DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and clip2

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_021332329.1	Gene:	clip2 / 556406	ZFINID:	ZDB-GENE-100727-3	Length:	1041	Species:	Danio rerio

Alignment Length:	1315	Identity:	337/1315 - (25%)
Similarity:	548/1315 - (41%)	Gaps:	380/1315 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIG 72
            |.|...|...|..|.|....||    ||..|    |||...|.|.......|||..|..|.||
Zfish     6 SSGLKIPGRGPKHASPVGRTTA----GPSTS----PATQKEGCPYKQTTPTPSSNASDKSSSK-- 60

  Fly    73 RPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPG 137
                                 :.|..|.::.                  .|::|:|||:.|.:||
Zfish    61 ---------------------ASEVGDEVAG------------------DFVVGERVWVNGVKPG 86

  Fly   138 QIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPL-------- 194
            .||::|:|.|:.|:||||||::..|||||.|:|.|||:|:..:|||:|.::||..|:
Zfish    87 VIAYLGETQFSPGQWAGVVLNDLVGKNDGSVNGVRYFECQALQGIFTRPSKLTRQPIGDGSDEQQ 151

  Fly   195 -------AGA--QTPTSPL--------AKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDR 242
                   |||  |....||        .|:..:....:|.:.|::.        ||:..:.||||
Zfish   152 NAQLQGGAGASGQRVVMPLREGMLNSSVKTGNESGSNMSDSGSVKK--------GGEKDLKVGDR 208

  Fly   243 VIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV- 306
            |:|.   |::.|::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||
Zfish   209 VLVG---GTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 270

  Fly   307 -----SLSPS-SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPI 359
                 |.||: :||::     :|......|.:||.:::|:|::...| .|.......||...:.|
Zfish   271 RIGFPSTSPAKAKKSKRMAMGVSSLAHSPSSSSISSVSSVASSVGGRPSRTGLLTETSSRYARKI 335

  Fly   360 LATPKSQFSMQDLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPY 421
            ..|.    ::|:.|:|||||:|:|:.||||:|.:   |.:...:::|.:
Zfish   336 SGTT----ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEL---------------- 380

  Fly   422 ADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQ 486
                    .:.|:|       |:...|...|::                             ||.
Zfish   381 --------AALKAR-------HLQYATETESNL-----------------------------QQV 401

  Fly   487 QPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQ 551
            :..|...|:          ||          :||.:.|:.|::|.|:||..::|......:|..|
Zfish   402 RAMLASTQK----------DK----------MELANQLEEEKRKVEDLQFRVEEESITKGDLETQ 446

  Fly   552 SQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEE--IAKLQEKMTIQQKEVE---- 610
            :::...:|..||..:....|....||..|...:.:   .::|:  :.:|:|::.:::.|||
Zfish   447 TKLEHARIRQLEQCLHLEKSKAERLQKELEEKMQT---TVEEKTRVMQLEEELALRKAEVEELQV 508

  Fly   611 ------SRIAEQLEE-EQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELL 668
                  |..|...|: |..:......|.||:.::..|  .::|:.:.....|..:...::|:|.|
Zfish   509 RFQRGSSGSATDAEDGEPGITSETLVLREQLLSVGRE--RREESSQLRERYEASLSTSQKEIERL 571

  Fly   669 KEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRD 733
            |...|:|.||. ::..::|.:.:.|.:.:   :.:.||..|:|                   :.|
Zfish   572 KAITERQGQEI-SDLKQRLQQATRENMEM---MDSWKAKLDAL-------------------VGD 613

  Fly   734 EQIRELNQQLDEVTT-----QLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQ-- 791
            .| |.|.:....:||     ::|..:.:.| |.:| |...||.:.:..|    |.|.:::|.:
Zfish   614 HQ-RALEELKASLTTDCGSGEINGGEGEGS-LPEM-RAALEGLKMEHQL----ELENLKAKHEID 671

  Fly   792 AAKTLNDKEQLEKQISDLK-QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQ 855
            ||....::|.|..::.:|: ||.:.|:..:...|...||..||.:.:.::|...:..:.|..|.|
Zfish   672 AAVMAKEREDLRSRLQELRDQLEDSEENWKIQVETKSNQHTLEIKEVSEKLQKAELRIVDLDKSQ 736

  Fly   856 SESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQ 920
            .|.|                         |:.|.|:::.:..||.....|.|:|.:    .:...
Zfish   737 EERE-------------------------KVNQLLKEQLMLAEKKMVDYEALQKAE----AQSRA 772

  Fly   921 ELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKST 985
            |:..||.|...:|:.|:.|:.. ...|........:.|       ||..:||...|||
Zfish   773 EILSLQEKLRVTENRLQAVEAD-HTTQDVNMIENNDNS-------DEKVKLKQNVEET------- 822

  Fly   986 QSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANA 1050
                                        ||::||.:.||       |:..|.|::...|:.|..
Zfish   823 ----------------------------LEKLTKREKEV-------STLTTQVDALKTQITALE- 851

  Fly  1051 ALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSK 1115
              |||  ...|..|:.     .:||.|     .|:||      |.|...|..|  |:|  :|.:
Zfish   852 --EKV--RLGEKTADG-----LIKEKT-----RLEAE------LETMTKKSHD--ASG--QLVN- 891

  Fly  1116 ADAWSQEMLQKEKELQELRQQLQDS--------QD-SQTKLKAEGERKEKSFEESIKNLQEEVTK 1171
               .|||:|:||:.|.|||..|.:|        :| |:...:||...||:..::.||.|:|::..
Zfish   892 ---ISQELLKKERSLNELRVLLLESPRHSAGVDRDLSREVHRAEWRMKEQKLQDDIKTLREKLLL 953

  Fly  1172 AKTENLELS---------TGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQV 1227
            ...|.|...         :.:.|.:..|::||..|...|::    |.|..|.:   ..||:|::.
Zfish   954 LGRERLSPDHRRYSMMDPSASDTEVARLRQRLLNTEDALRN----ALEHNQHV---DQLVQAMRT 1011

  Fly  1228 ------ANANISATN 1236
                  |:|:.::.|
Zfish  1012 RPDKNQAHASANSAN 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	25/109 (23%)
		CAP_GLY	125..189	CDD:396049	34/63 (54%)
		CAP_GLY	239..306	CDD:396049	41/66 (62%)
		SMC_prok_B	<546..912	CDD:274008	83/386 (22%)
		Smc	734..1591	CDD:224117	127/535 (24%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
clip2	XP_021332329.1	CAP_GLY	74..138	CDD:307465	34/63 (54%)
		CAP_GLY	205..269	CDD:307465	41/66 (62%)
		SMC_N	<341..994	CDD:330553	194/875 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2025
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1239
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110101at2759
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm24265
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	1	1.100	-	-	O	PTHR18916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	1	1.000	-	-		X2251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860