DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and zgc:103755

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_001349445.1	Gene:	zgc:103755 / 449988	ZFINID:	ZDB-GENE-041010-101	Length:	733	Species:	Danio rerio

Alignment Length:	394	Identity:	117/394 - (29%)
Similarity:	164/394 - (41%)	Gaps:	114/394 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IPQPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPP----PREATS-MSRESDDNLSSINSAYT 109
            :|:|..|  |.........:|..|.......|:...|    |..... :|.::...|||:.
Zfish   247 VPEPLDM--PLEIADAAVQAKELRTLLQEVLPRPDAPLSLLPTPPLGVLSDKARTQLSSMG---- 305

  Fly   110 DNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYF 174
                         ..:|.:|.:.|.:.|.:.|.|.|.||.|.||||.|.:|.|||||.|:|.:||
Zfish   306 -------------LHLGDKVVIAGQKVGSLRFCGSTEFAGGLWAGVELQQPVGKNDGSVAGVQYF 357

  Fly   175 QCEPKRGIFSRLTRL-------------TTYP-------------------------------LA 195
            .|..|.|||:.|:::             |..|                               |.
Zfish   358 TCPIKHGIFAPLSKISKLSEHRKHSPRQTCVPVPHPRRIDLARVTSKVNTGLLSRSCSTSSSSLD 422

  Fly   196 GAQT---PTSPLAKS-------------------SPDRSRTVSPTASIRSSM--LRSPGIGGKNG 236
            ..||   |..||.:.                   :|.||.|.:|.:.|..|.  |.|........
Zfish   423 SRQTSRRPPRPLPRQRPPLHPWQERVAPSTRSTPAPSRSHTSTPHSIIARSRTPLASSTAHESPE 487

  Fly   237 MAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV 301
            :.:|:||:|   .|.|.|::|:.|:|.||||.|.|:|||:|.|||||:|..:|||.|.||:|||.
Zfish   488 VHLGERVLV---VGQRTGVVRFYGKTSFAPGFWLGIELDKPGGKNDGSVGGVRYFSCPPKHGVFA 549

  Fly   302 PIAKVS--------LSP-SSKKTRLSRTGSRESLTSIGTMNSIAT-------TATSRMRMNAQQR 350
            |.::|.        ||. ||.:...|.||.|.:.:   |.::|||       :..||.|.|..:|
Zfish   550 PPSRVQRIHGSVDCLSELSSSRMNYSFTGIRRTFS---TSSAIATQREPSRKSQASRNRSNNLRR 611

  Fly   351 KSST 354
            :.||
Zfish   612 RWST 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	13/72 (18%)
		CAP_GLY	125..189	CDD:396049	31/63 (49%)
		CAP_GLY	239..306	CDD:396049	36/66 (55%)
		SMC_prok_B	<546..912	CDD:274008
		Smc	734..1591	CDD:224117
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
zgc:103755	NP_001349445.1	ANK	121..246	CDD:238125
		ANK repeat	129..166	CDD:293786
		ANK repeat	173..204	CDD:293786
		ANK repeat	206..237	CDD:293786
		CAP_GLY	308..372	CDD:307465	31/63 (49%)
		CAP_GLY	490..554	CDD:307465	36/66 (55%)
		CAP_GLY	653..718	CDD:307465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910