DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and PAC2

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_010922.1	Gene:	PAC2 / 856724	SGDID:	S000000809	Length:	518	Species:	Saccharomyces cerevisiae

Alignment Length:	605	Identity:	118/605 - (19%)
Similarity:	214/605 - (35%)	Gaps:	179/605 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 VGDRVIVSSGFGSRPGILRYLGETQFAPG-NWCGVELDEPS-GKNDGTVDDIRYFECK-PKYGVF 300
            :|||:.:...|.:    ::::|..:..|. ...|||.|:.| ||:.||:|||.||:.: |..|.|
Yeast     5 IGDRLKIGGYFCT----IKFIGVIKPWPSVKAYGVEWDDHSRGKHSGTIDDIHYFDVQIPNSGSF 65

  Fly   301 VPIAKVSLSPSSKKTRLSRTGSRESLTSI--GTMNSIATTATSRMR--------MNAQQRKSSTP 355
            :..:|:      |...:.|....|:|:..  |:.|:|...:....|        :||:.:.....
Yeast    66 LKESKI------KSPGVRRITFYEALSEKYGGSSNNINDLSIGNKRVEGLGFDELNARNKNYKKL 124

  Fly   356 VKPILATPKSQ----FSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMY 416
            .|  :|...|.    |..||   |..:.::..:..:|||      .:|.|..|||.:..|.:.:
Yeast   125 RK--IALRDSDVAILFQNQD---ELNRVIQNCVNVKDLD------LSLNLFTNINSLCEFIEPL- 177

  Fly   417 APLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQP 481
            ..|...:.|:....|....:|.....||   .||..|                      :|.
Yeast   178 KNLESLNISQNKLLSGWDNLKEYDLSHI---KTLRLS----------------------SCG--- 214

  Fly   482 LQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGD 546
               ....|:.:..:..:..|:.......|  ..|.|...|:          |:.|:::|....|:
Yeast   215 ---LSYKHIGKLLKSFRTLKMLDLSYNNL--TSAGIQNFEN----------EIPCTLEELNISGN 264

  Fly   547 EL-------------------NAQSQVYKEKIHDLE------------SKITKLVSATPSLQSIL 580
            .|                   |..|:.....|:.:|            |.|..|....|||::|
Yeast   265 NLISFPLFPKNLTLKGLNVSNNQISRAPSIAIYSVESLDITDNKFKERSLIDDLNKTFPSLKNI- 328

  Fly   581 PPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKD 645
              .|..::.........::|:.|..  ||.:|.           :.|..||..|..:::...::.
Yeast   329 --HLSGNEFNYNGNYINVEEQATFY--EVLARF-----------DRVMVLNGSICDVKTRREAEM 378

  Fly   646 EALEKFSLSECGIE-NLRRELELLKE----------ENEKQAQEAQA------------------ 681
            ..:.|...:|...: ||.|...|:|.          .||::.:::..
Yeast   379 FFVSKVMNNELSYDTNLPRWSSLIKSYEIDMSKLSFNNERETRQSLVLKIKIRAGKKPSSDLDYW 443

  Fly   682 ---EFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRE---LN 740
               .||.:.. |||...:|:.::.|:|...::.|.           :..|::.....|.:   :|
Yeast   444 VLPSFTVRYV-KSVICRKLNFDILNVKLFHENSEG-----------MINEIKYNFRPISDFNVVN 496

  Fly   741 QQLDEVTTQLN---VQKADS 757
            ..:..|::.:|   :||.:|
Yeast   497 GDIIHVSSPVNNKSIQKVNS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049	23/69 (33%)
		SMC_prok_B	<546..912	CDD:274008	48/281 (17%)
		Smc	734..1591	CDD:224117	7/30 (23%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
PAC2	NP_010922.1	CAP_GLY	5..72	CDD:214997	24/76 (32%)
		leucine-rich repeat	154..179	CDD:275380	9/31 (29%)
		LRR_RI	<175..350	CDD:423007	34/221 (15%)
		leucine-rich repeat	180..204	CDD:275380	4/23 (17%)
		leucine-rich repeat	205..229	CDD:275380	6/54 (11%)
		leucine-rich repeat	256..277	CDD:275380	3/20 (15%)
		leucine-rich repeat	278..298	CDD:275380	3/19 (16%)
		leucine-rich repeat	299..324	CDD:275380	4/24 (17%)
		Ubiquitin_like_fold	<445..502	CDD:421700	12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000