DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dif and nfkb2

DIOPT Version :9

Sequence 1:NP_001162998.1 Gene:Dif / 35045 FlyBaseID:FBgn0011274 Length:987 Species:Drosophila melanogaster
Sequence 2:NP_001001840.2 Gene:nfkb2 / 415100 ZFINID:ZDB-GENE-030131-6701 Length:902 Species:Danio rerio


Alignment Length:872 Identity:206/872 - (23%)
Similarity:322/872 - (36%) Gaps:245/872 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 LPVMPSHIPL-HLQNQNMNQNLPEPSAR---SGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMN 109
            ||.||....: |           ||..:   .||:::|:|||.....||||:|||.:.|.:||. 
Zfish    31 LPYMPEAFEVKH-----------EPFVQETVDGPYIQIIEEPKQRGFRFRYECEGPSHGGLPGA- 83

  Fly   110 SSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADAC-KSGIYQKKLPPEER 173
            ||....:|:||::|.|:.|...:.|..||..:|.|.|.|.||.:.    | :||:....:.|.:.
Zfish    84 SSERNRRTYPTVKVLNFVGNARVEVQLVTHTDPPRVHAHSLVGRH----CNESGVCSVDVGPSDF 144

  Fly   174 RLVLQKVGIQCAKK---LEMRDSLVERERRNIDPFNAKF----------DHKDQIDKINRYELRL 225
            ......:||....|   :|:....::.|:|.:.....||          :.|:....::...:||
Zfish   145 TAQFSNLGILHVTKRGVVEVLTKRLKEEKRKVKGPGYKFSDAEENALMQEAKELGKNMDLNIVRL 209

  Fly   226 CYQAFITVGNSKV--PLDPIVSSPIYG----KSSELTITRLCSCAATANGGDEIIMLCEKIAKDD 284
            .:.|::...|...  .|.|:||:|||.    .:|.|.|:|:...:.:..||:|:.:||:|:.|||
Zfish   210 KFTAYLQDSNGSYTRALKPVVSNPIYDSKSPNASNLKISRMDKTSGSVLGGEEVFLLCDKVQKDD 274

  Fly   285 IEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSA 349
            |::||||.:    :.|.|..:|.||||.||.||.||||.||.|.|.:.|.|.|:|.|...|..|.
Zfish   275 IDIRFYEEE----DEWEALGDFSPTDVHKQYAIVFKTPPYRCTNIDRPVTVFLQLKRKKGGDCSE 335

  Fly   350 PLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCP---------------- 398
            |..|.|.|:  ......:||  ||.:.|...........:..|..:..|                
Zfish   336 PKQFTYVPH--NQDKEEVQR--KRMKALPDHYGGWRGGPQGGAGGFGGPGSGTGGGGGMGGGFPF 396

  Fly   399 -PMDLEEDNNTVSSDDQQSS---GTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDME 459
             |||             .||   |....|           .|.:...|....|:..:..::.:.:
Zfish   397 NPMD-------------NSSFFVGGCGGF-----------GGGAQMSDSPPQTDGANTQSQSNSQ 437

  Fly   460 IELEVPQLL----PQLADDCTQTSTPMEEILQHPQL-QSRPLSNVETITEWMKSSEFERTDSLTV 519
            |..::.|:.    ..||..|...:     :||:... .:|||..::           .....:..
Zfish   438 IRQQLIQIALHNRANLAAKCNARA-----LLQYSSTGDARPLLALQ-----------RHLCGVQD 486

  Fly   520 ENGDT------------------QSLSNSTAQTAFTNVSSLTAN----TTITNQ----------- 551
            |||||                  ::|::|..|..|..::.|:..    ..||.|           
Zfish   487 ENGDTPLHLAIIHQKTVVAEQLIKALNSSPQQKFFNKLNKLSQAPLHLAVITKQPKLVEMLMKSG 551

  Fly   552 -----LDEEAHGL--LANGSRRDTLENPAVKELPENEKEPEMVSASAQASMDLDENFDETATYTS 609
                 ||.|...:  ||..:..|.:....:..|.|:...             |..:.|.|..|  
Zfish   552 ADPSLLDREGRTVLHLAAHTGDDVILRLVLSLLGEHHSH-------------LINSADFTGQY-- 601

  Fly   610 LQIAFNNPIDIGLPKESKQ--------AAPIYPPTNPFG------QLDDDELVVLTNPPAP-RIK 659
                   |:.:.:.|:.::        .|.|..|....|      .:.|:.|.:..|.... :..
Zfish   602 -------PVHLAVKKDGERCLRLLVEAGAKINMPEQKSGCTALHLAVRDNLLKLACNLITELKAD 659

  Fly   660 VNAAQTPATPPASPPLPLPPRTPSP---------VSDQRLPPLPPKPQRNSQDL---SAVSDSIS 712
            |||    .|...:.||.|.....||         .:|:|:        .|.:.|   |:.||...
Zfish   660 VNA----CTYGGNSPLHLAASQGSPHLCSMLIAAGADKRI--------ENDEPLFLSSSSSDEDE 712

  Fly   713 VSRSRNG----------SLSSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQGFFSRFFSRRR 767
            .|..:..          |:||.|...:|            :::|....:|         |...:.
Zfish   713 ESEKKLSEDMVQQVHCLSISSERGVFNP------------RKRPAAGHTP---------FDLAKS 756

  Fly   768 SKTDDEESLTPGGSPNKQLPGGSKATT 794
            .|..|......|..||...|..:|.:|
Zfish   757 QKVRDLLDGRKGPKPNSLSPKRTKIST 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DifNP_001162998.1 RHD-n_Dorsal_Dif 78..252 CDD:143647 56/193 (29%)
RHD_dimer 256..358 CDD:292797 45/101 (45%)
nfkb2NP_001001840.2 RHD-n_NFkB2 53..238 CDD:143650 56/189 (30%)
RHD_dimer 246..344 CDD:292797 45/101 (45%)
Ank_2 <483..558 CDD:289560 13/74 (18%)
ANK 485..619 CDD:238125 27/155 (17%)
ANK repeat 488..525 CDD:293786 8/36 (22%)
ANK repeat 528..558 CDD:293786 3/29 (10%)
Ank_2 532..627 CDD:289560 19/116 (16%)
ANK 558..687 CDD:238125 29/154 (19%)
ANK repeat 560..596 CDD:293786 7/48 (15%)
ANK repeat 599..629 CDD:293786 5/38 (13%)
Ank_2 604..697 CDD:289560 19/104 (18%)
ANK repeat 632..664 CDD:293786 7/35 (20%)
ANK repeat 666..697 CDD:293786 7/38 (18%)
Death_NFkB2_p100 794..867 CDD:176776
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I6490
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D391433at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24169
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
44.020

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