DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and NIP100

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_015151.1	Gene:	NIP100 / 855929	SGDID:	S000006095	Length:	868	Species:	Saccharomyces cerevisiae

Alignment Length:	1089	Identity:	219/1089 - (20%)
Similarity:	418/1089 - (38%)	Gaps:	308/1089 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 LRSPGIGGKNGM---AVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDD 287
            :|:.|:.....|   ::.|.|:|:    ...|.::::||||||.|.|.|:|||:|.|||||:.:.
Yeast     1 MRNAGVQVDTNMQKISLQDTVLVN----EMKGRVKFIGETQFAKGIWYGIELDKPLGKNDGSANG 61

  Fly   288 IRYFECKPK--------YGVFVPIAKVSLS----PSSKKTRLSRTGSRESLTSIGTMNSIATTAT 340
            ||||:...|        ||:|  ..|.:|.    ...:.:.|:...::|::.::........:..
Yeast    62 IRYFDIDLKKANSNGGYYGLF--CKKDTLQFYKPDDDEHSLLNGNAAQETIKNLQVKCESLASKL 124

  Fly   341 SRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNI 405
            :::::...:.|:|...   |:|.::      :|..|...::||:.|..::..:.:...    .|.
Yeast   125 NKIKIENHELKTSVEK---LSTNET------VLLSKISRLDKLVKELKVENGNMKTHL----DNF 176

  Fly   406 NEVIIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAA 470
            |.::..:|::.||    |..:                    .|.|..|
Yeast   177 NHLLDASDSVMAP----DLDK--------------------GTLLERS----------------- 200

  Fly   471 AAAAAACNRQPLQQQQQPHLHQ------KQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERK 529
                              ||.|      |....|..||    ::.|.....:::|..:.|.   |
Yeast   201 ------------------HLLQGLLDQTKLSYDKAMKV----QEDLLEENTQLLEENAVLS---K 240

  Fly   530 KTEELQCSIDEA-QFCGD---ELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGA 590
            |..:|...:.:. ...||   ::.|||     |..::..|:|.        .:||   |.|:..|
Yeast   241 KISDLGLQLQQTNNTIGDLALQIEAQS-----KSSNIVDKLTN--------DNIL---LTSNIKA 289

  Fly   591 LQEEIAKLQEKMTIQQKEVESRIA-EQLEEEQRLRENVKYLNEQIATLQSELVSKDEA----LEK 650
            |..|:.:||.|   ::.:...||. ||||:|.||         |::.|||.|.::.|.    :|:
Yeast   290 LNNELEELQAK---EKLDENLRITYEQLEQELRL---------QLSNLQSALENEKEIAGTYIEE 342

  Fly   651 FSLSECGIENLRRELELLKEENEKQAQEAQAE-FTRKLAEKSVEVLR---------LSSELQNLK 705
            .|..:..:|::..:.....:..|.:....|.| :..||.:|..::..         |||:||.|
Yeast   343 NSRLKATLESIEAKTSHKFQSLELKVNTLQEELYQNKLLKKFYQIYEPFAQPHLAALSSQLQYL- 406

  Fly   706 ATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQ--KADSSALDDMLRLQK 768
              ::.:|||...|.:..|            |..:.:.|..::..|::.  |.....|:..|:..|
Yeast   407 --AEVIESENFGKLENIE------------IHIILKVLSSISYALHIYTIKNTPDHLETTLQCFK 457

  Fly   769 EGTEEKSTLLEKTEKELVQSKEQAA----KTLNDKEQLEKQISDL-------------KQLA--- 813
            ......|..|.:..:....||::.|    :.|.|.:.|:|.::.:             |.||
Yeast   458 VNIAPISMWLSEFLQRKFSSKQETAFSICQFLEDNKFLDKDVTLILKILHPILETTVPKLLAFLR 522

  Fly   814 --------EQEKLVREMTENAINQI-QLEKESIEQQLALKQNELEDFQKKQSESEVHLQEI---- 865
                    :...|:..:.|.:::.| :::|...:::::.:.|.|..:    ...::.|..|
Yeast   523 TNSNFNDNDTLCLIGSLYERSLSLIARIDKLIGKEEISKQDNRLFLY----PSCDITLSSILTIL 583

  Fly   866 --KAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSK 928
              .|...::|::.:   .|||||:       :..:.:::.||.:     ||..|:..:    |:.
Yeast   584 FSDALFLRQDYKRI---SSLKKLE-------VFFQGIESLLENI-----TIFPEQPSQ----QTS 629

  Fly   929 SAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKS 993
            .:||:..:|                  ||:.:.:.|.|.::                :.|:..|
Yeast   630 DSESQCNIK------------------EGNFSNSLLSDRLN----------------EENIRLK- 659

  Fly   994 KQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKE 1058
                      |...:|...|.|..||:|..:|.          |:|.||.:.......:|..||.
Yeast   660 ----------EVLVQKENMLTELETKIKIIIGR----------DLERKTLEENIKTLKVELNNKN 704

  Fly  1059 YAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATG----HKELTSKADAW 1119
              |.....:::.:|:||....|...|:       .:..||.:..|.....    .:|...:.:..
Yeast   705 --EENCGKTEILNKLKEENFNLVNRLK-------NMELKLYQIKDNNTLNKIYLDREKVDRVNLV 760

  Fly  1120 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQ 1184
            |:.|..:|...:::::|.:.|.|.....:......::.|:|.|.:      ...|..:|:.....
Yeast   761 SEIMELRETIRRQIKEQKRVSIDFSWLDELPAVENKQPFKEHINH------SLDTLGIEMFNFVS 819

  Fly  1185 TT-IKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANI 1232
            |: |.||:....:...||.|:     .|...|:.||...:.|::.:.|:
Yeast   820 TSRILDLKLDQPLAEDELWHE-----RDHSYISYLKRKRKNIRLKSQNV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049	30/74 (41%)
		SMC_prok_B	<546..912	CDD:274008	88/420 (21%)
		Smc	734..1591	CDD:224117	98/541 (18%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
NIP100	NP_015151.1	NIP100	12..828	CDD:227569	208/1036 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I2622
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830