DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dif and LOC110438511

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_021326734.1	Gene:	LOC110438511 / 110438511	-ID:	-	Length:	499	Species:	Danio rerio

Alignment Length:	276	Identity:	58/276 - (21%)
Similarity:	95/276 - (34%)	Gaps:	69/276 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 SAVSDSISVSRSRNGSLSSNRTTPSPIIIMRTPDQSPTKRQPTPSASPKKRQGFFSRFFSRRRSK 769
            :|..||::.:.|....:::.|.:.....::......|.|....|            .||.....:
Zfish   280 NAYVDSVTYNGSTALHIAAGRGSTKLSALLMAAGADPHKENCEP------------LFFRDEEEE 332

  Fly   770 TDDEESLTPGGSPNKQLPGGSKATTPTGSREPSVAHFSLGDPNRSSTRSMQPLGKSEGRNGKPVG 834
            .:|:|...||.||.      |.|.:      |.|.:...|:..:.||..:.|.|..:.
Zfish   333 DEDDEGFIPGSSPL------SLAVS------PEVYNILNGEEYQPSTIVVPPQGDMQS------- 378

  Fly   835 RSSSSVSGKRPAHLD---------ADVIHIPLKGGDSENSLLRPESYSNASTLSYGRPLDRKTLS 890
             .||||.....:.||         |||:.:.:.     ||..|      .|:...|:.||...:|
Zfish   379 -LSSSVKQDLCSALDGPAGGWETLADVLGLGIL-----NSAFR------LSSCPAGKLLDSYEVS 431

  Fly   891 ---TLQLADIPISDGNMELIAIADRQSIKNLCEGAYGVVLDPSVDLSEAEHFALYTSKSPEPPFG 952
               .|:|.:.....||...:.:..    .::||....|...|.:  :.|.......:..||
Zfish   432 GGTVLELLEGLKRVGNCSAVTLLQ----NSVCEEPKSVHNTPPI--TGAGVCKALQALGPE---- 486

  Fly   953 GECGEGGAATGGVDTT 968
                |.|....||:|:
Zfish   487 ----ESGVCDSGVETS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797
LOC110438511	XP_021326734.1	Ank_2	88..183	CDD:315466
		ANK repeat	113..150	CDD:293786
		ANK	147..276	CDD:238125
		ANK repeat	152..183	CDD:293786
		ANK repeat	225..252	CDD:293786
		ANK repeat	255..287	CDD:293786	3/6 (50%)
		Ank_5	258..>316	CDD:330893	5/35 (14%)
		ANK repeat	289..320	CDD:293786	4/30 (13%)
		DD	383..455	CDD:326335	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010