DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15141 and mlo2

DIOPT Version :9

Sequence 1:	NP_609837.1	Gene:	CG15141 / 35044	FlyBaseID:	FBgn0032635	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_595478.1	Gene:	mlo2 / 2540600	PomBaseID:	SPBC4.05	Length:	329	Species:	Schizosaccharomyces pombe

Alignment Length:	392	Identity:	120/392 - (30%)
Similarity:	173/392 - (44%)	Gaps:	110/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ITMLDVLEQEKELEDEYAAVLGASDEKSCTYAKGPIGRQALYSCLTCCPEAREDLDKAAG----V 84
            :|:...:||::|||.|...||..|.: :|||:.|.: :|.||:||||        .||:|    |
pombe     8 LTVKQYVEQQRELEREAREVLPYSFD-TCTYSMGYL-KQPLYACLTC--------QKASGSLNAV 62

  Fly    85 CLACSYRCHEHHELVELYTKRNFRCDCPTQRLGK--CSLNPQVEGVQPRNVGNLYNQNFQGLYCK 147
            |.:||..||..|:||:|:.||:|||||.|.|...  |:|...|:.....|.   ||.||:|.:|.
pombe    63 CYSCSISCHADHDLVDLFNKRHFRCDCGTTRTHSIPCNLRKSVDECGSEND---YNHNFEGRFCI 124

  Fly   148 CKRPYPDPDRTVEEVMLQCAICEDWFHLPHMK-------APGASD-KWLDVCSEMICDGCMDAKP 204
            |...| :|: |.|..|.||.:||||||...::       .|.|.. :|| ||||     |.:.
pombe   125 CDTVY-NPE-TEEGTMFQCILCEDWFHEKCLQKTNKGIAIPDAETFEWL-VCSE-----CSEK-- 179

  Fly   205 FLKDYTGLALQPVLEDAKEDKPEADDSQLKNELDRSICDIMKVPEGESQPDEGEPSQKRAKLDDC 269
             .:|:                       |.|:...||....:.|
pombe   180 -YRDH-----------------------LLNQKHESIAGTERAP--------------------- 199

  Fly   270 RRPKPTKEHQGAAFWTNDWRKSLCQCSECLSLYKELAVEFLL-------DVEDSAKTYEERGMKR 327
                        .|.:.::|::||.|..|:|| :.|.:..|:       ..|||.....|.....
pombe   200 ------------LFLSENFRENLCPCESCISL-RNLEMPMLVAEEPIYEPPEDSEDGISEMNEDP 251

  Fly   328 AEENSSYEQGI--------RALASIDRTQQIDAITEYNRMKDKLKEYLQAFAASKKVVTEEDINR 384
            :|.....||.|        |.|..:.|.|..:::..|||:|.:|.::|..||...:|||:|||:.
pombe   252 SESGEMIEQVISSTMNDVLRILDRLPRVQANESVYAYNRLKSELTDFLTPFARENRVVTKEDISN 316

  Fly   385 FF 386
            ||
pombe   317 FF 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15141	NP_609837.1	zf-UBR	62..122	CDD:280386	30/65 (46%)
CG15141	NP_609837.1	PHD_UBR7	145..199	CDD:277017	23/61 (38%)
mlo2	NP_595478.1	zf-UBR	33..103	CDD:302988	35/79 (44%)
mlo2	NP_595478.1	PHD_UBR7	122..176	CDD:277017	23/61 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I2798
eggNOG	1	0.900	-	-		E1_KOG2752
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I1346
OMA	1	1.010	-	-		QHG55347
OrthoFinder	1	1.000	-	-		FOG0004989
OrthoInspector	1	1.000	-	-		oto101772
orthoMCL	1	0.900	-	-		OOG6_103861
Panther	1	1.100	-	-	LDO	PTHR13513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R723
SonicParanoid	1	1.000	-	-		X3524
TreeFam	1	0.960	-	-
	13	12.860