Protein Alignment Dif and rel

DIOPT Version :9

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: NP_001001841.2
• Gene: rel / 415101
• ZFINID: ZDB-GENE-040718-255
• Length: 596
• Species: Danio rerio
• Alignment Length: 652
• Identity: 191/652 - (29%)
• Similarity: 290/652 - (44%)
• Gaps: 137/652 - (21%)

  Fly    58 LHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIE 122
            :.:|:.:|::   :|.....|.::|.|:|....:|||||||||:|||||| ..||:..:|:|:|:
Zfish     1 MDVQSLSMHR---DPHLMGEPCVQIFEQPKQRGMRFRYKCEGRSAGSIPG-ERSSDNNRTYPSIQ 61

  Fly   123 VCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKK 187
            :.|..|...:.|:.||..||::.|||.||.|:    ||.|.|:.:..||.|.:..|.:||||.::
Zfish    62 ILNVTGKGKVRVTLVTKSEPYKPHPHDLVGKD----CKDGYYEAEFGPERRAIAFQNLGIQCVRR 122

  Fly   188 LEMRDSLVERERRNIDPFNAKFDHKDQIDKINRYEL---RLCYQAFI--TVGNSKVPLDPIVSSP 247
            .|::|::::|..|.|:|||..   ::|:.:...|:|   |||:|.::  ..|.....|.||||:|
Zfish   123 REVKDAIMQRVTRGINPFNVP---REQLLQTEEYDLNVVRLCFQIYLQDESGMYSTMLPPIVSNP 184

  Fly   248 IYG----KSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQP 308
            ||.    .::||.|.|:...:.:..|||||.:||:|:.||||||||:      .:||.|...|..
Zfish   185 IYDNRAPNTAELRICRVNKNSGSVKGGDEIFLLCDKVQKDDIEVRFF------TQTWEAKGSFSQ 243

  Fly   309 TDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNP----GTVTFARLQR 369
            .||.:|:||.||||.|.:|.||..|.|.::|.||:|...|.|:.|.|.|:.    |.       |
Zfish   244 ADVHRQVAIVFKTPAYCDTSITAPVTVRMQLRRPTDQEVSEPMEFRYLPDDKDPYGC-------R 301

  Fly   370 KLKRRQELDV-------FQQILSLDSETTATKYSC---------PPMDLEEDNNTVSSDDQQSSG 418
            :.||:.::.:       .|:.:|..:.|.|...:.         ||......|..|:..:|..
Zfish   302 EKKRKIDMQMKSSFPSFSQEAMSFMNRTKAVSSTNLMNQRIKTEPPNFYRPPNQGVARQNQPV-- 364

  Fly   419 TLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPME 483
               .:...::...|..........|.                       |.|.....|.||.|..
Zfish   365 ---YYNKGLRSCPMMPHPSETTTQGA-----------------------LSQWTSQVTNTSVPNN 403

  Fly   484 EI-LQHPQLQSRPLSNVETITEWMKSSEFERTDSLTVE----NGDT-----QSLSNSTAQT---- 534
            .: ||    |..|..|:.:..|  ..:......|:.:|    ||.|     |.|.|...|.
Zfish   404 VVSLQ----QVNPSPNMPSAGE--NGNSLPLLTSMDLEILQPNGPTGNQPRQDLLNQQVQQSQQP 462

  Fly   535 --------AFTNVSSLTANTTITNQLDEEAHGLLANGSR-RDTLENPAVKELPEN-------EKE 583
                    |:.|.||.....|....  ..|.|.||.|.: ...||:..::.|..|       ::|
Zfish   463 PQRQGQEGAWYNYSSQQPQNTQNGA--SGASGSLATGYQFTSGLEDDILQSLMGNHQPGIQLKQE 525

  Fly   584 PEMVSASAQASMDLDENFDETATYTSLQIAFNNPIDIGLPKESKQAAP---------IYPPTNPF 639
            |:.:|..|..     .|.|...::|:| :..||.   ..|:..:|..|         |..|:...
Zfish   526 PQGLSNMAPL-----VNSDCVQSFTAL-LNCNNG---STPEHMRQIDPNGANQRVSQIQYPSGNM 581

  Fly   640 GQ 641
            ||
Zfish   582 GQ 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	73/182 (40%)
		RHD_dimer	256..358	CDD:292797	45/101 (45%)
rel	NP_001001841.2	RHD-n_c-Rel	18..189	CDD:143649	73/178 (41%)
		RHD_dimer	197..293	CDD:292797	45/101 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593307
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	1	0.900	-	-		E1_2CMKZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3492
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm6520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860