Protein Alignment CLIP-190 and Dred

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: NP_649124.1
• Gene: Dred / 40124
• FlyBaseID: FBgn0036882
• Length: 1339
• Species: Drosophila melanogaster
• Alignment Length: 1616
• Identity: 356/1616 - (22%)
• Similarity: 611/1616 - (37%)
• Gaps: 419/1616 - (25%)

  Fly   125 IGQRVWLGGTR-PGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSR--- 185
            :||||.:.|.. .|::|::|.|:||||.|.|||||||.|||:|.|.|..||:|....|:|.|
  Fly     9 LGQRVEVTGKNLQGKVAYVGRTNFAAGLWYGVVLDEPLGKNNGSVHGSIYFKCPTNCGLFVRAQQ 73

  Fly   186 LTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFG 250
            |.|:...|..|.......:.:.            ..|:.:.|..|    :|.:|.::........
  Fly    74 LVRIAELPKGGDNRKADEMQRD------------GARAKLSRRSG----SGKSVEEQDNQREQQA 122

  Fly   251 SRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKT 315
            |..|.::....|            ..|..||..|                         .||.:|
  Fly   123 STSGKVKATSST------------PSPQHKNRNT-------------------------HSSMET 150

  Fly   316 RLSRTGSRESLTSIGTM----NSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREK 376
            .|::|..:...|....:    |.:  |..|.:| |:|.:::.    .:..:||....::...:..
  Fly   151 SLAKTSGKFLATHQQPLQLPKNPV--TCESSVR-NSQSKETG----EVTLSPKKSSDIEQSKKHS 208

  Fly   377 QQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQ 441
            ||...:.......:.|......||..:..|.::   ||...||..:...: ..|.|.|....|.
  Fly   209 QQETNETNQPASKEVEPKNENELQSTEAANSML---DTPVNPLQTSTIGQ-LPPQKASAQLTPP- 268

  Fly   442 QHIWVPTTLSSSITTS---------TSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQA 497
                 |.|.:...:||         :..:||.|.|.::.|........||             ..
  Fly   269 -----PLTCNQRRSTSYTQLRPTRISQPKPTTAQAQSSTAQLTLAMPVPL-------------AL 315

  Fly   498 KPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFC-GDELNAQSQVYKEKIHD 561
            .||:    .|..:.|..: |..:..|...|.:..|.|:     .||. |..|.
  Fly   316 APKR----SKTSMSPTSS-IKRVAPAAFVEPRFLEILR-----PQFTPGPALR------------ 358

  Fly   562 LESKITKLVSATPSLQSILPP-DLPSDDGALQEEIAKLQEKMTI---QQKEVESRIAEQLEEEQR 622
                       |||  |:.|| |.|        |:.:|:|::.:   |:.|.:.::.|
  Fly   359 -----------TPS--SVAPPLDNP--------ELRQLREELQLLRGQKSEDKLKLLE------- 395

  Fly   623 LRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKL 687
             .|.::..|||:...:|:::::...|:             |||:..:.| .::||:..::..|:|
  Fly   396 -LERMRIHNEQLMEFKSQIMAQQVLLQ-------------RELQRSRHE-LREAQDVSSKLKREL 445

  Fly   688 AE--KSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQL 750
            .|  :|:|:|.|..|:...:..:..:|.|...:.::...|..|: ::.||..:..|::::...|:
  Fly   446 DEIAESIELLTLDKEMAEERMETLQMELEMAQERNDELSLDVEI-LKAEQEEQQGQRIEKSEKQI 509

  Fly   751 NVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQ 815
            .....:.|| .:.|||::.....:.|:: :....|.:.|:...:|..:.|....:|::||.:.|
  Fly   510 GSGVTNQSA-GEFLRLEQYNQRLRETVV-RLRDTLAEEKQIGQRTHKELETKHSEINELKSIKE- 571

  Fly   816 EKLVREMTENAINQIQLEKESIE---------QQLALKQNELEDFQKKQSESEVH----LQEIKA 867
              |:....:|...|:...||.::         .|||..:.|||| :.|..|.||:    |::|:.
  Fly   572 --LLSRRVDNMEMQLMDLKEQVDASLGAEAMVTQLASLKLELED-RVKLLEDEVNELEALEQIQE 633

  Fly   868 QNTQKDFELVESGESLK-KLQQQLEQKTLGHEKL-----QAALEELKKEKETIIKEKEQELQQLQ 926
            |       |:||.:.|: .|::::: |..||.|:     .||:|.|.....||:|.::. ::|||
  Fly   634 Q-------LIESNQELETDLREEID-KLSGHVKILEQQKNAAMESLYDRDVTIMKFRDL-VRQLQ 689

  Fly   927 SKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 991
                             ||||.:|     :|:.::   .|..|..:||.|:..::.::...::.:
  Fly   690 -----------------EQLQLRA-----DGTLSI---EDFSSANESQQEDGSNQSQTDYQHIFS 729

  Fly   992 KSKQLEAANGSLEEEAK------KSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANA 1050
            .||   |...:||::.|      :..| ||.:.....|    |..|.....||......||..|.
  Fly   730 VSK---AYGRALEQQIKTVELRLQRQH-LEHVLAFVPE----QFLLRGGEHDVVLVMLLLERMNE 786

  Fly  1051 AL----EKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSS----SALHTKLSKFSDEIAT 1107
            .|    :.:|:::..:.....|      .|.:....:....||..    .:|...|.:|...:..
  Fly   787 KLTIVCQAINEKFPTACEFGRD------AIFEGYSVQRYIFRSQCLYLLKSLQLVLQQFRHGLTH 845

  Fly  1108 GHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKA 1172
            ...||.:.|..:..::               |:|:.|                    |.|.|...
  Fly   846 CDYELCTHAAIYRSDL---------------DAQEQQ--------------------LDEFVRLL 875

  Fly  1173 KTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEA-IQVANANISATN 1236
            ||..|:    ..|..:.:|..|...:.  .|:..|..:...::.|.:.|.|| |:|..|.:.|.|
  Fly   876 KTGQLD----EHTNCEPIQRVLHYVSG--LHQNLMPPQTLVELLDEQQLYEALIEVYEAGLDAVN 934

  Fly  1237 AELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLD----------- 1290
            |....:..::|....:|.. |...:|        |:|:....|::||:...:|.
  Fly   935 ANAGLMHTIIQLGHEQTAS-FSCMQM--------LMEQSCAHKQKLKKLQRKLSGSKTASWTGMQ 990

  Fly  1291 -ERQKKFEELEE------KLKQAQQSEQKLQQESQTSKEKLTEI----------QQSLQELQDSV 1338
             .|.::..|..|      :|......|.........:.|||..:          .|..:|.::..
  Fly   991 CARYQRIMEANEALGTLIRLLGCTAREASKDSNGGIAHEKLWRMLVLNYNKFAPSQEAEEPREVD 1055

  Fly  1339 KQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAK 1403
            ...:..:|.|||:..|..:::::     .:.|.:.....:|               ..|||.||
  Fly  1056 AYSQRCMQLLEEQFDELFALLDS-----TDVNTEYVRHPTC---------------NTLQERAA- 1099

  Fly  1404 LSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNL- 1467
                  ||:....|:|:..:.|.|..|  |.|....|:::..|     :..||.|:.:..|..|
  Fly  1100 ------QVKRHYEDVKNLELTVAEREK--EIKSLKYTAKMKQQ-----DYSELQVRKEMAEKQLS 1151

  Fly  1468 -QGESLA-VTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQA 1530
             |...|| ..|.::||||       ::..||..|.:....|.:..|.|| |.:.|.:     ||.
  Fly  1152 KQCHVLAGFAEAVEQLEQ-------SILAKEAALGQALNMLADKLTSLE-QSQEHWK-----EQQ 1203

  Fly  1531 QQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASV 1595
            |.....|...|.....:::.|.||       |:|     |:....:.|.:|.:|..
  Fly  1204 QADSACLTSTTISSNREMNMLHQA-------LRQ-----ERSLRVELQGSEMRKTF--------- 1247

  Fly  1596 KSALLEQL------QNRVAELETALRQANDAQKTAYLETKELRRQLES-LELEKSR 1644
              |.||.|      ...:.:||..||...:....|:||.....||..| :||:.||
  Fly  1248 --AALEPLHVPQAGSQELTDLEKDLRSLKNQWLLAHLEMGAAGRQRRSEIELQGSR 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:460154	34/67 (51%)
		CAP_GLY	239..306	CDD:460154	8/66 (12%)
		SMC_prok_B	<546..912	CDD:274008	89/390 (23%)
		SMC_prok_B	743..1596	CDD:274008	196/917 (21%)
		COG4913	<1534..>1703	CDD:443941	29/118 (25%)
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212
Dred	NP_649124.1	CAP_GLY	9..74	CDD:460154	33/64 (52%)
		Metaviral_G	171..306	CDD:462833	31/151 (21%)
		Smc	<373..>704	CDD:440809	91/393 (23%)
		Dynactin	688..967	CDD:463591	72/367 (20%)
		Smc	<1092..>1305	CDD:440809	70/260 (27%)