DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and rela

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_005170853.1	Gene:	rela / 415099	ZFINID:	ZDB-GENE-040825-4	Length:	588	Species:	Danio rerio

Alignment Length:	516	Identity:	162/516 - (31%)
Similarity:	262/516 - (50%)	Gaps:	81/516 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEP 142
            ||:.|:|:|.|..:|||||||||:|||||| ..|::|.||.|.|.|.||.|||.:.:|.||.::|
Zfish    18 PHVEIIEQPKSRGMRFRYKCEGRSAGSIPG-EKSNDTTKTHPAIRVHNYSGPVRVRISLVTKNQP 81

  Fly   143 FRQHPHWLVSKEEADACKSGIYQKKLPPEERRL-VLQKVGIQCAKKLEMRDSLVERERRNIDPFN 206
            ::.|||.||.|:    ||.|.|:..|  :|||: ..|.:||||.||.::.:::..|.:...:||.
Zfish    82 YKPHPHELVGKD----CKHGYYEADL--QERRIHSFQNLGIQCVKKKDVGEAVSCRLQTQNNPFK 140

  Fly   207 AKFDHKDQIDKINRYELRLCYQAFITVGNSKV-PLDPIVSSPIYG----KSSELTITRLCSCAAT 266
            .. |.|...::.:...:|||:|..||:.:..: ||:|:||.|||.    .::||.|.|:...:.:
Zfish   141 IP-DAKIWEEEFDLNAVRLCFQVSITLSSGDLFPLEPVVSQPIYDNRAPNTAELKICRVNRNSGS 204

  Fly   267 ANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQ 331
            ..|||||.:||:|:.|:||||||:      .::|.:...|...||.:|:||.|:||.|.:|.:|:
Zfish   205 CRGGDEIFLLCDKVQKEDIEVRFF------LDSWESKGSFSQADVHRQVAIVFRTPPYCDTNLTE 263

  Fly   332 SVNVELKLVRPSDGATSAPLPFEYYP-NPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKY 395
            .:.|:::|.||||...|.|:.|:|.| :|..      .|.:::|:..:.....|.|.|..|.:..
Zfish   264 PLRVKMQLRRPSDREVSEPMDFQYLPSDPDE------HRLMEKRKRTEGMLHNLKLSSIITGSSM 322

  Fly   396 SCPPMDLEEDNNTVSSDDQQSSGTLNEFEIAVK------------------KMQMRQRGESHEMD 442
            |...........|:....|..:.:......||.                  ::..:|:.|...:.
Zfish   323 SAERRPFPTAKRTLPVSKQPVAASAPASVPAVSAAPPLKPPPTSFFSPPPGQLFTQQKMEPSPLP 387

  Fly   443 GGT--VTEYTDN---DNEPDM---------EIELEVPQLLPQ------LAD--DCT-QTST---- 480
            ..:  :.:|...   |::|..         .:...:|..|.|      |:|  ||| ::||
Zfish   388 ASSSDIWKYLQAMSVDSQPKAVPVLPFPSGTVSTALPTCLTQAFPTVNLSDLHDCTIKSSTIAEP 452

  Fly   481 -PMEEILQHPQLQSR---PLSNV---ETITEWMKSSEFERTDSLTVENGDTQS-LSNSTAQ 533
             |:::....|::||.   .::|.   |.:.::...||.:.:.. ::.|.|.|: |..||.|
Zfish   453 APLKDPEPAPEVQSAFTIRMNNTFPDENLPDFPSFSELQGSGD-SISNEDIQAILDQSTRQ 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	77/179 (43%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	41/102 (40%)
rela	XP_005170853.1	RHD-n_RelA	18..186	CDD:143645	77/175 (44%)
rela	XP_005170853.1	IPT_NFkappaB	193..289	CDD:238582	41/101 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593303
Domainoid	1	1.000	106	1.000	Domainoid score	I6490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3492
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm6520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.000