DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLIP-190 and CLIP2

DIOPT Version :10

Sequence 1:NP_001368962.1 Gene:CLIP-190 / 35042 FlyBaseID:FBgn0020503 Length:1795 Species:Drosophila melanogaster
Sequence 2:NP_003379.4 Gene:CLIP2 / 7461 HGNCID:2586 Length:1046 Species:Homo sapiens


Alignment Length:1315 Identity:320/1315 - (24%)
Similarity:546/1315 - (41%) Gaps:382/1315 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 QPSKMKAPSSFG---------STGSV---------SKIGRPCCNHTT-PKSGP-----PPREATS 92
            :||.:|.|...|         ||||.         ||.|.|....:: |.|.|     |.:....
Human     3 KPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPK 67

  Fly    93 MSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVL 157
            .:...||.|.                   .|::|:|||:.|.:||.:.::|:|.||.|:||||||
Human    68 AAEVGDDFLG-------------------DFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVL 113

  Fly   158 DEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA----------------------GAQTP 200
            |:|.|||||.|.|.|||:|...:|||:|.::||..|.|                      |..||
Human   114 DDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATP 178

  Fly   201 TSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKN------------GMAVGDRVIVSSGFGSRP 253
                    |..||.:....|:.:|.:::....|.|            .:.:||||:|.   |::.
Human   179 --------PLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVG---GTKT 232

  Fly   254 GILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV------SLSPS- 311
            |::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||      |.||: 
Human   233 GVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK 297

  Fly   312 SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPILATPKSQFSMQ 370
            :|||:     :|......|.:||.:::|:|::...| .|.......||...:.|..|.    ::|
Human   298 AKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT----ALQ 358

  Fly   371 DLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSK 432
            :.|:|||||:|:|:.||||:|.:   |.:...:::|.|                           
Human   359 EALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI--------------------------- 396

  Fly   433 KSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQA 497
             :.:|...:|::                                           ....:|.|:|
Human   397 -ALLKAQHEQYV-------------------------------------------AEAEEKLQRA 417

  Fly   498 KPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDL 562
            : ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..|:|:...:|.:|
Human   418 R-LLVESVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGEL 473

  Fly   563 E-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES--------------- 611
            | |.:.:...|...|:.:....|.:  .|.:..:.:|:|::|:::.|:|.               
Human   474 EQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536

  Fly   612 -RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQ 675
             ..||.|...:||....|....:...|:.:.   ::||:.:          :.|::.|:..|||.
Human   537 PDAAEILRLRERLLSASKEHQRESGVLRDKY---EKALKAY----------QAEVDKLRAANEKY 588

  Fly   676 AQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRMRDEQIREL 739
            |||. |....|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....:.::|.||
Human   589 AQEV-AGLKDKVQQATSENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649

  Fly   740 NQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEK 804
            ...::.:..:..::..:..|..|:           .|.:...|||.::.|.|.|:          
Human   650 KAVMEGIKMEHQLELGNLQAKHDL-----------ETAMHVKEKEALREKLQEAQ---------- 693

  Fly   805 QISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQN 869
                 ::||..::..|         .|||.::.:.:|     ||::.|.::.::|:.:.|::   
Human   694 -----EELAGLQRHWR---------AQLEVQASQHRL-----ELQEAQDQRRDAELRVHELE--- 736

  Fly   870 TQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 931
             :.|.|.....::::.|::|:   |:|.|.:|:||.|..:.|           ||::.|:.|...
Human   737 -KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGK-----------QEVESLREKLLV 789

  Fly   932 SESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQL 996
            :|:.|:.|:............|.:...:|:               .|:..::..|..|..:.|::
Human   790 AENRLQAVEALCSSQHTHMIESNDISEETI---------------RTKETVEGLQDKLNKRDKEV 839

  Fly   997 EAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAE 1061
                                                   |.:.|:|:.|                
Human   840 ---------------------------------------TALTSQTEML---------------- 849

  Fly  1062 SRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK 1126
             ||:.|.|:.|.|.....:.|.|:.:|...:.|.|...|..|  |:|...|.      |||:|:|
Human   850 -RAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD--ASGQLVLI------SQELLRK 905

  Fly  1127 EKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG 1182
            |:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|....|. .||..
Human   906 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK-SLSDQ 969

  Fly  1183 TQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVA--NANISATNAELS 1240
            .:.::.|.....|:  ..||| :.|::|||.:.|     .::.|:||::..  .|.....:...:
Human   970 RRYSLIDRSSAPEL--LRLQH-QLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSAN 1031

  Fly  1241 TVLEVLQAEKSETNH 1255
            .:.:..:|:|.|..|
Human  1032 GIHQQDKAQKQEDKH 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIP-190NP_001368962.1 PHA03307 <2..>118 CDD:223039 20/89 (22%)
CAP_GLY 125..189 CDD:460154 35/63 (56%)
CAP_GLY 239..306 CDD:460154 40/66 (61%)
SMC_prok_B <546..912 CDD:274008 80/386 (21%)
SMC_prok_B 743..1596 CDD:274008 108/532 (20%)
COG4913 <1534..>1703 CDD:443941
CLIP1_ZNF 1726..1743 CDD:465212
CLIP1_ZNF 1773..1789 CDD:465212
CLIP2NP_003379.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71 17/67 (25%)
CAP_GLY 81..145 CDD:460154 35/63 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..162 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..215 2/19 (11%)
CAP_GLY 221..285 CDD:460154 40/66 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..339 7/25 (28%)
Smc <356..>943 CDD:440809 163/819 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1046 4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.