DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and CEP350

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_011508493.1	Gene:	CEP350 / 9857	HGNCID:	24238	Length:	3189	Species:	Homo sapiens

Alignment Length:	2157	Identity:	417/2157 - (19%)
Similarity:	789/2157 - (36%)	Gaps:	627/2157 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRP 74
            |||...|...||.|..|.:...      ..:.:|.| ||...:.|.::..|:..          |
Human  1087 GTSTSRPLNATATPLSGVSYED------DFVSSPGT-GTSTEKKSTLEPHSTLS----------P 1134

  Fly    75 CCNHTTPKSG--PPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPG 137
            ..:|:..||.  |...:.||.......:.:|..|:.:..........||        ||.
Human  1135 QEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTE--------WLD----- 1186

  Fly   138 QIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRL----------TRLTTY 192
              :|.|:..       ..:|||...:. |...||       |.|..|:|          |..|..
Human  1187 --SFTGNVQ-------NSLLDEEKAER-GSHQGK-------KSGTSSKLSVKDFEQTLDTDSTLE 1234

  Fly   193 PLAG------------AQTPTSPLAKSSPDRSR-TVSPTASIRS-SMLRSPGIGGKNGMAVGDRV 243
            .|:|            .:||||||:.||....: .|:.|:|.|| |.:..|.|
Human  1235 DLSGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTI------------ 1287

  Fly   244 IVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSL 308
               :||                              |.:..:.|:.....:.......||
Human  1288 ---TGF------------------------------KPNAPLTDLNPAASRTTTENMAPI----- 1314

  Fly   309 SPSSKKTRLSRTGSRESLTS-IGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDL 372
             |.||  |.|..|....:.: :..:|:|        ..:.:|......|:.|....:...|:..:
Human  1315 -PGSK--RFSPAGLHHRMAAELSYLNAI--------EESVRQLSDVERVRGISLAQQESVSLAQI 1368

  Fly   373 LREKQQHVE------KLMVERDL-----DREDAQNQALQL-----------QKNINEVIIFTDTM 415
            ::.:||..|      ||..|::.     ..|:.:|:|.|:           |:.:.||:
Human  1369 IKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVL------ 1427

  Fly   416 YAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTS---------TRPTIAAATAAA 471
                            :::..|:..||      :.::.:||..:         ||..|:.|..|:
Human  1428 ----------------QEATCKIAAQQ------SETARLTTDAARQICEMAELTRTHISDAVVAS 1470

  Fly   472 AAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQC 536
            .|..|.    |...|:.||....:|.:.:..  .|:|.  |..:.....|..||::.:|   ...
Human  1471 GAPLAI----LYDHQRQHLPDFVKQLRTRTE--TDRKS--PSVSLSQSKEGTLDSKHQK---YSA 1524

  Fly   537 SIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEK 601
            |.|.        .::|..||.  ||..|      |:..|.|.  .|.:||         .|..||
Human  1525 SYDS--------YSESSGYKN--HDRRS------SSGSSRQE--SPSVPS---------CKENEK 1562

  Fly   602 MTIQQKEVESRIAEQLE--EEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENL-RR 663
             .:..:::||.|.||::  .:..||      ::.:.:|..|     :.....|:::.|:|.| .|
Human  1563 -KLNGEKIESSIDEQVQTAADDSLR------SDSVPSLPDE-----KETGSCSVTQAGLELLASR 1615

  Fly   664 ELELLKEEN------EKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDEC 722
            :...|..:|      ...|.|...:|...:.|..:|.....|.|.:......::|..|.:..|..
Human  1616 DPPTLASQNAGITDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSD 1680

  Fly   723 EILQTEVRMRDEQIRELNQ------------QLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKS 775
            |....| :......:|||.            .::.|...:..::..::....:|||:::
Human  1681 EEASPE-KTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREK------ 1738

  Fly   776 TLLEKTEKELVQSKEQAAKTLNDKEQ-----------------LEKQISDLKQLAEQEKLVREMT 823
            .|.|||:.||...:.| .|.|.||.:                 |:::.:::|:|.|..|..|:..
Human  1739 ALKEKTKAELAWLEHQ-KKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKER 1802

  Fly   824 ENAINQIQLEKESIEQQLALKQNELEDF--QKKQSESEVHLQEIKAQNT-QKDFEL-------VE 878
            :..:.| |.|.|.|.|.....|.:|:..  .|..|.|:...::.||.:. ..|.|.       :.
Human  1803 QLILKQ-QEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISIS 1866

  Fly   879 SGES------LKKLQQQLEQKTLG------------------------HEKLQAAL-EELKKEKE 912
            |.|:      |||::.::::|...                        |.|.|..: .:|.:
Human  1867 SSETSSIMQKLKKMRSRMDEKHCSPVHYFFSVFTSHHWASLSVCFPNLHPKFQLYIYNQLVR--- 1928

  Fly   913 TIIKEKEQELQQLQSKSAES---ESALKVVQVQLEQLQQQAAASGEE---GSKTVAK-LHDEISQ 970
             .:.::||:|.|.:..:.|.   :..|...:.::.|:::||.|:.::   ..||..| |.|:.::
Human  1929 -FLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE 1992

  Fly   971 LKSQAEETQSELK-----STQSNL--EAKSKQLE------------------------AANGSLE 1004
            .|..|.|.:|.:.     :::|::  |..|..:|                        ..:..||
Human  1993 QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELE 2057

  Fly  1005 EEAKKSGHLLEQ----ITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE 1065
            .....|.|.|.:    ::|.:|..|..:.. ..||..::|.......::   |.::...:|:.::
Human  2058 SSTSPSKHSLPKSCTSVSKQESSKGSHRTG-GQCHLPIKSHQHCYSWSD---ESLSMTQSETTSD 2118

  Fly  1066 ASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDE-IATGHKELTSKADAWSQEMLQKEKE 1129
            .||::.:::.:.|    ||:..:|..:.|..:..|...| :......|..:.:::.:.:.:.|.|
Human  2119 QSDIEGRIRALKD----ELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAE 2179

  Fly  1130 LQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERL 1194
            |.   |.|:.|..::.::|......||...:.:..|....|....::|..|..::.:::.:.|.:
Human  2180 LS---QDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHV 2241

  Fly  1195 E--ITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANI---------SATNAELSTVLEVLQA 1248
            :  ::.:|....|:..|..|:::.:..:..|..|..:..:         |..:.|....|.:|:
Human  2242 DASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLK- 2305

  Fly  1249 EKSETNHIFELFEMEADMNSERLIEKVTGIKEELKE---THLQLDERQKKFEE-------LEEKL 1303
            |.:.|:.|.::.:.:...:|:         |.|:||   |.|:..:.:..|.:       |:..|
Human  2306 ELNATSRILDMSDGKVGESSK---------KSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVL 2361

  Fly  1304 KQAQQSE----QKLQQESQTSKEKLTEIQ-QSLQELQDSVKQKE-ELVQNLEEKVRESSSIIEAQ 1362
            :|...||    :.|..:|:..::.|..:. ::|.:.::.:|::: :...|....::....|.|.:
Human  2362 EQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQK 2426

  Fly  1363 NTKLNESNVQLENKTSCLKE---TQDQLLESQKKE--KQLQEEAAKLSGELQQVQEANGDIKD-- 1420
            |||  |.::.........||   ::|..:.|.|||  .:|.::..::| .|..:::.:...:|
Human  2427 NTK--EKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS-SLLSLRKDSQSCRDKP 2488

  Fly  1421 -----------SLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENE---------- 1464
                       |....||:.:.|.||..:..|.:.:.:....:....|:||:|..
Human  2489 QPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTE 2553

  Fly  1465 ------------------------GNLQ-------GE-SLA----VTEKLQQLEQANGELKEAL- 1492
                                    ||:|       || |.|    ...:|.:.|..|....:.:
Human  2554 SPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIA 2618

  Fly  1493 ---CQKENGL---------------------------------------KELQGKLDESNTVLE- 1514
               |::::|:                                       .:.:|..|....|.|
Human  2619 YFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEY 2683

  Fly  1515 SQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSL-------QQKQLL---L 1569
            ..:||...:.| :|.:..:.|:|:.||..: :.:|.:.:|:...|.|:       :.|.|:   .
Human  2684 FYEKSLPSVND-IEASVNRSRSLKIETDNV-QDISGVLEAHVHQQSSVDSQISSKENKDLISDAT 2746

  Fly  1570 EK----------GNEFDTQLAEYQKVIDEMDD---AASVK--SALLEQLQNRVAELETALRQAND 1619
            ||          .|.|..:|.:.|:..:|.|:   .||.|  :.||:.|.....:||..|
Human  2747 EKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQL----- 2806

  Fly  1620 AQKTAYLETKELRRQLESL-----------------ELEKSREVLSLKAQMNGASSRSGKGDEVE 1667
              |::..|.|:.::|||.:                 :|::.::....|.|:   |::...||:.:
Human  2807 --KSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQL---SNQELLGDDQK 2866

  Fly  1668 -------SLDIETSLAKIN--FLNSIIADMQQKNDALKAKVQTLETLPMDFTKPHA--FDALTKR 1721
                   |.::|.....|:  ||:|.:.|.       |.::.:.:..|    :|.:  |.|..:.
Human  2867 KVTPQDLSQNVEEQSPSISGCFLSSELEDE-------KEEISSPDMCP----RPESPVFGASGQE 2920

  Fly  1722 KPAPRLF-CDICDEFDQHDTEDCPIQGSEDQDYSTPSSE--SNNNEKERKLP---APRKY----C 1776
            :.|.||. .::..||.....:|   |...|:|:...||.  ..|..:|..:|   .|::.    |
Human  2921 ELAKRLAELELSREFLSALGDD---QDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPC 2982

  Fly  1777 DSCEVFGHDTSE 1788
            ::.....|...|
Human  2983 ETLLAVPHTAEE 2994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	23/109 (21%)
		CAP_GLY	125..189	CDD:396049	15/73 (21%)
		CAP_GLY	239..306	CDD:396049	6/66 (9%)
		SMC_prok_B	<546..912	CDD:274008	92/444 (21%)
		Smc	734..1591	CDD:224117	206/1124 (18%)
		SHE3	1502..1702	CDD:293683	55/251 (22%)
		CLIP1_ZNF	1773..1789	CDD:406934	3/20 (15%)
CEP350	XP_011508493.1	CAP_GLY	2572..2635	CDD:279625	12/62 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463666at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820