DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dif and NFKB2

DIOPT Version :10

Sequence 1:NP_001162998.1 Gene:Dif / 35045 FlyBaseID:FBgn0011274 Length:987 Species:Drosophila melanogaster
Sequence 2:NP_001070962.1 Gene:NFKB2 / 4791 HGNCID:7795 Length:900 Species:Homo sapiens


Alignment Length:942 Identity:226/942 - (23%)
Similarity:343/942 - (36%) Gaps:304/942 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 PEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETG-KTFPTIEVCNYDGPVIIV 133
            |.|....||:|.|||:|.....||||.|||.:.|.:||  :|||.| ||:||:::|||:||..|.
Human    30 PAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPG--ASSEKGRKTYPTVKICNYEGPAKIE 92

  Fly   134 VSCVTSDEPFRQHPHWLVSKEEADACKS-GIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLV-- 195
            |..||..:|.|.|.|.||.|:    |.. ||....:.|::.......:|:....|..|..:::  
Human    93 VDLVTHSDPPRAHAHSLVGKQ----CSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQK 153

  Fly   196 --------------ERERRNIDPFNAKFDHKDQIDKINRYEL-RLCYQAFITV--GNSKVPLDPI 243
                          |.|:|.::. .||     ::.|:....: ||.:.||:..  |:..:||.|:
Human   154 LQRQRLRSRPQGLTEAEQRELEQ-EAK-----ELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPV 212

  Fly   244 VSSPIYGK----SSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANA 304
            :|.||:..    :|.|.|:|:...|.:..||||:.:||:|:.||||||||||.|::|   |.|..
Human   213 ISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQAFG 274

  Fly   305 EFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQR 369
            :|.||||.||.||.|:||.|...:|.:.|.|.|:|.|...|..|....|.|||    :...:.:.
Human   275 DFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYP----LVEDKEEV 335

  Fly   370 KLKRRQELDVFQQ---------------------------------------------------- 382
            :.|||:.|..|.|                                                    
Human   336 QRKRRKALPTFSQPFGGGSHMGGGSGGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPG 400

  Fly   383 ----------ILSLDSETTATKYSCPPMDLEEDNNTVSSDDQQSSGTLNEFEIAVKKMQMRQRGE 437
                      :.|.||...|.:.|.|       :.|...:.|.........|...:...:.||..
Human   401 GGGGAQMAATVPSRDSGEEAAEPSAP-------SRTPQCEPQAPEMLQRAREYNARLFGLAQRSA 458

  Fly   438 SHEMDGGTVTE-----------YTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEI---LQH 488
            ...:|.|...:           .|..|...|..:.|.:..         .|||. :|:|   :.|
Human   459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIH---------GQTSV-IEQIVYVIHH 513

  Fly   489 PQLQSRPLSNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTITNQL- 552
            .|                         .|.|.|     |:|...||.. :::.:|..|::.:.| 
Human   514 AQ-------------------------DLGVVN-----LTNHLHQTPL-HLAVITGQTSVVSFLL 547

  Fly   553 -------------DEEAHGLLANGS-----RRDTLEN--PAVKEL---PENE-----------KE 583
                         |...|..|..|:     .|..|::  |||.:|   |:.|           :.
Human   548 RVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARS 612

  Fly   584 PE----MVSASAQ----------ASMDLDENFDETATYTSL-----------QIAFNNPI----D 619
            ||    :|.:.|:          .::.|....:|....|.|           ..|.|.|:    .
Human   613 PECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAG 677

  Fly   620 IGLPK------------ESKQAAPIYP-PTNPFGQLDDDE----------------LVVLTNPPA 655
            :|.|.            .::...|:.| |:.|....|.|.                |.:..:...
Human   678 LGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKV 742

  Fly   656 PRIKVNAAQTPATPPASPPLPLPPRTPSPVSDQRLPPLP-----PKPQRNSQDLS------AVSD 709
            ..:.:||||....||.:||.|..|..  .:.|..|..|.     |:.|.:..:|:      ::.|
Human   743 KTLLLNAAQNTMEPPLTPPSPAGPGL--SLGDTALQNLEQLLDGPEAQGSWAELAERLGLRSLVD 805

  Fly   710 SISVSRSRNGSL-----------------SSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQG 757
            :...:.|.:|||                 .|:......:.::|.|:    .|...||.:..|...
Human   806 TYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPE----TRDKLPSTAEVKEDS 866

  Fly   758 FFSRFFSRRRSKTDDEESLTPGGSPNKQLPGG 789
            .:.     .:|...:.|.|.|...|    |||
Human   867 AYG-----SQSVEQEAEKLGPPPEP----PGG 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DifNP_001162998.1 RHD-n_Dorsal_Dif 78..252 CDD:143647 64/198 (32%)
RHD_dimer 256..358 CDD:465045 48/101 (48%)
NFKB2NP_001070962.1 RHD-n_NFkB2 38..221 CDD:143650 64/194 (33%)
IPT_NFkappaB 228..327 CDD:238582 48/101 (48%)
Nuclear localization signal. /evidence=ECO:0000255 337..341 2/3 (67%)
GRR 346..377 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..435 7/37 (19%)
ANKYR 438..706 CDD:440430 53/308 (17%)
ANK repeat 487..524 CDD:293786 13/76 (17%)
ANK 1 487..519 10/66 (15%)
ANK repeat 526..557 CDD:293786 5/31 (16%)
ANK 2 526..555 5/29 (17%)
ANK 3 559..591 9/31 (29%)
ANK repeat 559..586 CDD:293786 6/26 (23%)
ANK repeat 599..630 CDD:293786 5/30 (17%)
ANK 4 599..628 5/28 (18%)
ANK repeat 633..665 CDD:293786 4/31 (13%)
ANK 5 633..663 4/29 (14%)
ANK repeat 667..698 CDD:293786 5/30 (17%)
ANK 6 667..696 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..734 6/35 (17%)
ANK 7 729..758 6/28 (21%)
Death_NFkB2_p100 774..849 CDD:176776 11/74 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..900 13/54 (24%)

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