DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and nfkb2

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001005032.1	Gene:	nfkb2 / 448550	XenbaseID:	XB-GENE-970084	Length:	946	Species:	Xenopus tropicalis

Alignment Length:	1030	Identity:	230/1030 - (22%)
Similarity:	374/1030 - (36%)	Gaps:	286/1030 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETG-KTFPTIEVCNYDGPVIIVVSCVTSDEPF 143
            |.|:|:|.....||||.|||.:.|.:||  :|||.| ||:||:::.||.|...|.|..||..:|.
Frog    45 LSIIEQPKQRGFRFRYVCEGPSHGGLPG--ASSEKGKKTYPTVKIFNYVGMARIEVDLVTHIDPP 107

  Fly   144 RQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGI-QCAKKLEM----------------R 191
            |.|.|.||.|...:   :|.....:.||:.......:|| ...||.:.                |
Frog   108 RVHAHSLVGKHSNE---TGNCVVTVGPEDMTAQFNNLGIVHVTKKSQTEILKEKMKRQILRHTGR 169

  Fly   192 DSLVERERRNIDPFNAKFDHKDQIDKINRYEL-RLCYQAFITVGNS--KVPLDPIVSSPIYGK-- 251
            :.|.|.|.|.|:      ....::.|:....: ||.:.|::...|.  .:.|.|::|.||:..
Frog   170 NLLTEAEERRIE------QEVKELKKVTDLSIVRLRFTAYLPDSNGAYTLGLPPVISDPIHDSKS 228

  Fly   252 --SSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQ 314
              :|.|.|:|:...|.:..||||:.:||:|:.||||||||||.|::|   |.:..:|.||||.||
Frog   229 PGASNLRISRMDKTAGSVKGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQSFGDFAPTDVHKQ 290

  Fly   315 MAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDV 379
            .||.|:||.|...:|.:.|.|.|:|.|...|..|....|.|||    :...:.:...|||::|..
Frog   291 YAIVFRTPPYHTQKIDRPVTVFLQLKRKKGGDVSDSKQFTYYP----LEQDKEEVDRKRRKDLPT 351

  Fly   380 F------------------------------------------------------QQILSLDSET 390
            |                                                      ..:....:..
Frog   352 FNNHFFGGGSPMGGAGGGSSFGQGGGGSNINYPYPGMQTAFYMSSPAGGGYHSSGHMMKHCSAAN 416

  Fly   391 TATKYSCPPMDLEEDNNTVSSDDQQSSGTLNEFEIA------------VKKMQMRQRGESHEMDG 443
            ::.|...|.::::::....|:..||:..|..:.|..            ::.:.:.||.....:|.
Frog   417 SSEKNQAPSINIKKEGEEASACSQQARSTSAQKETQCQMIMHQANLCNMRMLSLTQRTSRALLDY 481

  Fly   444 GTVTE-----------YTDNDNEPDMEIELEVPQLLPQLADDCTQT--STPMEEIL-QHPQLQSR 494
            ....:           ....|...|..:.|.|....|.:.:...|.  |.|.::|| ....||..
Frog   482 AITADPRMLLAVQRHLIATQDENGDTPLHLAVIHGQPSVIEQLVQVIISIPNQQILNMSNHLQQT 546

  Fly   495 PLSNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTITNQLDEEAHGL 559
            || ::..||:......|              .|......|......:...:..:..:.|:....|
Frog   547 PL-HLGVITKQYSVVAF--------------LLKAGADPTILDRYGNSVLHLAVQAEDDKMLSVL 596

  Fly   560 LANGS--RRDTLENP----------AVKELPENEKEPE-MVSASAQASMDLDENFDETATYTSLQ 611
            |...|  ::|.|..|          :||  .:|||..| :|.|.|
Frog   597 LKYPSVGQKDLLNMPDYHGLCPVHWSVK--MKNEKCLELLVKAGA-------------------- 639

  Fly   612 IAFNNPIDIGLPKESKQAAPIYPPTNPFGQLDDDELVVLTNPPAPRIKVNAAQTPA-TPPASPPL 675
                   ::..|:.....:|::...    ::|:..:.:..      :|.:.|...| |...:.||
Frog   640 -------NVNSPERKSGKSPLHIAV----EMDNLNMAIFL------VKKSHADINAKTYGGNTPL 687

  Fly   676 PLPPRTPSPVSDQRL------------PPLPPKPQRNSQDLSAVSD-SISVSRSRNGSLSSNRTT 727
            .|.....||:..:.|            .|:...|..||....:.|| .:......:|...::.:|
Frog   688 HLAASRGSPMLTKMLVNEGANVLSENDEPVNKLPSCNSDTSESDSDVQMDTDSDHHGGSDTDSST 752

  Fly   728 PSPIIIMRTPDQSPTKRQP--TPSASPKKR-QGFFSRFFSRRRSKTDDEESLTPGGSPNKQLPGG 789
            ........:.::..:|.|.  .|..:.|:| .|..:...::.:...|.....|||.:..|:
Frog   753 AVDSDCEHSAEEMHSKEQRGIRPHCAVKRRYPGHTALDLTKSQKVRDILSKHTPGSASWKR---- 813

  Fly   790 SKATTPTGSREPS-VAHFSLGDPNRSSTRSMQPLGK--SEGRNGKPVGRSSSSVSGKRPAHLDAD 851
                     |||. |...:|      .|.::|.|.|  :||:.|                   ||
Frog   814 ---------REPEPVNVLAL------ETNTVQRLEKLLNEGQTG-------------------AD 844

  Fly   852 VIHIPLKGGDSENSLLR----PESYSNASTLSYGRPLDRKTLSTLQLADIPISDGNMELIAIADR 912
            ...:.        |.||    .|:|.|.|:     |.: ..|.:.:||...:::....|.::...
Frog   845 WTELA--------SRLRLQSLVETYRNTSS-----PTE-SLLRSYELAGGSLTELINTLQSMGLN 895

  Fly   913 QSIKNLCEG-AYGVVLDPS--------------VDLSEAEHFALYTSKSPEPPFG 952
            :.::.||:. .|.....|:              ||.|.||     .|.:.||..|
Frog   896 KGVELLCKSETYAKHQSPAEGKNDSAYESQSMEVDQSSAE-----LSPTTEPAIG 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	59/196 (30%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	47/101 (47%)
nfkb2	NP_001005032.1	RHD-n_NFkB2	44..227	CDD:143650	59/192 (31%)
		RHD_dimer	235..334	CDD:292797	48/105 (46%)
		Ank_4	476..525	CDD:290365	6/48 (13%)
		ANK	501..635	CDD:238125	32/150 (21%)
		ANK repeat	504..541	CDD:293786	9/36 (25%)
		ANK repeat	543..574	CDD:293786	9/45 (20%)
		Ank_2	548..642	CDD:289560	22/137 (16%)
		ANK	572..703	CDD:238125	28/169 (17%)
		ANK repeat	614..645	CDD:293786	9/59 (15%)
		Ank_2	620..713	CDD:289560	22/131 (17%)
		ANK repeat	648..680	CDD:293786	5/41 (12%)
		ANK repeat	682..707	CDD:293786	6/24 (25%)
		Death_NFkB2_p100	828..903	CDD:176776	21/107 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6215
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020