Protein Alignment Dif and rela

DIOPT Version :10

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: XP_012816239.2
• Gene: rela / 407869
• XenbaseID: XB-GENE-946506
• Length: 534
• Species: Xenopus tropicalis
• Alignment Length: 564
• Identity: 172/564 - (30%)
• Similarity: 260/564 - (46%)
• Gaps: 117/564 - (20%)

  Fly    48 SLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSS 112
            |..||||                     |.||:.|:|:|....:|||||||||:|||||| ..|:
 Frog    14 SSTVMPS---------------------SHPHVEIIEQPKQRGMRFRYKCEGRSAGSIPG-ERST 56

  Fly   113 ETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVL 177
            :|.||.|||::.:|.|...|.:|.||.|.|.:.|||.||.|:    ||.|.|:.:|.|:......
 Frog    57 DTTKTHPTIKINHYQGSARIRISLVTKDSPHKPHPHELVGKD----CKDGYYEAELSPDRSIHSF 117

  Fly   178 QKVGIQCAKKLEMRDSLVERERRNIDPFNA-----KFDHKDQIDKINRYELR---LCYQAFI--T 232
            |.:||||.||.|:.|::..|.|.|.:|||.     |.|          |:|.   ||:|.||  .
 Frog   118 QNLGIQCVKKREVEDAIAHRIRTNNNPFNVPPEELKSD----------YDLNTVCLCFQVFIPDR 172

  Fly   233 VGNSKVPLDPIVSSPIYG----KSSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETD 293
            .....|||..:||.|||.    .::||.|.|:...:.:..|||||.:||:|:.|:||||.|.
 Frog   173 AAGQVVPLPFVVSQPIYDNRAPNTAELKICRVNRNSGSCMGGDEIFLLCDKVQKEDIEVLFV--- 234

  Fly   294 KDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYP- 357
               ...|.|...|...||.:|:||.|:||.:.:|:|.|||.|:::|.||||...|.|:.|:|.|
 Frog   235 ---LGNWEARGIFSQADVHRQVAIVFRTPAFHDTKIRQSVKVQMQLRRPSDKEVSEPMEFQYLPD 296

  Fly   358 --NPGTVTFARLQRKLKRRQELDVFQQILS---LDSET-TATKYSCPPMDLEEDNNTVSSDDQQS 416
              :|..:       ..||::.||.|:..:.   ...|| |..:.:.|...:...:..:::..:.|
 Frog   297 EVDPHHI-------DEKRKRTLDSFKHYVKNPFAGGETRTPRRIAVPNRIVPTKSEPITASIRPS 354

  Fly   417 SGTLN------EFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDC 475
            ....|      .|.:.|.|:. .....|..:....:::::      ::....:.|   ||...|
 Frog   355 PSVPNPMVPSLSFSMPVLKVD-SVTSASTRLSTVNISDFS------NLGFSSQPP---PQSDPD- 408

  Fly   476 TQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERTDSLTVENGD-TQSLSNSTAQTAFT-- 537
                 .:|..|.:|.....  :|::.:......:|...|...:::|.| :|.||.|  ||:.|
 Frog   409 -----RIESFLNYPSFSGD--ANLDLVEMLPNDTESRCTSLSSIDNSDFSQLLSES--QTSGTLS 464

  Fly   538 ------------------NVSSLTANTTITNQLDEEAHGLLANG 563
                              :::.|.:|..|.:..:|....:|.||
 Frog   465 AGLQEPGTSQGTLMSYPDSIARLMSNRPIEDDGEERIDSVLMNG 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	79/187 (42%)
		RHD_dimer	256..358	CDD:465045	43/104 (41%)
rela	XP_012816239.2	RHD-n_RelA	23..192	CDD:143645	79/183 (43%)
		IPT_NFkappaB	199..295	CDD:238582	43/101 (43%)