Protein Alignment Dif and Rel

DIOPT Version :10

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: NP_477094.1
• Gene: Rel / 41087
• FlyBaseID: FBgn0014018
• Length: 971
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 194/762 - (25%)
• Similarity: 296/762 - (38%)
• Gaps: 232/762 - (30%)

  Fly    53 PSHIPLHLQNQNMNQN--LPEPSARSGPHLRIVEEPTSNIIRFRYKCEGR-TAGSIPGMNSSSET 114
            |:.:| ..||...:||  ..:...:..|.|||||:|... .|||||.|.. |.||:.|.| |..|
  Fly   124 PATVP-PSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGAN-SKRT 185

  Fly   115 GKTFPTIEVCNYDGPVIIVVSCVTS--DEPFRQHPHWL-VSKEEADAC-KSGIYQKKLPPEERRL 175
            .||||.:.:||||||.:|..|...:  |.|   |.|.| |.|::.|.| ...::..|    ||..
  Fly   186 PKTFPEVTLCNYDGPAVIRCSLFQTNLDSP---HSHQLVVRKDDRDVCDPHDLHVSK----ERGY 243

  Fly   176 VLQKVG---IQCAKKLEMRDSLVERERRNIDPFNAK-FDHKD----------QIDKINRYELRLC 226
            |.|.:.   |..|||....:...:::.|.:...|.: ..||.          :...:|..::|||
  Fly   244 VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLC 308

  Fly   227 YQAF-ITVGNSKVPLDPIVSSPIY---------GKSSELTITRLCSCAATANGGDEIIMLCEKIA 281
            ::|| |....:.|||.|    |:|         .::.||.|.||........|.||:|:|.||::
  Fly   309 FEAFKIEDNGAWVPLAP----PVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVS 369

  Fly   282 KDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGA 346
            |.:|:|||:|.|:||...|.|.|:|:.:||..|.||..:||.|::.::.:.|||.::|:||||..
  Fly   370 KKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDE 434

  Fly   347 TSAP-LPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCPPMDLEEDNNTVS 410
            .|.| |||.|  .|.:|..:|     |||:                                |.|
  Fly   435 RSFPALPFRY--KPRSVIVSR-----KRRR--------------------------------TGS 460

  Fly   411 SDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDC 475
            |.:..|||                            ||.::|        .|::|:.|     ..
  Fly   461 SANSSSSG----------------------------TESSNN--------SLDLPKTL-----GL 484

  Fly   476 TQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERT---DSLTVEN------GDTQSLSNST 531
            .|....:..:.||.|..|......:.:.|::.|.:|.:.   :|..:|.      |:.|...::.
  Fly   485 AQPPNGLPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDGHNR 549

  Fly   532 AQTAFTNVSSLTANTTITNQLDE------------------------EAHGLLANGSRRDTLENP 572
            |:.....      |.|| ..||:                        ..|.|  |...||||
  Fly   550 AEVPSHR------NRTI-KCLDDLFEIYKQDRISPIKISHHKVEKWFIEHAL--NNYNRDTL--- 602

  Fly   573 AVKELPENEKEPEMVSASAQASMDLDENFDETATYTSLQIAFNNPID------IGLPKESKQAAP 631
             :.|:..::|:          .:.|.....:...|.:|:...|:.::      :.:..:..:|..
  Fly   603 -LHEVISHKKD----------KLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHY 656

  Fly   632 IYPPTNPFGQLDDDELVVLTNPPAPRIKVNAAQTP------------------ATPPASPPLPLP 678
            |.|              :|.....|.:|.||..||                  ..|.....|.|
  Fly   657 IRP--------------LLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSL- 706

  Fly   679 PRTPSPVSDQRLPPLPPKPQRNSQD-----LSAVSDSISVSRSRNGS 720
                  .:|..|.||....::|..|     :|....||||:.:.:|:
  Fly   707 ------TNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGN 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	67/202 (33%)
		RHD_dimer	256..358	CDD:465045	45/102 (44%)
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	67/198 (34%)
		IPT_NFkappaB	343..446	CDD:238582	46/104 (44%)
		ANKYR	590..805	CDD:440430	38/195 (19%)
		ANK repeat	640..671	CDD:293786	5/44 (11%)
		ANK repeat	673..708	CDD:293786	6/41 (15%)