DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and RELA

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_068810.3	Gene:	RELA / 5970	HGNCID:	9955	Length:	551	Species:	Homo sapiens

Alignment Length:	614	Identity:	178/614 - (28%)
Similarity:	266/614 - (43%)	Gaps:	131/614 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVS 135
            ||:..|||::.|:|:|....:|||||||||:|||||| ..|::|.||.|||::..|.||..:.:|
Human    12 EPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPG-ERSTDTTKTHPTIKINGYTGPGTVRIS 75

  Fly   136 CVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERR 200
            .||.|.|.|.|||.||.|:    |:.|.|:.:|.|:......|.:||||.||.::..::.:|.:.
Human    76 LVTKDPPHRPHPHELVGKD----CRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQT 136

  Fly   201 NIDPFNAKFDHKDQIDKINRYEL---RLCYQAFITV---GNSKVPLDPIVSSPIYG----KSSEL 255
            |.:||....:     ::...|:|   |||:|  :||   ....:.|.|::|.||:.    .::||
Human   137 NNNPFQVPIE-----EQRGDYDLNAVRLCFQ--VTVRDPSGRPLRLPPVLSHPIFDNRAPNTAEL 194

  Fly   256 TITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFK 320
            .|.|:...:.:..|||||.:||:|:.|:||||.|....      |.|...|...||.:|:||.|:
Human   195 KICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPG------WEARGSFSQADVHRQVAIVFR 253

  Fly   321 TPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILS 385
            ||.|.:..:...|.|.::|.||||...|.|:.|:|.|:  |....|::.|.||..|  .|:.|:.
Human   254 TPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD--TDDRHRIEEKRKRTYE--TFKSIMK 314

  Fly   386 LDSETTATKYSCPPMDLEEDNNTVSSDDQ---------QSSGTLN--EFEIAVKKMQMRQRGESH 439
            ....:..|....||..:...:.:.:|..:         .|..|:|  ||...|
Human   315 KSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMV------------ 367

  Fly   440 EMDGGTVTEYTDNDNEPDMEIELEVPQLLPQ---------LADDCTQTSTPMEEILQHPQLQSRP 495
             ...|.:::.:.....|        ||:|||         :.....|...|:..:...|.....|
Human   368 -FPSGQISQASALAPAP--------PQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAP 423

  Fly   496 ------LSNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTITNQLDE 554
                  .:...|::|.:...:|:..|...:       |.|||....||:::|:.         :.
Human   424 PAPKPTQAGEGTLSEALLQLQFDDEDLGAL-------LGNSTDPAVFTDLASVD---------NS 472

  Fly   555 EAHGLLANG--SRRDTLENPAVKELPENEKEPEMVSASAQASMDLDENFDETATYTSLQIAFNNP 617
            |...||..|  ....|.| |.:.|.||                          ..|.|......|
Human   473 EFQQLLNQGIPVAPHTTE-PMLMEYPE--------------------------AITRLVTGAQRP 510

  Fly   618 IDIGLPKESKQAAPIYPPTNPFGQLDDDE 646
            .|       ...||:..|..|.|.|..||
Human   511 PD-------PAPAPLGAPGLPNGLLSGDE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	70/183 (38%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	39/101 (39%)
RELA	NP_068810.3	RHD-n_RelA	19..187	CDD:143645	70/179 (39%)
		IPT_NFkappaB	194..290	CDD:238582	40/101 (40%)
		Nuclear localization signal. /evidence=ECO:0000255	301..304		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..348		6/38 (16%)
		Transcriptional activation domain 3. /evidence=ECO:0000250\|UniProtKB:Q04207	342..389		11/67 (16%)
		Transcriptional activation domain 1. /evidence=ECO:0000269\|PubMed:1732726	415..476		14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..530		8/30 (27%)
		Transcriptional activation domain 2. /evidence=ECO:0000250\|UniProtKB:Q04207	520..551		6/13 (46%)
		9aaTAD. /evidence=ECO:0000255	536..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3890
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm8582
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.990