-- 723
            .....||:.....:....||..        :...|:.|.|||.......||::|  .|..:.|  
Mouse   665 TFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLPSPSTSGSDSDSEGPERDTQRNFR 729

  Fly   724 -------TVQTK---------PSTGESPLNKRLPPAPKNPNFN 750
                   |..||         .:|.|.||   .||:|..|..:
Mouse   730 GHTPLDLTCSTKVKTLLLNAAQNTTEPPL---APPSPAGPGLS 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dlNP_724054.1 RHD-n_Dorsal_Dif 47..220 CDD:143647 72/183 (39%)
IPT_NFkappaB 225..326 CDD:238582 49/101 (49%)
Nfkb2NP_001170841.1 RHD-n_NFkB2 38..221 CDD:143650 72/183 (39%)
IPT_NFkappaB 228..327 CDD:238582 49/101 (49%)
Nuclear localization signal. /evidence=ECO:0000255 337..341 3/6 (50%)
GRR 346..377 1/44 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..434 5/30 (17%)
ANKYR 453..706 CDD:440430 54/300 (18%)
ANK repeat 487..524 CDD:293786 7/37 (19%)
ANK 1 487..516 6/29 (21%)
ANK repeat 526..557 CDD:293786 6/37 (16%)
ANK 2 526..555 5/35 (14%)
ANK 3 559..590 8/30 (27%)
ANK repeat 559..586 CDD:293786 8/26 (31%)
ANK repeat 599..630 CDD:293786 6/31 (19%)
ANK 4 599..628 6/29 (21%)
ANK repeat 633..665 CDD:293786 8/47 (17%)
ANK 5 633..663 7/45 (16%)
ANK repeat 667..698 CDD:293786 4/30 (13%)
ANK 6 667..696 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..734 10/35 (29%)
ANK 7 729..755 4/25 (16%)
Death_NFkB2_p100 774..849 CDD:176776
Blue background indicates that the domain is not in the aligned region.

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