DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and Rela

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_954888.1	Gene:	Rela / 309165	RGDID:	727889	Length:	550	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	171/590 - (28%)
Similarity:	264/590 - (44%)	Gaps:	119/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVS 135
            ||:..|||::.|:|:|....:|||||||||:|||||| ..|::|.||.|||::..|.||..:.:|
  Rat    12 EPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPG-ERSTDTTKTHPTIKINGYTGPGTVRIS 75

  Fly   136 CVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERR 200
            .||.|.|.|.|||.||.|:    |:.|.|:.:|.|:......|.:||||.||.::..::.:|.:.
  Rat    76 LVTKDPPHRPHPHELVGKD----CRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQT 136

  Fly   201 NIDPFNAKFDHKDQIDKINRYEL---RLCYQAFITV---GNSKVPLDPIVSSPIYG----KSSEL 255
            |.:||....:     ::...|:|   |||:|  :||   ....:.|.|::|.||:.    .::||
  Rat   137 NNNPFQVPIE-----EQRGDYDLNAVRLCFQ--VTVRDPSGRPLRLTPVLSHPIFDNRAPNTAEL 194

  Fly   256 TITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFK 320
            .|.|:...:.:..|||||.:||:|:.|:||||.|....      |.|...|...||.:|:||.|:
  Rat   195 KICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPG------WEARGSFSQADVHRQVAIVFR 253

  Fly   321 TPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILS 385
            ||.|.:..:...|.|.::|.||||...|.|:.|:|.|:  |....|::.|.||..|  .|:.|:.
  Rat   254 TPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD--TDDRHRIEEKRKRTYE--TFKSIMK 314

  Fly   386 LDSETTATKYSCPPMDLEEDNNTVSSDDQ---------QSSGTLN--EFEIAVKKMQMRQRGESH 439
            .......|:...||..:...:...:|..:         .|..|:|  ||...|.
  Rat   315 KSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVL----------- 368

  Fly   440 EMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEILQH---------------P 489
                            |..:|..:...|.|..|....||..|...::..               |
  Rat   369 ----------------PPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPP 417

  Fly   490 QLQSRPL-----SNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTIT 549
            |..|.|:     :...|::|.:...:|:..:.|..      .|.|:|....||:::|:.
  Rat   418 QSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGA------LLGNNTDPGVFTDLASVD------ 470

  Fly   550 NQLDEEAHGLLANG-SRRDTLENPAVKELPE--------NEKEPEMVSASAQAS-----MDLDEN 600
               :.|...||..| :...:...|.:.|.||        :::.|:...|:...|     :..||:
  Rat   471 ---NSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDED 532

  Fly   601 FDETA 605
            |...|
  Rat   533 FSSIA 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	70/183 (38%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	39/101 (39%)
Rela	NP_954888.1	RHD-n_RelA	19..187	CDD:143645	70/179 (39%)
Rela	NP_954888.1	IPT_NFkappaB	194..290	CDD:238582	40/101 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351521
Domainoid	1	1.000	99	1.000	Domainoid score	I6882
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3583
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm9057
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.960