Protein Alignment Dif and Rel

DIOPT Version :10

• Sequence 1: NP_001162998.1
• Gene: Dif / 35045
• FlyBaseID: FBgn0011274
• Length: 987
• Species: Drosophila melanogaster
• Sequence 2: NP_033070.2
• Gene: Rel / 19696
• MGIID: 97897
• Length: 588
• Species: Mus musculus
• Alignment Length: 623
• Identity: 174/623 - (27%)
• Similarity: 280/623 - (44%)
• Gaps: 120/623 - (19%)

  Fly    74 ARSG--PHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTIEVCNYDGPVIIVVSC 136
            |.||  |::.|:|:|....:|||||||||:|||||| ..|::..:|:|::::.||.|...|.::.
Mouse     2 ASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPG-ERSTDNNRTYPSVQIMNYYGKGKIRITL 65

  Fly   137 VTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPEERRLVLQKVGIQCAKKLEMRDSLVERERRN 201
            ||.::|::.|||.||.|:    |:.|.|:.:..||.|.|..|.:||:|.||.|::::::.|....
Mouse    66 VTKNDPYKPHPHDLVGKD----CRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAG 126

  Fly   202 IDPFNAKFDHKDQIDKINRYELRLCYQAFI--TVGNSKVPLDPIVSSPIYG----KSSELTITRL 260
            |:|||........|:..:...:|||:|.|:  ..||....|.||||:|||.    .::||.|.|:
Mouse   127 INPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRV 191

  Fly   261 CSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQPTDVFKQMAIAFKTPRYR 325
            .....:..|||||.:||:|:.||||||||...|      |.|...|...||.:|:||.||||.|.
Mouse   192 NKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLND------WEARGVFSQADVHRQVAIVFKTPPYC 250

  Fly   326 NTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKRRQELDVFQQILSLDSET 390
            .. |.:.|.|:::|.||||...|..:.|.|.|:....    ...|.|:::...:||::|. |...
Mouse   251 KA-ILEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDA----YGNKSKKQKTTLIFQKLLQ-DCGH 309

  Fly   391 TATKYSCPPMD-------LEEDNN-----TVSSDDQQSSG------------------------- 418
            ...|....|:.       :::::|     ||..:..:|||
Mouse   310 FTEKPRTAPLGSTGEGRFIKKESNLFSHGTVLPEMPRSSGVPGQAEPYYSSCGSISSGLPHHPPA 374

  Fly   419 -------------------------TLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDN---E 455
                                     ||:.|....  :....:|....::|..|::.:.:::   .
Mouse   375 IPSVAHQPTSWPPVTHPTSHPVSTNTLSTFSAGT--LSSNSQGILPFLEGPGVSDLSASNSCLYN 437

  Fly   456 PDMEIELEVPQLLPQLADDCTQTSTPMEEILQHPQLQSRPLSNVETITEWMKSSEFERTDSLTVE 520
            ||....:|.|.:.|          |.:..|.....|.:||||.:...|:.|..::..|..|:.:|
Mouse   438 PDDLARMETPSMSP----------TDLYSISDVNMLSTRPLSVMAPSTDGMGDTDNPRLVSINLE 492

  Fly   521 N---------GDTQSLSNSTAQTAFTNVSSLTANTTITNQLDEEAHGLLANGSRRDTLENPAVKE 576
            |         .|.:.|...:..:.....||.:...:.::..|......:.||    .:..|.
Mouse   493 NPSCNARLGPRDLRQLHQMSPASLSAGTSSSSVFVSQSDAFDRSNFSCVDNG----LMNEPG--- 550

  Fly   577 LPENEKEPEMVSASAQASMDL--DENFDETATYTSLQI 612
            |.::...|..|.:|..:|::.  .|...:..||...:|
Mouse   551 LSDDANNPTFVQSSHYSSVNTLQSEQLSDPFTYGFFKI 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	70/179 (39%)
		RHD_dimer	256..358	CDD:465045	43/101 (43%)
Rel	NP_033070.2	RHD-n_c-Rel	8..179	CDD:143649	70/175 (40%)
		IPT_NFkappaB	186..281	CDD:238582	44/101 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	291..296		1/4 (25%)
		Transcriptional transactivator	403..468		13/76 (17%)