DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and Nfkb1

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	NP_032715.2	Gene:	Nfkb1 / 18033	MGIID:	97312	Length:	971	Species:	Mus musculus

Alignment Length:	1061	Identity:	257/1061 - (24%)
Similarity:	380/1061 - (35%)	Gaps:	351/1061 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111
            ||::|.|||..:..||||.|||.|.|.:||.:|....|:||.::|..|.|.|.|:|..||.....
Mouse    40 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNI 104

  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAR-EEIRVDPFKTGF- 174
            ..|.|:||||. |:.||||:....:.|...|:||||..|.||.:...|:|| .|..:..:..|.
Mouse   105 HLHAHSLVGKH-CEDGVCTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLL 168

  Fly   175 ----------------------------SHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPV 211
                                        :...|...:||:.|||.|..|: .:..|.||..|.||
Mouse   169 VHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFL-PDSTGSFTRRLEPV 232

  Fly   212 VSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGD 274
            ||:.|:|.||  .|:|.|.|:...:..|.|..:|.|||:||.|:||.:||:||:....|||.|||
Mouse   233 VSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD 297

  Fly   275 FQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHR 339
            |..||||:|.||.||||:|..::||:||.||:||||.||..|||..||.|.|
Mouse   298 FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYP------------- 349

  Fly   340 HLKRKPDEDLFQQILRLDAKREVQ----------------------------------------- 363
                           .:..|.|||
Mouse   350 ---------------EIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPG 399

  Fly   364 ----------PP--------------------TIEVIDLDTPKIDVQREIPSEMEFNHEESQQSE 398
                      ||                    ||.....:.||...:.:....:....:|::...
Mouse   400 PGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEG 464

  Fly   399 PALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQ----LEEPMQQDQELPAQ 459
            |:|..                  ..|:.:.:.....::..||...||    ||:.:|..:. .|.
Mouse   465 PSLPM------------------ACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARR-HAN 510

  Fly   460 QSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIID--------EKVRELEQ 516
            ..||.|:      |.|  .:.:.|...|       |.:.|::..|:::.        :.||:|.:
Mouse   511 ALFDYAV------TGD--VKMLLAVQRH-------LTAVQDENGDSVLHLAIIHLHAQLVRDLLE 560

  Fly   517 LDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELLETVAE 581
            :..|       |.::|.|.  |::...:..:|....|.:.||::..|.:......||....:|..
Mouse   561 VTSG-------LISDDIIN--MRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLH 616

  Fly   582 L------DEIYTDFKVQRDT-----YKN----------TIQNEL--------AGLQ--------G 609
            |      |.|.:.....|..     :.|          .:.|.|        ||.:        |
Mouse   617 LAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSG 681

  Fly   610 RAPLQVEDSFD----------------DAATY---TSLQIAF---------------KNPV---- 636
            |..|.:...:|                |:.||   |.|.||.               .:|:
Mouse   682 RTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENF 746

  Fly   637 --LIPMDD----------IMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAIL 689
              |..:||          ::|.|.|:...|   ..|.:|.:.     .||..|          :.
Mouse   747 EPLYDLDDSWEKAGEDEGVVPGTTPLDMAA---NWQVFDILN-----GKPYEP----------VF 793

  Fly   690 TIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLPPAPKNPNFNTLPR 754
            |     .:|.||....|:: .:|:..:                   |.|.|.....:.|:.||.:
Mouse   794 T-----SDDILPQGDMKQL-TEDTRLQ-------------------LCKLLEIPDPDKNWATLAQ 833

  Fly   755 QKKPGFFSKLF--SRRKSKPDLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSKSAAPF 817
            :...|..:..|  |...|| .|....|.|.....:.......:|:....:.::|:.|:
Mouse   834 KLGLGILNNAFRLSPAPSK-TLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRT------- 890

  Fly   818 ISNPAPAKSSPVKAKK------PGSKLTKPVG--RSVSSV--SGKRPAYLNADVVHIPLKGD--- 869
               ||...||||...:      ..|...:.:.  |...||  ||...::....... .|.||
Mouse   891 ---PATTASSPVTTAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTE-SLTGDSPL 951

  Fly   870 -SVNSLPQQQRTEGYSQSSTI 889
             |:|.:|     .||.|...|
Mouse   952 LSLNKMP-----HGYGQEGPI 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	72/202 (36%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	55/100 (55%)
Nfkb1	NP_032715.2	RHD-n_NFkB1	40..241	CDD:143651	72/202 (36%)
		IPT_NFkappaB	248..349	CDD:238582	55/100 (55%)
		Nuclear localization signal. /evidence=ECO:0000255	358..363		1/4 (25%)
		GRR	370..392		0/21 (0%)
		Interaction with CFLAR. /evidence=ECO:0000250	433..971		119/638 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..470		5/48 (10%)
		ANK repeat	538..575	CDD:293786	9/45 (20%)
		Ank_4	539..598	CDD:290365	13/67 (19%)
		ANK	572..701	CDD:238125	22/130 (17%)
		ANK repeat	577..608	CDD:293786	5/30 (17%)
		Ank_2	582..676	CDD:289560	17/93 (18%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000250	646..680		4/33 (12%)
		ANK repeat	646..677	CDD:293786	4/30 (13%)
		Ank_5	666..722	CDD:290568	11/55 (20%)
		ANK repeat	680..712	CDD:293786	5/31 (16%)
		Death_NFkB1_p105	812..886	CDD:260063	15/93 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847946
Domainoid	1	1.000	115	1.000	Domainoid score	I6003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5599
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.890