DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and Rel

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_008768670.2	Gene:	Rel / 305584	RGDID:	1311231	Length:	595	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	181/621 - (29%)
Similarity:	288/621 - (46%)	Gaps:	106/621 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 ARSG--PHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSC 136
            |.||  |::.|:|:|....:|||||||||:|||||| ..|::..:|:|:|::.||.|...:.::.
  Rat     2 ASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPG-ERSTDNNRTYPSIQIMNYYGKGKVRITL 65

  Fly   137 VTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRN 201
            ||.::|::.|||.||.|:    |:.|.|:.:..||.|.|..|.:||:|.||.|::::::.|....
  Rat    66 VTKNDPYKPHPHDLVGKD----CRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAG 126

  Fly   202 IDPFNAKFDHKDQIDKINRYELRLCYQAFI--TVGNSKVPLDPIVSSPIYG----KSSELTITRL 260
            |:|||........|:..:...:|||:|.|:  ..||....|.||||:|||.    .::||.|.|:
  Rat   127 INPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRV 191

  Fly   261 CSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYR 325
            .....:..|||||.:||:|:.||||||||...|      |.|...|...||.:|:||.|:||.|.
  Rat   192 NKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLND------WEAKGIFSQADVHRQVAIVFRTPPYC 250

  Fly   326 NTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSET 390
            .. |.:.|.|:::|.||||...|..:.|.|.|:....    ...|.|:::...:||::|. |.|.
  Rat   251 RA-IVEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDA----YGNKSKKQKTTLIFQKLLQ-DCEK 309

  Fly   391 TATKYSCP------PMD-------LEEDNN-----TVSSDDQQSSGTLNEFEIAVKKMQMRQRGE 437
            .......|      |::       :::::|     ||..:..:|||...:             .|
  Rat   310 RIIPSHFPEKTRAVPLESIGETRFIKKESNLFSHGTVLPETPRSSGVPGQ-------------AE 361

  Fly   438 SHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEILQHP----QLQSRPL-- 496
            .:....|:::....:.           |..:|.:.......| |:.....||    .|.|.|.
  Rat   362 PYYSSSGSISNALPHH-----------PSAMPSMVHQPASWS-PVTHPTSHPGSTNTLSSFPAGQ 414

  Fly   497 --SNVETITEWMKSSEFE----------RTDSLTVENGDTQSLSNSTAQTAFTNVSSLT-----A 544
              ||.:.:..::..:...          .||:|.  ..:|.|:| .|...:.::|:.||     .
  Rat   415 LSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLA--RMETPSMS-PTDLYSISDVNMLTNRPVSV 476

  Fly   545 NTTITNQLDEEAHGLLANGSRRDTLENPAVKELPENEKEPEMVSASAQASMDLDENFDETATYTS 609
            .|:.|:.:.:..|..|.:.:    ||||:.....: .::|..:...:.|||.. .....::.:.|
  Rat   477 MTSSTDGMGDTDHPRLVSVN----LENPSCNSRLD-PRDPRQLHQMSTASMSA-AGTSSSSVFVS 535

  Fly   610 LQIAFNNP----IDIGLPKESKQAAPIYPPTNPFGQ 641
            ....||.|    ||.||..|...|...:.|.  |.|
  Rat   536 QSDTFNRPHFSCIDNGLTNEPGLANDAHHPN--FAQ 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	70/179 (39%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	42/101 (42%)
Rel	XP_008768670.2	RHD-n_c-Rel	8..179	CDD:143649	70/175 (40%)
Rel	XP_008768670.2	RHD_dimer	187..282	CDD:406564	42/101 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351525
Domainoid	1	1.000	99	1.000	Domainoid score	I6882
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3583
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm9057
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.000