DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and Nfkb2

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001170841.1	Gene:	Nfkb2 / 18034	MGIID:	1099800	Length:	900	Species:	Mus musculus

Alignment Length:	915	Identity:	226/915 - (24%)
Similarity:	338/915 - (36%)	Gaps:	250/915 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PEPSARSGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETG-KTFPTIEVCNYDGPVIIV 133
            |.|....||:|.|||:|.....||||.|||.:.|.:||  :|||.| ||:||:::|||:||..|.
Mouse    30 PAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPG--ASSEKGRKTYPTVKICNYEGPAKIE 92

  Fly   134 VSCVTSDEPFRQHPHWLVSKE--EADACKSGIYQKKLPPEERRL--------VLQKVGIQCAKKL 188
            |..||..:|.|.|.|.||.|:  |...|...:..|.:..:...|        .:.::.||..::.
Mouse    93 VDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQ 157

  Fly   189 EMR---DSLVERERRNIDPFNAKFDHKDQIDKINRYEL-RLCYQAFITV--GNSKVPLDPIVSSP 247
            .:|   ..|.|.|||.::. .||     ::.|:....: ||.:.||:..  |:..:||.|::|.|
Mouse   158 RLRSKPQGLTEAERRELEQ-EAK-----ELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQP 216

  Fly   248 IYGK----SSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEFQP 308
            |:..    :|.|.|:|:...|.:..||||:.:||:|:.||||||||||.|::|   |.|..:|.|
Mouse   217 IHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENG---WQAFGDFSP 278

  Fly   309 TDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNPGTVTFARLQRKLKR 373
            |||.||.||.|:||.|...:|.:.|.|.|:|.|...|..|....|.|||    :...:.:.:.||
Mouse   279 TDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYP----LVEDKEEVQRKR 339

  Fly   374 RQELDVFQQILSLDSETTATKYSCPPMDLEEDNNTVSSDDQQSSGTLNEF--EIAVKKMQ----- 431
            |:.|..|.|.....|.          |......:..........|:|..|  .:|....|
Mouse   340 RKALPTFSQPFGGGSH----------MGGGSGGSAGGYGGAGGGGSLGFFSSSLAYNPYQSGAAP 394

  Fly   432 ----------MRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQTSTPMEEIL 486
                      .:..|...:.|.|...|      ||  ....|.||..||..|...:.......:.
Mouse   395 MGCYPGGGGGAQMAGSRRDTDAGEGAE------EP--RTPPEAPQGEPQALDTLQRAREYNARLF 451

  Fly   487 QHPQLQSRPLSNVETITEWMKSSEFERTDSLTV-ENGDTQ------------------------- 525
            ...|..:|.|.:.....:.......:|...:.. |||||.
Mouse   452 GLAQRSARALLDYGVTADARALLAGQRHLLMAQDENGDTPLHLAIIHGQTGVIEQIAHVIYHAQY 516

  Fly   526 ----SLSNSTAQTAFTNVSSLTANTTITNQLDE--------EAHG-------LLANGSRRDTLEN 571
                :|:|...||.. :::.:|..|.:.:.|.:        :.||       |.|..:..:.|:.
Mouse   517 LGVINLTNHLHQTPL-HLAVITGQTRVVSFLLQVGADPTLLDRHGDSALHLALRAGAAAPELLQA 580

  Fly   572 ---------PAVKELPENE-----------KEPE----MVSASAQ----------ASMDLDENFD 602
                     |.:..:|:.|           :.||    :|...|:          .::.|....:
Mouse   581 LLRSGAHAVPQILHMPDFEGLYPVHLAVHARSPECLDLLVDCGAEVEAPERQGGRTALHLATEME 645

  Fly   603 ETATYTSL-----------QIAFNNPIDI----------------GLPKESKQAAPIYPPTNP-- 638
            |....|.|           ..|.|.|:.:                |....::...|:.|..:|
Mouse   646 ELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLPSPST 710

  Fly   639 FGQLDDDE---------------LVVLTNPPAPRIKVNAAQTPATPPASPPLPLPPRTPSPVSDQ 688
            .|...|.|               |.:..:.....:.:||||....||.:||.|..|..  .:.|.
Mouse   711 SGSDSDSEGPERDTQRNFRGHTPLDLTCSTKVKTLLLNAAQNTTEPPLAPPSPAGPGL--SLGDA 773

  Fly   689 RLPPLP-----PKPQRNSQDLSAVSDSISVSRSRNGSLS---SNRTTPSPI-------------- 731
            .|..|.     |:.|.:..:|:          .|.|..|   :.|.||||.
Mouse   774 ALQNLEQLLDGPEAQGSWAELA----------ERLGLRSLVDTYRKTPSPSGSLLRSYKLAGGDL 828

  Fly   732 --IIMRTPD----------QSPTKRQPTPSASPKKRQGFFSRFFSRRRSKTDDEESLTPGGSPNK 784
              ::....|          :.|..|...||.:..|....:.     .:|...:.|.|.|...|
Mouse   829 VGLLEALSDMGLHEGVRLLKGPETRDKLPSTAEVKEDSAYG-----SQSVEQEAEKLCPPPEP-- 886

  Fly   785 QLPGG 789
              |||
Mouse   887 --PGG 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	66/194 (34%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	48/101 (48%)
Nfkb2	NP_001170841.1	RHD-n_NFkB2	38..221	CDD:143650	66/190 (35%)
		IPT_NFkappaB	228..327	CDD:238582	48/101 (48%)
		Nuclear localization signal. /evidence=ECO:0000255	337..341		2/3 (67%)
		GRR	346..377		5/40 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..434		9/38 (24%)
		PHA03095	459..>705	CDD:222980	36/246 (15%)
		ANK repeat	487..524	CDD:293786	5/36 (14%)
		ANK 1	487..516		4/28 (14%)
		ANK repeat	526..557	CDD:293786	5/31 (16%)
		ANK 2	526..555		5/29 (17%)
		ANK 3	559..590		5/30 (17%)
		ANK repeat	559..586	CDD:293786	5/26 (19%)
		ANK repeat	599..630	CDD:293786	5/30 (17%)
		ANK 4	599..628		5/28 (18%)
		ANK repeat	633..665	CDD:293786	4/31 (13%)
		ANK 5	633..663		4/29 (14%)
		ANK repeat	667..698	CDD:293786	4/30 (13%)
		ANK 6	667..696		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..734		6/35 (17%)
		ANK 7	729..755		5/25 (20%)
		Death_NFkB2_p100	774..849	CDD:176776	14/84 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847941
Domainoid	1	1.000	115	1.000	Domainoid score	I6003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950