DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15141 and UBR7

DIOPT Version :9

Sequence 1:	NP_609837.1	Gene:	CG15141 / 35044	FlyBaseID:	FBgn0032635	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_786924.2	Gene:	UBR7 / 55148	HGNCID:	20344	Length:	425	Species:	Homo sapiens

Alignment Length:	427	Identity:	164/427 - (38%)
Similarity:	231/427 - (54%)	Gaps:	61/427 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QSTITMLDVLEQEKELEDEYAAVLGASDEKSCTYAKGPIGRQALYSCLTCCPEAREDLDKAAGVC 85
            :..::::||||:::|||:|..||||.||.:.|:|::|.:.|||||:|.||.||..|    .||:|
Human    15 EPVVSLVDVLEEDEELENEACAVLGGSDSEKCSYSQGSVKRQALYACSTCTPEGEE----PAGIC 75

  Fly    86 LACSYRCHEHHELVELYTKRNFRCDCPTQRLG--KCSLNPQVEGVQPRNVGNLYNQNFQGLYCKC 148
            |||||.||..|:|.||||||||||||...:..  :|.|.|....|   |.||.||.||.||||.|
Human    76 LACSYECHGSHKLFELYTKRNFRCDCGNSKFKNLECKLLPDKAKV---NSGNKYNDNFFGLYCIC 137

  Fly   149 KRPYPDPDRTVEEVMLQCAICEDWFHLPHMKA--PGASDKWLDVCSEMICDGCMDAKPFLKDYT- 210
            |||||||:..:.:.|:||.:||||||..|:.|  |.:.|     ..||:|..||....||..|.
Human   138 KRPYPDPEDEIPDEMIQCVVCEDWFHGRHLGAIPPESGD-----FQEMVCQACMKRCSFLWAYAA 197

  Fly   211 -------------------GLALQPVL-------EDA--KEDKPEA---DDSQLKNELDRSIC-- 242
                               |:..|.|:       :|:  |||.||.   |..::|.|.:...|
Human   198 QLAVTKISTEDDGLVRNIDGIGDQEVIKPENGEHQDSTLKEDVPEQGKDDVREVKVEQNSEPCAG 262

  Fly   243 -----DIMKVPEGESQPDEGEPSQKRAKLDDCRRPKPTKEHQGAAFWTNDWRKSLCQCSECLSLY 302
                 |:..|.:.||...|   |:...||.:.:..:..|: ..|.:|..:||..||.|.:|:.:|
Human   263 SSSESDLQTVFKNESLNAE---SKSGCKLQELKAKQLIKK-DTATYWPLNWRSKLCTCQDCMKMY 323

  Fly   303 KELAVEFLLDVEDSAKTYEERGMKRAEENSSYEQGIRALASIDRTQQIDAITEYNRMKDKLKEYL 367
            .:|.|.||.|..|:...||.:| |.|:.....:..:..|:|::|.||::.|.|||.:|.:||:||
Human   324 GDLDVLFLTDEYDTVLAYENKG-KIAQATDRSDPLMDTLSSMNRVQQVELICEYNDLKTELKDYL 387

  Fly   368 QAFAASKKVVTEEDINRFFAGMRNENNANL-GQPYFC 403
            :.||....||..|||.:||...:::....: |..|:|
Human   388 KRFADEGTVVKREDIQQFFEEFQSKKRRRVDGMQYYC 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15141	NP_609837.1	zf-UBR	62..122	CDD:280386	35/61 (57%)
CG15141	NP_609837.1	PHD_UBR7	145..199	CDD:277017	26/55 (47%)
UBR7	NP_786924.2	zf-UBR	46..113	CDD:280386	39/70 (56%)
		PHD_UBR7	134..185	CDD:277017	26/55 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..246		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151378
Domainoid	1	1.000	165	1.000	Domainoid score	I3933
eggNOG	1	0.900	-	-		E1_KOG2752
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11998
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2969
Isobase	1	0.950	-	0	Normalized mean entropy	S5277
OMA	1	1.010	-	-		QHG55347
OrthoDB	1	1.010	-	-		D1428122at2759
OrthoFinder	1	1.000	-	-		FOG0004989
OrthoInspector	1	1.000	-	-		oto90982
orthoMCL	1	0.900	-	-		OOG6_103861
Panther	1	1.100	-	-	LDO	PTHR13513
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720