Protein Alignment Dif and Rela

DIOPT Version :9

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: XP_006531757.1
• Gene: Rela / 19697
• MGIID: 103290
• Length: 556
• Species: Mus musculus
• Alignment Length: 587
• Identity: 169/587 - (28%)
• Similarity: 264/587 - (44%)
• Gaps: 114/587 - (19%)

  Fly    71 EPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVS 135
            ||:..|||::.|:|:|....:|||||||||:|||||| ..|::|.||.|||::..|.||..:.:|
Mouse    19 EPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPG-ERSTDTTKTHPTIKINGYTGPGTVRIS 82

  Fly   136 CVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERR 200
            .||.|.|.|.|||.||.|:    |:.|.|:..|.|:......|.:||||.||.::..::.:|.:.
Mouse    83 LVTKDPPHRPHPHELVGKD----CRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQT 143

  Fly   201 NIDPFNAKFDHKDQIDKINRYEL---RLCYQAFITV---GNSKVPLDPIVSSPIYG----KSSEL 255
            |.:||:...:     ::...|:|   |||:|  :||   ....:.|.|::|.||:.    .::||
Mouse   144 NNNPFHVPIE-----EQRGDYDLNAVRLCFQ--VTVRDPAGRPLLLTPVLSHPIFDNRAPNTAEL 201

  Fly   256 TITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFK 320
            .|.|:...:.:..|||||.:||:|:.|:||||.|....      |.|...|...||.:|:||.|:
Mouse   202 KICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPG------WEARGSFSQADVHRQVAIVFR 260

  Fly   321 TPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILS 385
            ||.|.:..:...|.|.::|.||||...|.|:.|:|.|:  |....|::.|.||..|  .|:.|:.
Mouse   261 TPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD--TDDRHRIEEKRKRTYE--TFKSIMK 321

  Fly   386 LDSETTATKYSCPPMDL---EEDNNTVSSDDQQ------SSGTLNEFEIAVKKMQMRQRGESHEM 441
            .......|:...|...:   ..::.:|.....|      |..|:|..|.:...:
Mouse   322 KSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLL----------- 375

  Fly   442 DGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEILQ--------------HPQLQ 492
                          |..:|..:...|.|..|....||..|...::.              .||..
Mouse   376 --------------PSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSL 426

  Fly   493 SRPL-----SNVETITEWMKSSEFERTDSLTVENGDTQSLSNSTAQTAFTNVSSLTANTTITNQL 552
            |.|:     :...|::|.:...:|:..:.|..      .|.|||....||:::|:.
Mouse   427 SAPVPKSTQAGEGTLSEALLHLQFDADEDLGA------LLGNSTDPGVFTDLASVD--------- 476

  Fly   553 DEEAHGLLANG-SRRDTLENPAVKELPE--------NEKEPE-----MVSASAQASMDLDENFDE 603
            :.|...||..| |...:...|.:.|.||        :::.|:     :.::.....:..||:|..
Mouse   477 NSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSS 541

  Fly   604 TA 605
            .|
Mouse   542 IA 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	70/183 (38%)
		RHD_dimer	256..358	CDD:292797	39/101 (39%)
Rela	XP_006531757.1	RHD-n_RelA	26..194	CDD:143645	70/179 (39%)
		IPT_NFkappaB	201..297	CDD:238582	40/101 (40%)
		PHA03247	<262..528	CDD:223021	63/309 (20%)
		DUF5364	<451..539	CDD:375130	20/102 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3721
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	1	1.000	-	-		FOG0002243
OrthoInspector	1	1.000	-	-		mtm8810
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.990