DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dl and relb

DIOPT Version :9

Sequence 1:	NP_001286014.1	Gene:	dl / 35047	FlyBaseID:	FBgn0260632	Length:	999	Species:	Drosophila melanogaster
Sequence 2:	XP_002932654.2	Gene:	relb / 100486410	XenbaseID:	XB-GENE-964072	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	394	Identity:	154/394 - (39%)
Similarity:	218/394 - (55%)	Gaps:	47/394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QQQQLAQSTKNVRKKPY--VKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGY 94
            ::|..:.|..:.|:.||  :||||||..:.:||||:|||||||||.|..||..|||.|.||::..
Frog    63 REQCPSTSWASQRESPYPELKITEQPKQRGMRFRYQCEGRSAGSILGTQSTEHNKTLPEIEVINC 127

  Fly    95 KG--RAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVC--TLEINSETMRAVFSNLGIQCVKKKDI 155
            .|  :..|.|..|.||.|:|.|||.||||: |..|:|  ||...::..:..|||||||||:||:|
Frog   128 DGLEKICVTVCLVWKDPPHRVHPHGLVGKD-CHDGICQVTLHPQNDVAKHSFSNLGIQCVRKKEI 191

  Fly   156 EAALKAREEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKK 220
            ::::..|.::.:||:|.| ..|.. ..:|||.||||||.   |.....|...:.||:||||:|||
Frog   192 DSSVNHRLKLNIDPYKAG-KWRLH-EEVDLNVVRLCFQA---SCTGPGFQYEIAPVLSEPIYDKK 251

  Fly   221 A--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQ 283
            :  .|:|.|.|:...|....|..::.:||:||.||||.|.|.|:.     |||..||...|||:|
Frog   252 STNTSELKISRMNRESGRCEGGEEVYILCDKVQKEDILVIFAEDD-----WEARADFSQADVHRQ 311

  Fly   284 TAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDED 348
            .||..|||.||.|.|||||.|.:.|:|.:||:.||.:||.|:|.....:..     |.||
Frog   312 IAIVLKTPPYHDLHITEPAYVSVFLQRITDGIRSEGIPFVYMPRVKDPNCV-----HSKR----- 366

  Fly   349 LFQQILRLD------------AKREVQPPTIEVIDLDTPKIDVQREIPSEMEFNHEESQQSEPAL 401
            .::..|:|.            .||:|:|...:.::...|      ::|.....|..:...:.|.:
Frog   367 TYRDSLQLSDIGDPDPHGIKMKKRKVKPCYADHLNSSYP------DVPLLDSLNCNDGYHTLPLM 425

  Fly   402 EQEQ 405
            :.::
Frog   426 DNDE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dl	NP_001286014.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	86/178 (48%)
dl	NP_001286014.1	IPT_NFkappaB	225..326	CDD:238582	48/100 (48%)
relb	XP_002932654.2	RHD-n_RelB	80..251	CDD:143646	84/176 (48%)
relb	XP_002932654.2	IPT_NFkappaB	258..354	CDD:238582	48/100 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9475
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050