DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dif and RELA

DIOPT Version :10

Sequence 1:NP_001162998.1 Gene:Dif / 35045 FlyBaseID:FBgn0011274 Length:987 Species:Drosophila melanogaster
Sequence 2:NP_001391586.1 Gene:RELA / 5970 HGNCID:9955 Length:562 Species:Homo sapiens


Alignment Length:625 Identity:179/625 - (28%)
Similarity:266/625 - (42%) Gaps:142/625 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVC----------- 124
            ||:..|||::.|:|:|....:|||||||||:|||||| ..|::|.||.|||:|.           
Human    12 EPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPG-ERSTDTTKTHPTIKVWMSGPLYFGQIN 75

  Fly   125 NYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLE 189
            .|.||..:.:|.||.|.|.|.|||.||.|:    |:.|.|:.:|.|:......|.:||||.||.:
Human    76 GYTGPGTVRISLVTKDPPHRPHPHELVGKD----CRDGFYEAELCPDRCIHSFQNLGIQCVKKRD 136

  Fly   190 MRDSLVERERRNIDPFNAKFDHKDQIDKINRYEL---RLCYQAFITV---GNSKVPLDPIVSSPI 248
            :..::.:|.:.|.:||....:     ::...|:|   |||:|  :||   ....:.|.|::|.||
Human   137 LEQAISQRIQTNNNPFQVPIE-----EQRGDYDLNAVRLCFQ--VTVRDPSGRPLRLPPVLSHPI 194

  Fly   249 YG----KSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPT 309
            :.    .::||.|.|:...:.:..|||||.:||:|:.|:||||.|....      |.|...|...
Human   195 FDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPG------WEARGSFSQA 253

  Fly   310 DVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRR 374
            ||.:|:||.|:||.|.:..:...|.|.::|.||||...|.|:.|:|.|:  |....|::.|.||.
Human   254 DVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD--TDDRHRIEEKRKRT 316

  Fly   375 QELDVFQQILSLDSETTATKYSCPPMDLEEDNNTVSSDDQ---------QSSGTLN--EFEIAVK 428
            .|  .|:.|:.....:..|....||..:...:.:.:|..:         .|..|:|  ||...| 
Human   317 YE--TFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMV- 378

  Fly   429 KMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQ---------LADDCTQTSTPMEE 484
                        ...|.:::.:.....|        ||:|||         :.....|...|:..
Human   379 ------------FPSGQISQASALAPAP--------PQVLPQAPAPAPAPAMVSALAQAPAPVPV 423

  Fly   485 ILQHPQLQSRP------LSNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLT 543
            :...|.....|      .:...|::|.:...:|:..|...:       |.|||....||:::|:.
Human   424 LAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGAL-------LGNSTDPAVFTDLASVD 481

  Fly   544 ANTTITNQLDEEAHGLLANG--SRRDTLENPAVKELPENEKEPEMVSASAQASMDLDENFDETAT 606
                     :.|...||..|  ....|.| |.:.|.||                          .
Human   482 ---------NSEFQQLLNQGIPVAPHTTE-PMLMEYPE--------------------------A 510

  Fly   607 YTSLQIAFNNPIDIGLPKESKQAAPIYPPTNPFGQLDDDE 646
            .|.|......|.|       ...||:..|..|.|.|..||
Human   511 ITRLVTGAQRPPD-------PAPAPLGAPGLPNGLLSGDE 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DifNP_001162998.1 RHD-n_Dorsal_Dif 78..252 CDD:143647 71/194 (37%)
RHD_dimer 256..358 CDD:465045 39/101 (39%)
RELANP_001391586.1 RHD-n_RelA 19..198 CDD:143645 71/190 (37%)
IPT_NFkappaB 205..301 CDD:238582 40/101 (40%)
Nuclear localization signal. /evidence=ECO:0000255 312..315 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 320..359 6/38 (16%)
Transcriptional activation domain 3. /evidence=ECO:0000250|UniProtKB:Q04207 353..400 11/67 (16%)
Transcriptional activation domain 1. /evidence=ECO:0000269|PubMed:1732726 426..487 14/76 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..541 8/30 (27%)
Transcriptional activation domain 2. /evidence=ECO:0000250|UniProtKB:Q04207 531..562 6/13 (46%)
9aaTAD. /evidence=ECO:0000255 547..555
Blue background indicates that the domain is not in the aligned region.

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