DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and PFI

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_565017.1	Gene:	PFI / 843485	AraportID:	AT1G71440	Length:	531	Species:	Arabidopsis thaliana

Alignment Length:	596	Identity:	118/596 - (19%)
Similarity:	216/596 - (36%)	Gaps:	162/596 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ANTEQFIIGQRVWL--GGTRPGQIAFIGDTHFAAGEWAGVVLDEP-NGKNDGCVSGKRYFQCEPK 179
            ::.|.|||||||..  ...|.|.:.::||....:|.|.||..|:. :||::|.|:|..||.
plant     5 SSNESFIIGQRVHSLNDSRRVGTVKYVGDVEGYSGTWIGVDWDQDGDGKHNGSVNGVFYFN---- 65

  Fly   180 RGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVI 244
                           ..:|:..|.:...:..|..|:     :::..||...|..|:   ..|.:.
plant    66 ---------------GRSQSSASFVRSQNLSRGITL-----LQALELRYRTISTKD---EEDEMY 107

  Fly   245 VSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLS 309
            |.|. |:|...::.||..:..         |:.|...:.|...:.|.... ..||...:.  |:.
plant   108 VLSA-GNRRVSIQLLGGDKIQ---------DKLSRFEELTSASLSYLGVS-SLGVSSDLG--SIL 159

  Fly   310 PSSKKTRLSRTGSR-----------ESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATP 363
            |:.|  .|..||:.           |.|.::.|:|....:.:|.::...|.:.....|   |...
plant   160 PNLK--LLDLTGNLISDWEEIGALCEQLPALTTLNLSCNSLSSDIKSLPQLKNIRVLV---LNNS 219

  Fly   364 KSQFSMQDLLREKQQHVEKL-----MVERDLDREDAQNQA------LQLQKNI----NEVIIFTD 413
            ...::..::||.....:|:|     |:........:.:||      |.|..|.    :||:..:.
plant   220 GLSWTQVEILRRSLPGIEELHLMGNMISTITSTSSSDDQAFNSLRLLNLDDNCISDWSEVLKLSQ 284

  Fly   414 TMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTR-----PTIAAATAAA-- 471
            .......|.::      :|.||:             ..|...|.:|.:     |:::.....|
plant   285 LPCLEQLYLNK------NKLSRI-------------FQSVNGTESSEKGSDPFPSLSCLLLGANN 330

  Fly   472 ----AAAAACNRQP----LQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNER 528
                |:..|.|..|    ::..:.| :....:...|:          |.|.||:.:::....:|.
plant   331 IGDLASVDALNGFPQLVDIRLSENP-ISDPVRGGVPR----------FVLVARLTKVQVLNGSEV 384

  Fly   529 KKTEELQCSIDEAQFCGDELNAQS--------QVYK-EKIHDLESK------------ITKLVSA 572
            :..|:....|...:....:||.:|        :.|: :|:|.:|.:            .:.|:|.
plant   385 RAREKKDSEIRYVRMVMSKLNDKSGEIELLHPRFYELKKLHGIEDERASAENSGPKNIASGLISI 449

  Fly   573 T-----------PSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLREN 626
            |           |.|...||       |::.....|:..:...:.|.::.|:.  |:||......
plant   450 TLKCVGPSMGEKPHLTKKLP-------GSITVGKLKILSENFFKLKSIKPRLF--LQEEGSPFPT 505

  Fly   627 VKYLNEQIATL 637
            .  |:::.|||
plant   506 A--LDDETATL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	118/596 (20%)
		CAP_GLY	125..189	CDD:396049	21/66 (32%)
		CAP_GLY	239..306	CDD:396049	13/66 (20%)
		SMC_prok_B	<546..912	CDD:274008	25/124 (20%)
		Smc	734..1591	CDD:224117
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
PFI	NP_565017.1	CAP_GLY	12..81	CDD:214997	23/87 (26%)
		leucine-rich repeat	136..161	CDD:275380	5/27 (19%)
		PPP1R42	157..384	CDD:411060	45/261 (17%)
		leucine-rich repeat	162..187	CDD:275380	6/26 (23%)
		leucine-rich repeat	188..210	CDD:275380	4/21 (19%)
		leucine-rich repeat	211..225	CDD:275380	2/16 (13%)
		leucine-rich repeat	236..262	CDD:275380	5/25 (20%)
		leucine-rich repeat	263..287	CDD:275380	5/23 (22%)
		leucine-rich repeat	288..320	CDD:275380	7/50 (14%)
		leucine-rich repeat	321..345	CDD:275380	4/23 (17%)
		Ubl_TBCE	446..528	CDD:340564	18/80 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000