DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLIP-190 and MYH2

DIOPT Version :10

Sequence 1:NP_001368962.1 Gene:CLIP-190 / 35042 FlyBaseID:FBgn0020503 Length:1795 Species:Drosophila melanogaster
Sequence 2:NP_060004.3 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens


Alignment Length:1374 Identity:306/1374 - (22%)
Similarity:591/1374 - (43%) Gaps:329/1374 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 LSSSITTSTSTRPTIAAATAAAAAAAAC-----NRQPLQQQQQPHLHQKQ-----------QQAK 498
            |:..:|...||.|..          ..|     .:.|...:.:..|||.:           ::..
Human   661 LNKLMTNLRSTHPHF----------VRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGF 715

  Fly   499 PKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSID----EAQFCGDELNAQSQVY---- 555
            |.::.:.|.|:.:.:.......|....:.:|.:|:|..|||    :.:|      ..::|:    
Human   716 PSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKF------GHTKVFFKAG 774

  Fly   556 ----KEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQ 616
                .|::.|  .|:.:|::.|              ....:..:|:::.:..::::|....|...
Human   775 LLGLLEEMRD--DKLAQLITRT--------------QARCRGFLARVEYQRMVERREAIFCIQYN 823

  Fly   617 LEEEQRLRE--------NVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELE-----LL 668
            :.....::.        .:|.|.:...| :.|:.:..|..:|........|..|:|||     ||
Human   824 IRSFMNVKHWPWMKLFFKIKPLLKSAET-EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLL 887

  Fly   669 KEENEKQAQ-EAQAEFTRKLAEKSVEVLRLSSELQ-NLKATSDSLESERVNKTDECEI---LQTE 728
            ||:|:.|.| :|:||......|:..::::...:|: .:|..::..|       ||.||   |..:
Human   888 KEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE-------DEEEINAELTAK 945

  Fly   729 VRMRDEQIRELNQQLDEV-TTQLNVQKADSSALDDMLRLQKEG----------TEEKSTLLEKTE 782
            .|..:::..||.:.:|:: .|...|:|...:..:.:..|.:|.          |:||..|.|..:
Human   946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010

  Fly   783 KEL--VQSKEQAAKTLND-KEQLEKQISDLKQLAEQEKLVR--------------EMTENAINQI 830
            :.|  :|::|....||.. |.:||:|:.||:...||||.:|              ::.:.:|..|
Human  1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDI 1075

  Fly   831 QLEKESIEQQLALK-------QNELED-------FQKKQSESEVHLQEI------------KAQN 869
            :.||:.::::|..|       |:::||       .|||..|.:..::|:            ||:.
Human  1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140

  Fly   870 TQKDF--ELVESGESL---------------------KKLQQQLEQKTLGHEKLQAALEELKKEK 911
            .:.|.  ||.|..|.|                     :|:::.||:.||.||...|.|.  ||..
Human  1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR--KKHA 1203

  Fly   912 ETIIKEKEQ--ELQQLQSKSAESESALKVVQVQLEQLQQQA-AASGEEGS--KTVAKLHDEISQL 971
            :::.:..||  .||:::.|..:.:|.:|   ::::.|.... ..|..:|:  |....|.|::|:|
Human  1204 DSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265

  Fly   972 KSQAEETQ---SELKSTQSNLEAKS-------------------------KQLEAANGSLEEEAK 1008
            ||:.||.|   ::|.:.:..|:.:|                         :|:|.....||||.|
Human  1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330

  Fly  1009 ----------KSGH----LLEQITKLKSEVGETQAALSSCHTDV-------------------ES 1040
                      .|.|    |.||..:.:....|.|.|||..:|:|                   |:
Human  1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395

  Fly  1041 KTK---QLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSS--SALHTKLSK 1100
            |.|   :|:||...:|.||.:.|........||::|:::.      |..||:::  :||..|...
Human  1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM------LDVERTNAACAALDKKQRN 1454

  Fly  1101 FSDEIATGHKELTSKADAWSQEMLQKE-----KELQELRQQLQDSQDSQTKLKAEGERKEKSFEE 1160
            | |:|....|:...:..| ..|..|||     .||.:::...::|.|....||    |:.|:.::
Human  1455 F-DKILAEWKQKCEETHA-ELEASQKEARSLGTELFKIKNAYEESLDQLETLK----RENKNLQQ 1513

  Fly  1161 SIKNLQEEVTKA--KTENLE-LSTGTQTTIKDLQERLEITNAELQHKE-----------KMASED 1211
            .|.:|.|::.:.  :...|| :....:....:||..||...|.|:|:|           ::.||.
Human  1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578

  Fly  1212 AQKIADLKTLVEA-----IQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMN---- 1267
            .:|||:....::.     |::..:..|..:||:.:..:.::.:|....   :|.|||..:|    
Human  1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG---DLNEMEIQLNHANR 1640

  Fly  1268 ----SERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQ 1328
                :.|......||   ||:|.:.||:..:..|:|:|:|...::....||.|       :.|::
Human  1641 MAAEALRNYRNTQGI---LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAE-------IEELR 1695

  Fly  1329 QSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLE---- 1389
            .:|::.:.|.|..|:.:.:..|:|:    ::..|||.|..:..:||...|.::...:.:|:    
Human  1696 ATLEQTERSRKIAEQELLDASERVQ----LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARN 1756

  Fly  1390 SQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQ 1454
            :::|.|:...:||.::.||::.|:.:..::.....:|:.||.|:.:|..| .|| |.:...|::|
Human  1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA-EQL-ALKGGKKQIQ 1819

  Fly  1455 ELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1519
            :|..:.:|.||.::.|           ::.|.|..:.|.:.|..:|||..:.:|       .:|:
Human  1820 KLEARVRELEGEVESE-----------QKRNAEAVKGLRKHERRVKELTYQTEE-------DRKN 1866

  Fly  1520 HNEIQDKLEQAQQKERTLQEETSKLAEQ----LSQLKQANEELQKSLQQKQLLLEKGNEFDTQLA 1580
            ...:||.:::.|.|.::.:.:..:..||    |::.::...||:::.::..:...:.|:...:..
Human  1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSR 1931

  Fly  1581 E-YQKVIDE 1588
            | :.|||.|
Human  1932 EVHTKVISE 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIP-190NP_001368962.1 PHA03307 <2..>118 CDD:223039
CAP_GLY 125..189 CDD:460154
CAP_GLY 239..306 CDD:460154
SMC_prok_B <546..912 CDD:274008 102/468 (22%)
SMC_prok_B 743..1596 CDD:274008 243/1035 (23%)
COG4913 <1534..>1703 CDD:443941 11/60 (18%)
CLIP1_ZNF 1726..1743 CDD:465212
CLIP1_ZNF 1773..1789 CDD:465212
MYH2NP_060004.3 Myosin_N 33..77 CDD:460670
MYSc_Myh2_mammals 100..772 CDD:276877 22/126 (17%)
Actin-binding. /evidence=ECO:0000250 661..683 6/31 (19%)
Actin-binding. /evidence=ECO:0000250 763..777 2/19 (11%)
Myosin_tail_1 852..1929 CDD:460256 268/1137 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 1/18 (6%)
Blue background indicates that the domain is not in the aligned region.

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