Protein Alignment Dif and dl

DIOPT Version :10

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Alignment Length: 1081
• Identity: 415/1081 - (38%)
• Similarity: 558/1081 - (51%)
• Gaps: 202/1081 - (18%)

  Fly    20 NGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEPSARSGPHLRIVE 84
            ||.|.|.|.   ||.|        .||.:...:|:.     |.|.:.|:  ..:.|..|:::|.|
  Fly     7 NGAAPGQGP---AVDG--------QQSLNYNGLPAQ-----QQQQLAQS--TKNVRKKPYVKITE 53

  Fly    85 EPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSCVTSDEPFRQHPHW 149
            :|....:||||:||||:||||||:||:.| .||:||||:..|.|..::||||||.|.|:|.|||.
  Fly    54 QPAGKALRFRYECEGRSAGSIPGVNSTPE-NKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHN 117

  Fly   150 LVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRNIDPFNAKFDHKDQ 214
            ||.||   .||.|:...::..|..|.|...:||||.||.::..:|..||...:|||...|.|:.|
  Fly   118 LVGKE---GCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQ 179

  Fly   215 IDKINRYELRLCYQAFI---TVGNSKVPLDPIVSSPIYGKS--SELTITRLCSCAATANGGDEII 274
            ...|:...:|||:|.|:   ..|....||.|:||.||:.|.  |:|.|.|||||:||..|..:||
  Fly   180 PSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGNTQII 244

  Fly   275 MLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYRNTEITQSVNVELKL 339
            :||||:||:||.|||:| :|:|:..|.|..:||.|||.||.||.||||||...:||:...|.::|
  Fly   245 LLCEKVAKEDISVRFFE-EKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQL 308

  Fly   340 VRPSDGATSAPLPFEYYP-NPGTVTFARLQRKLKRRQELDVFQQILSLDSETTATKYSCPPMDLE 403
            .|||||.||..|||||.| :.|..||..|.|.|||:.:.|:|||||.||::......:...:||:
  Fly   309 RRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLD 373

  Fly   404 EDNNTVS-----------SDDQQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDN--- 454
            .....|.           .:.|||...| |.|.:|::.|..|. :|.:.:     :||...:
  Fly   374 TPKIDVQREIPSEMEFNHEESQQSEPAL-EQEQSVQQEQYTQE-QSLQQE-----QYTQEQSLQQ 431

  Fly   455 -------EPDMEIELEVP----QLLP------QLAD---DCTQTSTP------------------ 481
                   |.....:||.|    |.||      |..|   |.|....|
  Fly   432 EQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLR 496

  Fly   482 -----------------MEEILQHPQLQSRPLSNVETITEWMKSSEFER---TDSLTVENGDTQS 526
                             :|::....||:.|||:..:.|||||||||.|:   ..|.|.|.....|
  Fly   497 SEQEKEIDTIIDEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDS 561

  Fly   527 -LSNSTAQTAFTNVSSLTANTTITNQLDEEAHGLLANGSRRDTLENPAVKELPENEKEPEMVSAS 590
             |..|.|......:....|      :|||.......   :|||.:|..         :.|:....
  Fly   562 ALEISKADKTLDELLETVA------ELDEIYTDFKV---QRDTYKNTI---------QNELAGLQ 608

  Fly   591 AQASMDLDENFDETATYTSLQIAFNNPIDIGLPKESKQAAPIYPPTNPFGQLDDDELVVLTNPPA 655
            .:|.:.::::||:.||||||||||.||:.|  |.:.     |.|||.|..|...::.....:|
  Fly   609 GRAPLQVEDSFDDAATYTSLQIAFKNPVLI--PMDD-----IMPPTPPMSQCAPEDAHQHYDP-- 664

  Fly   656 PRIKVNAAQTPATPPASPPLPLPPRTPS------PVSDQRLPPLPPKPQR----NSQDLSAVSDS 710
              ::||   :.|..|.:|..|:||..|:      |..:.:|||||||..|    |:::.|..:::
  Fly   665 --VEVN---SQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANT 724

  Fly   711 ISVSRSRNGSLSSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQGFFSRFFSRRRSKTDDEES 775
            :....|...|..:.|..|:|    :.|:.:...||        |:.||||:.||||:||.|..:
  Fly   725 VQTKPSTGESPLNKRLPPAP----KNPNFNTLPRQ--------KKPGFFSKLFSRRKSKPDLAQ- 776

  Fly   776 LTPGGSPNKQLPGGSKATTPTGSREPSVAHFSLGDPNRSSTRSMQPLG----------------- 823
                |..|..:. .|||    .|||||:.||::.||.|:|.||.:...
  Fly   777 ----GQENSSIL-DSKA----NSREPSIGHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAK 832

  Fly   824 KSEGRNGKPVGRSSSSVSGKRPAHLDADVIHIPLKGGDSENSL---LRPESYSNASTLSYGRPLD 885
            |...:..||||||.|||||||||:|:|||:||||| |||.|||   .|.|.||.:||:|.|..||
  Fly   833 KPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLK-GDSVNSLPQQQRTEGYSQSSTISVGAGLD 896

  Fly   886 RKTLSTLQLADIPISDGNMELIAIADRQSIKNL---CEGAYGVVLDPSVDLSEAEHFALYTSKSP 947
            |:|.|.|||||||||:|.|||:|||||||:.||   .||.:.|.|||::||:||||||||||
  Fly   897 RRTASALQLADIPISEGGMELVAIADRQSLHNLVSSIEGHFNVQLDPNLDLTEAEHFALYTS--- 958

  Fly   948 EPPF--GGECGEGGAATGGVDTTDFLSADEIARRLAEANGL 986
            .||.  ..|..|..|....||..:.|:.||:|:|||.|||:
  Fly   959 IPPLAAASEFDETSAYYAPVDAGEILTPDEVAKRLAAANGI 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	80/176 (45%)
		RHD_dimer	256..358	CDD:465045	59/102 (58%)
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	80/176 (45%)
		IPT_NFkappaB	225..326	CDD:238582	59/101 (58%)