DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLIP-190 and clip3

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_005157797.1	Gene:	clip3 / 562450	ZFINID:	ZDB-GENE-131127-193	Length:	539	Species:	Danio rerio

Alignment Length:	291	Identity:	102/291 - (35%)
Similarity:	148/291 - (50%)	Gaps:	43/291 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYF 174
            ||....|..::....:|.||.|..|:.|.:.|.|.|.||:|:|.|:.||||.|||||.|.|.|||
Zfish   269 DNIPGNLMLSSLGLKLGDRVVLDETKTGTLRFCGTTEFASGQWVGLELDEPEGKNDGSVGGIRYF 333

  Fly   175 QCEPKRGIFSRLTRLT----TYPLAGAQTPTSP----------LAKSSPDRSRTVSPTASIRSSM 225
            .|..|:|||:.::::|    ..|.:...||.:|          :.|...::.|..:|.....|.:
Zfish   334 ICSAKQGIFAPVSKITKAVEQTPSSVTSTPKTPRMDLSRVTGKIKKEKKEKDREKTPRKKSLSGV 398

  Fly   226 LRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRY 290
            ...|. |.|  :.|||:|:|:   |.:.||:|:.|:|.||||.|.||||::|:||:||:|..:||
Zfish   399 SLDPD-GVK--VEVGDQVLVA---GQKQGIVRFFGKTDFAPGYWFGVELEQPTGKHDGSVFGVRY 457

  Fly   291 FECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTP 355
            |.|.||||||.|       ||    |:.|.|..:.....||:    .....::.|:..:|..:..
Zfish   458 FHCLPKYGVFAP-------PS----RVQRIGGPKDPQGDGTL----VKKVHQVTMSQPKRNFNAV 507

  Fly   356 VKPILATPKSQFSMQDL--------LREKQQ 378
            ..|...|.:|..|.:.|        ||.:.|
Zfish   508 RSPKDITSESSISSRLLFCCWFPWMLRAEMQ 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	3/7 (43%)
		CAP_GLY	125..189	CDD:396049	33/63 (52%)
		CAP_GLY	239..306	CDD:396049	37/66 (56%)
		SMC_prok_B	<546..912	CDD:274008
		Smc	734..1591	CDD:224117
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
clip3	XP_005157797.1	ANK	100..222	CDD:238125
		ANK repeat	108..145	CDD:293786
		Ank_2	110..216	CDD:289560
		ANK repeat	147..178	CDD:293786
		ANK repeat	186..216	CDD:293786
		CAP_GLY	285..348	CDD:279625	33/62 (53%)
		CAP_GLY	410..473	CDD:279625	38/76 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463666at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920