DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dif and Relb

DIOPT Version :9

Sequence 1:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_008757276.1	Gene:	Relb / 100360982	RGDID:	2321078	Length:	559	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	165/608 - (27%)
Similarity:	247/608 - (40%)	Gaps:	139/608 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEP 72
            |..|||:..::.||....|                 :|.:.:|.:....|..|.:..:....|.|
  Rat    35 DELEIIDEYIKENGFGLDG-----------------AQLSEMPRLVPRGPASLSSVTLGPAAPPP 82

  Fly    73 SAR----------------SGPHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTI 121
            .|.                ..|:|.|.|:|....:||||:||||:||||.| .||:|..||.|.|
  Rat    83 PATPPWNCTLGRLVSPGPCPRPYLVITEQPKQRGMRFRYECEGRSAGSILG-ESSTEASKTLPAI 146

  Fly   122 EVCNYDG--PVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPE-ERRLVLQKVGIQ 183
            |:.:..|  .|.:....|..|.|.|.|||.||.|:    |..|:.:.:|.|. ..|.....:|||
  Rat   147 ELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKD----CTDGVCRVRLRPHVSPRHSFNNLGIQ 207

  Fly   184 CAKKLEMRDSLVERERRNIDPFNAKF--DHKDQIDKINRYELRLCYQAFITVGNSKV-PLDPIVS 245
            |.:|.|:..::..:.:..|||:||..  :|::    ::...:|:|:||........: .:|||:|
  Rat   208 CVRKKEIEAAIERKIQLGIDPYNAGSLKNHQE----VDMNVVRICFQASYRDQQGHLHRMDPILS 268

  Fly   246 SPIYGK----SSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEF 306
            .|:|.|    :|||.|.|:...:....||:|:.:||:|:.|:||.|.|      ...:|...|:|
  Rat   269 EPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVF------STASWEGRADF 327

  Fly   307 QPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNP----GTVTFARL 367
            ...||.:|:||.||||.|.:.||::.|.|.:.|.|.:||..|.||||.|.|..    |.
  Rat   328 SQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGV------ 386

  Fly   368 QRKLKRRQELDVFQQILSLDSETTATK-------------------YSCPPMDLEEDNNTVSSDD 413
             .|.::|...||..::.|.|.....:|                   ...||..|:      |:|.
  Rat   387 -DKKRKRGLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQ------SADT 444

  Fly   414 QQSSGTLNEFEIAVKKMQMRQRGESHEMDGGTVTEYTDNDNEPDMEIELEVPQLLPQLADDCTQT 478
            ....||       :....:...|....:|.|    :..:.:.|.:...|::....|.||......
  Rat   445 DFFPGT-------ISLPGLEPPGGPDLLDDG----FAYDPSAPTLFTMLDLLPPAPPLASAVVGN 498

  Fly   479 STPMEEILQHPQLQSRPLSNVETITEWMKSSEFERTDSLTVEN-GDTQSLSNSTAQTAFTNVSSL 542
            ......:::.|  ...|||                .||..... ||             ...:||
  Rat   499 GGAGATVVESP--GPEPLS----------------LDSFAAPGPGD-------------VGTASL 532

  Fly   543 TANTTITNQLDEEAH--GLLANG 563
            ..:....||..|.|.  |||:.|
  Rat   533 VGSNMFPNQYREAAFGGGLLSPG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	66/183 (36%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	40/101 (40%)
Relb	XP_008757276.1	RelB_leu_zip	1..76	CDD:292798	11/57 (19%)
		RHD-n_RelB	104..275	CDD:143646	65/179 (36%)
		RHD_dimer	283..379	CDD:292797	40/101 (40%)
		RelB_transactiv	382..559	CDD:292799	41/229 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9057
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.910