Protein Alignment CLIP-190 and dctn1

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: XP_012811215.1
• Gene: dctn1 / 447948
• XenbaseID: XB-GENE-5933522
• Length: 1296
• Species: Xenopus tropicalis
• Alignment Length: 1637
• Identity: 350/1637 - (21%)
• Similarity: 618/1637 - (37%)
• Gaps: 503/1637 - (30%)

  Fly   200 PTSPLA--KSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRV-IVSSGFGSRPGILRYLGE 261
            ||.|::  .|....|...:|::|.|.|:..:    || .:.||.|| ::..|:   .|.:.|:|.
 Frog     9 PTRPVSWRSSLGGVSARETPSSSARMSVEAT----GK-PLKVGSRVEVIGKGY---RGTVAYVGA 65

  Fly   262 TQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESL 326
            |.||.|.|.||.||:..|||||||...|||.|:..:|:||..:::.:......|
 Frog    66 TLFATGKWVGVILDDSKGKNDGTVQGRRYFTCEENHGIFVRQSQIQVIEDGADT----------- 119

  Fly   327 TSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDR 391
                                      ::|..|..|..|.
 Frog   120 --------------------------TSPETPEPAASKG-------------------------- 132

  Fly   392 EDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITT 456
                     |:|:::|.           |.:.:.|..:|.|             .|||...:...
 Frog   133 ---------LKKDVSET-----------PKSSKLRGVKPKK-------------APTTRKITTRR 164

  Fly   457 STSTRPTIAAAT-----AAAAAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKAR 516
            :..|||:.:||:     |:.:|:|:|......:...|                    ...||.|.
 Frog   165 TKPTRPSSSAASSGTAGASGSASASCGEISSSEPSTP--------------------AQTPLAAP 209

  Fly   517 IVELESAL----------DNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVS 571
            |:...|:.          ....|:.|.|:..:       .:|:.:.:..|.|..:.::|:.:|..
 Frog   210 IIPSPSSAILSPVAPLPGPGPTKEEENLRAQV-------KDLDEKLETLKMKRAEDKAKLKELEK 267

  Fly   572 ATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAE-QLEEEQRLRENVKYLNE--- 632
            :...|:.            |||..:|:||    ||.:|:.::.| :.|.::.|....:|:.|
 Frog   268 SKLQLEQ------------LQEWKSKMQE----QQADVQRQLKEAKKEAKEALEAKERYMEEMAD 316

  Fly   633 -----QIATLQSELV-SKDEAL-EKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEK 690
                 ::|||..|:. .:.|:| ::....:..:|.|:.:||:.|.|.|::..:.        |..
 Frog   317 TADAIEMATLDKEMAEERAESLQQEVDTLKDKVEELKIDLEIFKHEIEEKGSDG--------AAS 373

  Fly   691 SVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKA 755
            |.:|.:|..:...||                    :..|||||   ...:::.:.|..|..::|.
 Frog   374 SYQVKQLEEQNARLK--------------------EALVRMRD---LSASEKQEHVKVQKQMEKK 415

  Fly   756 DSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQ----E 816
            ::..  |.||.|||..:|:::|:|||..||   |||....|..:|.:|       .|.|:    |
 Frog   416 NTEL--DTLRQQKEKLQEEASLMEKTIDEL---KEQVDAALGAEEMVE-------TLTERNLDLE 468

  Fly   817 KLVREMTE-----NAINQI--QLEKESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQNTQKD 873
            :.|||:.|     .|||::  :|::.:.|.:|.|: |.::...:.:::|..|.    .||.|..|
 Frog   469 EKVRELRETVSDLEAINEMNDELQENARETELELREQLDMAGARVREAEKRVE----AAQETVAD 529

  Fly   874 FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQ---ELQQLQSKSAESESA 935
            ::     :::||.:.     ...|  ||....||:.::|..:::::|   |:...:.|.||:::.
 Frog   530 YQ-----QTIKKYRD-----LTAH--LQEVNRELRNQQEASVEKEQQPSPEMFDFKIKFAETKAH 582

  Fly   936 LKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEET---------------------- 978
            .|.::::|.:::             |::.:..:|.|.|...::
 Frog   583 AKAIEMELRKME-------------VSQANRHVSLLTSFMPDSFLRHGGDHDCILVLLLIPRLIC 634

  Fly   979 QSELKSTQS----NLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVE 1039
            ::||.|.|:    .|...|:|.....|::.|:...:..|:..:|.|::.:.:.:.||..|..:|.
 Frog   635 KAELISKQAQEKFELSEASEQKSGMRGAVGEQMSFAAGLVYSLTLLQATLHKYEQALDKCSVEVY 699

  Fly  1040 SKTKQL--------EAANAALEKVNKEYAESRAEASDLQDKVK--EITDTLHAELQAERSSSSAL 1094
            .|...|        .:.:..:|.::|:..:.......|...:|  :...::|...|:|..:
 Frog   700 KKVGMLYPEMSVHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLADQSEECT---- 760

  Fly  1095 HTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQL---QDSQDSQTKLKAEGERKEK 1156
                .:.||.|    |...|..|...       .|:..||..|   |:|.|....|        |
 Frog   761 ----MQLSDHI----KFTQSALDCMG-------VEVSRLRAFLHVGQESSDFAILL--------K 802

  Fly  1157 SFEESIKNLQEEVTKAK-----TE------NLELSTGTQTTIKDLQERLEITNAELQHKEKMASE 1210
            ..|.|..::::...|.:     ||      .|..:.....|:.|.::.|:...|..|   ::|:.
 Frog   803 DLETSCSDIRQFCKKIRRRMPGTEAAGIPAALSFAQPVCETLLDCRKYLKCVVAVFQ---EVAAA 864

  Fly  1211 DAQKIADL--KTLVEAIQVANANISAT----NAELSTVLEVLQAEKS---ETNHIFELFEMEADM 1266
            .||.||.:  ...::|:::.:....||    .::.|...|.|:...|   .|.:.......|.:.
 Frog   865 GAQMIAPMGENEGLQALKLEDVAFKATEQIYGSKGSNPYECLRQSCSVVIATMNKMATAMQEGEY 929

  Fly  1267 NSER--------LIEKVTGIKEELKETH---LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTS 1320
            ::|:        :.::...::.|:.:..   |:|::|:...:||::.||              ..
 Frog   930 DAEKPQSKSPPPVEQRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK--------------IK 980

  Fly  1321 KEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQD 1385
            .|:|:|....|..|:          :.|:...:|:...:|...|||.|:...|:.|....:||.|
 Frog   981 GEELSEANVRLSLLE----------KKLDSASKEADDRVEKIQTKLEETQTVLKKKEKEFEETMD 1035

  Fly  1386 QLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATN 1450
            .|   |....||:.|.|:|.      |..|...|.::           |.|:.:.:...|...:.
 Frog  1036 AL---QADIDQLESEKAELR------QRLNNQSKRTI-----------EGLRGSPASGVASIVSG 1080

  Fly  1451 KELQELLVKSQENEGNLQGESL-----AVTEK-----LQQLEQANGELKEALCQKENGLKELQGK 1505
                  |...:|..|...|:||     .|..|     |||::.....:|. |..:.|.||..|.|
 Frog  1081 ------LAGEEEQRGVSSGQSLLNGSGPVQVKDSPLLLQQIDALRLSMKH-LKHENNKLKAHQIK 1138

  Fly  1506 LD-ESNTVLESQKKSHNEIQDKLEQAQQKER----TLQEETSKLAEQLSQLKQANEELQKSLQQK 1565
            .| .|...|...|.|       |.:.:|:|.    ||..:||:|.:.|.|: .||
 Frog  1139 ADLASLPALHVPKLS-------LPKDRQREEALSGTLYRKTSQLLDALQQM-SAN---------- 1185

  Fly  1566 QLLLEKGNEFDTQLAEYQKVID-EMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETK 1629
                             .||:| ....|.|....||||                    ||.|  |
 Frog  1186 -----------------AKVVDIAHKKAGSPAVHLLEQ--------------------TARL--K 1211

  Fly  1630 ELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDA 1694
            .|...::.|:.|..:|.:   ||..||             ::.|..|.....:.|.|..::|.|.
 Frog  1212 SLSDTIDKLKDEVMKETV---AQCPGA-------------NVPTDFATFPSSDFIKAKEEKKEDT 1260

  Fly  1695 LKAKVQTLETLP 1706
            :.....||...|
 Frog  1261 VYIGKVTLSCQP 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:460154
		CAP_GLY	239..306	CDD:460154	31/67 (46%)
		SMC_prok_B	<546..912	CDD:274008	94/388 (24%)
		SMC_prok_B	743..1596	CDD:274008	206/953 (22%)
		COG4913	<1534..>1703	CDD:443941	38/173 (22%)
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212
dctn1	XP_012811215.1	CAP_GLY	45..110	CDD:460154	31/67 (46%)
		SMC_prok_B	<229..535	CDD:274008	90/380 (24%)
		Dynactin	544..822	CDD:463591	59/317 (19%)
		EnvC	982..>1187	CDD:443969	65/276 (24%)