DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and REL

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_002899.1	Gene:	REL / 5966	HGNCID:	9954	Length:	619	Species:	Homo sapiens

Alignment Length:	656	Identity:	185/656 - (28%)
Similarity:	294/656 - (44%)	Gaps:	131/656 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCV 137
            |....|::.|:|:|....:|||||||||:|||||| ..|::..:|:|:|::.||.|...:.::.|
Human     3 SGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPG-EHSTDNNRTYPSIQIMNYYGKGKVRITLV 66

  Fly   138 TSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNI 202
            |.::|::.|||.||.|:    |:.|.|:.:...|.|.|..|.:||:|.||.|::::::.|.:..|
Human    67 TKNDPYKPHPHDLVGKD----CRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIITRIKAGI 127

  Fly   203 DPFNAKFDHKDQIDKINRYELRLCYQAFI--TVGNSKVPLDPIVSSPIYG----KSSELTITRLC 261
            :|||......:.|:..:...:|||:|.|:  ..||....|.|:||:|||.    .::||.|.|:.
Human   128 NPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRAPNTAELRICRVN 192

  Fly   262 SCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRN 326
            ....:..|||||.:||:|:.||||||||...|      |.|...|...||.:|:||.||||.|..
Human   193 KNCGSVRGGDEIFLLCDKVQKDDIEVRFVLND------WEAKGIFSQADVHRQVAIVFKTPPYCK 251

  Fly   327 TEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSETT 391
            . ||:.|.|:::|.||||...|..:.|.|.|:... |:.   .|.|:::...:||::.....||.
Human   252 A-ITEPVTVKMQLRRPSDQEVSESMDFRYLPDEKD-TYG---NKAKKQKTTLLFQKLCQDHVETG 311

  Fly   392 ATKYSCPPMDL--EEDNNTVSSDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDN 454
            ........::|  ..|..|::|   ||:|....|....:...:...||....           ..
Human   312 FRHVDQDGLELLTSGDPPTLAS---QSAGITVNFPERPRPGLLGSIGEGRYF-----------KK 362

  Fly   455 EPDMEIELEVPQLLPQLADDCTQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERTDSLTV 519
            ||::.....|.:.:|      |..|:..|.....|...|..||:..::.. :.||.:......|.
Human   363 EPNLFSHDAVVREMP------TGVSSQAESYYPSPGPISSGLSHHASMAP-LPSSSWSSVAHPTP 420

  Fly   520 ENGDTQSLSNSTAQTAFTNVSSL-------------TANTTITNQLDE------------EAHG- 558
            .:|:|..||:.:.:|..:|...:             .:|..|.|..|:            :.:|
Human   421 RSGNTNPLSSFSTRTLPSNSQGIPPFLRIPVGNDLNASNACIYNNADDIVGMEASSMPSADLYGI 485

  Fly   559 ----LLAN----------GSRRDT---------LENPAVKEL--PENEKEPEMVSASAQASMDLD 598
                :|:|          .|..:|         ||||:...:  |.:.::...:|:|   ||...
Human   486 SDPNMLSNCSVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRDLRQLHQMSSS---SMSAG 547

  Fly   599 ENFDETATYTSLQIAF---------NNPIDIGLPKESKQAAPIYPPTNP-------------FGQ 641
            .| ..|..:.|...||         |:.|:...|..|         |||             .|.
Human   548 AN-SNTTVFVSQSDAFEGSDFSCADNSMINESGPSNS---------TNPNSHGFVQDSQYSGIGS 602

  Fly   642 LDDDEL 647
            :.:::|
Human   603 MQNEQL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	68/179 (38%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	44/101 (44%)
REL	NP_002899.1	RHD-n_c-Rel	8..179	CDD:143649	68/175 (39%)
		RHD_dimer	187..282	CDD:292797	44/101 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	290..295		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..437		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..593		7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMKZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm8582
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810