DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLIP-190 and CLIP1

DIOPT Version :9

Sequence 1:NP_001368962.1 Gene:CLIP-190 / 35042 FlyBaseID:FBgn0020503 Length:1795 Species:Drosophila melanogaster
Sequence 2:NP_001376220.1 Gene:CLIP1 / 6249 HGNCID:10461 Length:2148 Species:Homo sapiens


Alignment Length:2285 Identity:575/2285 - (25%)
Similarity:937/2285 - (41%) Gaps:682/2285 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 QPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVL 116
            :||.:|||:.....||.:.        .||.:...|.|.|.    |.:..||..|:.|....   
Human     5 KPSGLKAPTKILKPGSTAL--------KTPTAVVAPVEKTI----SSEKASSTPSSETQEEF--- 54

  Fly   117 TANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRG 181
               .:.|.:|:|||:.|.:||.|.|:|:|.||.|:|||:|||||.|||||.|:|.|||||||.:|
Human    55 ---VDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKG 116

  Fly   182 IFSRLTRLT-------------TYPLAGAQTP----TSPLAKSSPDRSRTV-------------- 215
            ||:|.::||             |.|.:.|.:|    |:.:..|||.....:              
Human   117 IFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSA 181

  Fly   216 -------SPTASIRSSMLRSPGI--GGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCG 271
                   :.|||...|.|...|.  .|:..:.:||||:|.   |::.|::|:||||.||.|.|||
Human   182 TPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVG---GTKAGVVRFLGETDFAKGEWCG 243

  Fly   272 VELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV------SLSPSSKKT----RLSRTGSRE-- 324
            ||||||.|||||.|...|||:|:||||:|.|:.||      |.:|:..|.    |:..|.|..  
Human   244 VELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLK 308

  Fly   325 ---SLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMV 385
               |.:|:.:|:|:|::.:|| .|.......||...:.|..|.    ::|:.|:|||||:|:|:.
Human   309 RSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTT----ALQEALKEKQQHIEQLLA 369

  Fly   386 ERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTL 450
            ||||:|.:.......:.:...|:.:..|                         ...||:.     
Human   370 ERDLERAEVAKATSHVGEIEQELALARD-------------------------GHDQHVL----- 404

  Fly   451 SSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKA 515
                                                  .|..|..|.: ..|...|::|      
Human   405 --------------------------------------ELEAKMDQLR-TMVEAADREK------ 424

  Fly   516 RIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSIL 580
              |||.:.|:.|::|.|:||..::|......:|...:...|.:|.:||..:...|.....|:..|
Human   425 --VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRL 487

  Fly   581 PPDLPSDDG----ALQEEIAKLQEKMTI----------------------QQKEVES--RIAEQL 617
            ..:.|:.|.    :|.:||:.||||:.:                      .|||:::  ...|:|
Human   488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 552

  Fly   618 -EEEQRLRENVKYLNEQ----IA----TLQSELVSKDEALEKFSLS---------------ECGI 658
             :|.:.|:..:::.|::    ||    .|::.:.|..:|:|:..:|               :..|
Human   553 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 617

  Fly   659 ENLR----RELELL--KEENEKQAQEAQAEFTR-------KLAEKSVEVLRL---SSELQNLKAT 707
            |.:|    .|:|.|  ::::|:.|...:.|..|       |..|.|:|.:|.   .:|.|:|...
Human   618 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 682

  Fly   708 SDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTE 772
            .|:|     ||..|.||...|:.:...:..|..:.:|..|:||   ||....|.|:..|:|..:|
Human   683 EDTL-----NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL---KATEEKLLDLDALRKASSE 739

  Fly   773 EKSTLLEKTEKELVQSKEQAAKTLNDKE-----QLEKQISDLKQLAEQEKLVREMTENAINQIQL 832
            .||.:     |:|.|..|.|.|.:...|     :..|..|..::|..:|..:..:.|| ::::..
Human   740 GKSEM-----KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN-LSEVSQ 798

  Fly   833 EKESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESG-----ESLKKLQQQL 890
            .||::|::|.:.:.:..:..::....:..:||.  |....::.|.::.|.     |:|..::.:.
Human   799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863

  Fly   891 EQKTLGHEKLQAALEELKKEKETIIKE-----------------KEQELQQLQSKSAES------ 932
            .:|....|:|..|.|:|:.:...|:|.                 ||:::::||.|..::      
Human   864 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 928

  Fly   933 -ESALKVVQVQLEQLQQQAAASGEEGSKTVAK-----------LHDEISQLKSQAEETQSELKST 985
             :.:::.:.|:.||.||:||...||..|.:.:           .|::..:||::.|...||.|:.
Human   929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 993

  Fly   986 QSN-LEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQA---ALSSCHTDVESKTKQLE 1046
            ... |:...|.|......|:...:::..||:::.:|:.:..:.::   .|:|...::|..:::|.
Human   994 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKSLTYLLTSAKKEIELMSEELR 1058

  Fly  1047 AANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAER----SSSSALHTKLSKFSDEIAT 1107
            ...:..:.:::|..:.:.|...|..|:.|:...: |.||.::    |.:..|:.:..||.:|...
Human  1059 GLKSEKQLLSQEGNDLKLENGSLLSKLVELEAKI-ALLQGDQQKLWSVNETLNLEKEKFLEEKQD 1122

  Fly  1108 GHK-----ELTSKADAWSQEMLQKE-----KEL-----------------QELRQQLQDSQDSQT 1145
            ..|     .|..:|.|..:|.|.||     :||                 |.|.::||.|:|:..
Human  1123 AEKYYEQEHLNKEALAVEREKLLKEINVVQEELLKINVENDSLQASKVSMQALIEELQLSKDTLI 1187

  Fly  1146 KLKAEGERKEK------------------------------SFEESIKNLQ------EEVTKAKT 1174
             .|.|.:::||                              |:||.:|:.:      |::|..|.
Human  1188 -AKTEKDQEEKDHLEDQIKKLITENFILAKDKDDIIQKLQRSYEELVKDQKALVQETEDLTAEKK 1251

  Fly  1175 ENLE-------------------------LSTGTQTTIKDLQERLEIT-NAELQHKEKMASEDAQ 1213
            ..||                         |...|...::| ||:|..: .|.||.|:.:.||.:.
Human  1252 SALEKLSNLDNTCIALKVERDNVLQNNRNLQLETDMLLQD-QEKLNASLQAALQVKQLLRSEASG 1315

  Fly  1214 KIADLKTLVEAIQVA---NANISATNAELSTVLEVLQAEKSETN-------HIFE---------L 1259
            ..|.|....:|::.|   ...:.|.|..|:.:||.::|.::.|:       |..|         |
Human  1316 LRAQLDDASKALRKAELETVQLEAANTSLTKLLEEIKARRAVTDSECIQLLHEKETLAASERRLL 1380

  Fly  1260 FEMEADMNSERLI-EKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK 1323
            .|.|..::..|:| ||:....||...|.:.|:|: ..:...|:::...:.:|.|.||:| ..|||
Human  1381 AEKEELLSENRIITEKLHKCLEEAAHTEMSLNEK-ITYLTSEKEMASQKMTELKKQQDS-LLKEK 1443

  Fly  1324 ----------LTEIQQSLQELQDSVKQKEE---------------------LVQNLEEKVRESSS 1357
                      |.|.:.|::.:.|..:|.::                     |.:.|:|:.:|:..
Human  1444 SSLETQNGALLAERENSIKAIGDLKRQCDQESANRSLVVQENMKLLGNIDALKKELQERKKENQE 1508

  Fly  1358 II-----------EAQNTKLNESNVQLENKTSCL---KETQDQLLESQKKEK--------QLQEE 1400
            ::           ||||||.|     ||.:.:.:   ||:.|..|.:...||        .||||
Human  1509 LVASKCDLSLMLKEAQNTKKN-----LEKEHTHILQAKESLDAQLNTCCSEKNILLRDGLNLQEE 1568

  Fly  1401 AAKLSGELQQVQEA------------------NGDIKDSLVKVE--------------------- 1426
            ..|||.|:|::|::                  |..:...:|.:|                     
Human  1569 CHKLSKEIQEMQQSLILEQEARAKESESSLYENNQLHGRMVLLEQEVEELRVCIEELQSEKFVLL 1633

  Fly  1427 --------ELVKVLEEK--LQAATSQLDAQQATNK-----------ELQEL-------------- 1456
                    ||.:::|||  |.|..:||.|...|.|           |||||              
Human  1634 QEKSKSEQELAEIIEEKELLTAEAAQLAAHIKTLKSDFAALSKSKAELQELHSCLTKILDDLQRN 1698

  Fly  1457 ---------------------------------------------------------------LV 1458
                                                                           |:
Human  1699 HEVTLAEKAQVMQDNQNLLAEKSEMMLEKDELLKEKETLAESYFILQKEISQLAKTNSHISANLL 1763

  Fly  1459 KSQENEGNLQGESLAVTEKLQQLE------------------------------------QANGE 1487
            :||.....|:.:...:|.|:::||                                    |.|.:
Human  1764 ESQNENRTLRKDKNKLTLKIRELETLQSFTAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1828

  Fly  1488 LKEAL-CQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLE-------QAQQKERTLQEETSKL 1544
            |:..| ..|||.||.:: :|::|..:|..:.:...|.:.::|       |..|:...||||..||
Human  1829 LQNELDTLKENNLKNVE-ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1892

  Fly  1545 AEQLSQLK------QANEELQKSLQQKQLLLEKGNE------FDTQLAEYQKVIDEMDDAASVKS 1597
            ||:|.:.:      |..|| ::|:...|||..|..|      .|.:.|..||.|.......:.|.
Human  1893 AEELGRSRDEVTSHQKLEE-ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1956

  Fly  1598 ALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGK 1662
            |.||:|:|.|    |.||..|.:.|:.:...:.|......|||:.....|.||......||.||.
Human  1957 AELEKLRNEV----TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 2017

  Fly  1663 GDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPM-----DFTKPHAFDALTKRK 1722
            .|.....|.....::|:||||:|.|:|:||..||.||:.:....:     |.....:.|...:.|
Human  2018 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 2082

  Fly  1723 PAPRLFCDICDEFDQHDTEDCPIQG--SEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHD 1785
            ..|||||||||.||.|||||||.|.  |||..:||  ...:..|:       |.||:.||:|||.
Human  2083 KKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHST--HHGSRGEE-------RPYCEICEMFGHW 2138

  Fly  1786 TSECADDETY 1795
            .:.|.||||:
Human  2139 ATNCNDDETF 2148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIP-190NP_001368962.1 PHA03307 <2..>118 CDD:223039 17/65 (26%)
CAP_GLY 125..189 CDD:396049 40/63 (63%)
CAP_GLY 239..306 CDD:396049 40/66 (61%)
SMC_prok_B <546..912 CDD:274008 102/445 (23%)
Smc 734..1591 CDD:224117 268/1266 (21%)
SHE3 1502..1702 CDD:293683 69/218 (32%)
CLIP1_ZNF 1773..1789 CDD:406934 8/15 (53%)
CLIP1NP_001376220.1 CAP_GLY 60..124 CDD:396049 40/63 (63%)
CAP_GLY 214..278 CDD:396049 40/66 (61%)
SbcC <335..835 CDD:223496 129/594 (22%)
Smc 612..1442 CDD:224117 190/848 (22%)
Smc 1176..1977 CDD:224117 175/815 (21%)
CLIP1_ZNF 2126..2142 CDD:406934 8/15 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141910
Domainoid 1 1.000 210 1.000 Domainoid score I2817
eggNOG 1 0.900 - - E1_COG5244
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1898
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1110101at2759
OrthoFinder 1 1.000 - - FOG0002895
OrthoInspector 1 1.000 - - otm40362
orthoMCL 1 0.900 - - OOG6_104816
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1398
SonicParanoid 1 1.000 - - X2251
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.730

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