DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and Rel

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_477094.1	Gene:	Rel / 41087	FlyBaseID:	FBgn0014018	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	194/762 - (25%)
Similarity:	296/762 - (38%)	Gaps:	232/762 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PSHIPLHLQNQNMNQN--LPEPSARSGPHLRIVEEPTSNIIRFRYKCEGR-TAGSIPGMNSSSET 114
            |:.:| ..||...:||  ..:...:..|.|||||:|... .|||||.|.. |.||:.|.| |..|
  Fly   124 PATVP-PSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEK-FRFRYKSEMHGTHGSLNGAN-SKRT 185

  Fly   115 GKTFPTIEVCNYDGPVIIVVSCVTS--DEPFRQHPHWL-VSKEEADAC-KSGIYQKKLPPEERRL 175
            .||||.:.:||||||.:|..|...:  |.|   |.|.| |.|::.|.| ...::..|    ||..
  Fly   186 PKTFPEVTLCNYDGPAVIRCSLFQTNLDSP---HSHQLVVRKDDRDVCDPHDLHVSK----ERGY 243

  Fly   176 VLQKVG---IQCAKKLEMRDSLVERERRNIDPFNAK-FDHKD----------QIDKINRYELRLC 226
            |.|.:.   |..|||....:...:::.|.:...|.: ..||.          :...:|..::|||
  Fly   244 VAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLC 308

  Fly   227 YQAF-ITVGNSKVPLDPIVSSPIY---------GKSSELTITRLCSCAATANGGDEIIMLCEKIA 281
            ::|| |....:.|||.|    |:|         .::.||.|.||........|.||:|:|.||::
  Fly   309 FEAFKIEDNGAWVPLAP----PVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVS 369

  Fly   282 KDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGA 346
            |.:|:|||:|.|:||...|.|.|:|:.:||..|.||..:||.|::.::.:.|||.::|:||||..
  Fly   370 KKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDE 434

  Fly   347 TSAP-LPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCPPMDLEEDNNTVS 410
            .|.| |||.|  .|.:|..:|     |||:                                |.|
  Fly   435 RSFPALPFRY--KPRSVIVSR-----KRRR--------------------------------TGS 460

  Fly   411 SDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDC 475
            |.:..|||                            ||.::|        .|::|:.|     ..
  Fly   461 SANSSSSG----------------------------TESSNN--------SLDLPKTL-----GL 484

  Fly   476 TQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERT---DSLTVEN------GDTQSLSNST 531
            .|....:..:.||.|..|......:.:.|::.|.:|.:.   :|..:|.      |:.|...::.
  Fly   485 AQPPNGLPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDGHNR 549

  Fly   532 AQTAFTNVSSLTANTTITNQLDE------------------------EAHGLLANGSRRDTLENP 572
            |:.....      |.|| ..||:                        ..|.|  |...||||
  Fly   550 AEVPSHR------NRTI-KCLDDLFEIYKQDRISPIKISHHKVEKWFIEHAL--NNYNRDTL--- 602

  Fly   573 AVKELPENEKEPEMVSASAQASMDLDENFDETATYTSLQIAFNNPID------IGLPKESKQAAP 631
             :.|:..::|:          .:.|.....:...|.:|:...|:.::      :.:..:..:|..
  Fly   603 -LHEVISHKKD----------KLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHY 656

  Fly   632 IYPPTNPFGQLDDDELVVLTNPPAPRIKVNAAQTP------------------ATPPASPPLPLP 678
            |.|              :|.....|.:|.||..||                  ..|.....|.|
  Fly   657 IRP--------------LLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSL- 706

  Fly   679 PRTPSPVSDQRLPPLPPKPQRNSQD-----LSAVSDSISVSRSRNGS 720
                  .:|..|.||....::|..|     :|....||||:.:.:|:
  Fly   707 ------TNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGN 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	67/202 (33%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	45/102 (44%)
Rel	NP_477094.1	RHD-n_Relish	150..336	CDD:143644	67/198 (34%)
		IPT_NFkappaB	343..446	CDD:238582	46/104 (44%)
		ANK	638..766	CDD:238125	25/131 (19%)
		ANK repeat	640..671	CDD:293786	5/44 (11%)
		Ank_4	641..691	CDD:290365	10/63 (16%)
		ANK repeat	673..708	CDD:293786	6/41 (15%)
		Ank_2	678..775	CDD:289560	15/77 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17146at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950