DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Ccdc27

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_030109499.1	Gene:	Ccdc27 / 381580	MGIID:	2685881	Length:	736	Species:	Mus musculus

Alignment Length:	775	Identity:	162/775 - (20%)
Similarity:	293/775 - (37%)	Gaps:	205/775 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 LKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATS-DSLESERVNKTDECEILQTEVRM 731
            :|:||          .|::....|.::.:....||::.:.. |:.:||:..::.:..:.::....
Mouse    48 MKQEN----------LTQECCSTSPKISKGLMVLQSIASRGCDTQDSEKKPQSTQQSLKKSSQAA 102

  Fly   732 ------RDEQIRELNQQLDEVTTQLNVQKADSSALDDMLR--LQKEGTEEKSTLLEKTEKELVQS 788
                  :::|||:|::           .....|.::||.:  |.:.|..:.||  ..|....|.|
Mouse   103 AGYFYDKEDQIRKLSK-----------HNGFLSEMEDMRKAFLMRPGCPQFST--RTTSMSHVGS 154

  Fly   789 KEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAIN--QIQLEKESIEQQLALKQNELEDF 851
            ....        .|.:..|.:.:|.|...|.|..:.::::  .....|.:.|.....|::|..|.
Mouse   155 AIMV--------DLPRTCSGVWKLTEDHPLGRLGSASSVDGRVFPFSKSACELNYPRKRSEPSDP 211

  Fly   852 QKKQSESEVHLQEIKAQNT----------QKDFELVESGESLKK---LQQQLEQKTLGHEKLQAA 903
            ....|.:.|.    |:|.|          :||..|:..||.|::   ::.|:::|......||..
Mouse   212 SPTGSPTVVK----KSQRTRTPWYISVIHEKDHSLLLMGEELQRFSEMESQMQKKDQEILTLQKE 272

  Fly   904 LEELKKEKETIIKEKEQELQQLQSKSAES-ESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDE 967
            .|.|||:.:.:::.|..|......|...| |:.||:.::.:              .||:.|..||
Mouse   273 KEALKKQLKNLLRGKGTETSSASIKMDRSFETPLKLGRMSV--------------LKTIYKEEDE 323

  Fly   968 ISQ-LKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAAL 1031
            :.. ::.|.|.:.:|          .||:|....||..||  ||           ||....:||.
Mouse   324 LQHWMQMQEEYSMAE----------SSKELHVEPGSAIEE--KS-----------SEGPPEEAAA 365

  Fly  1032 SSCHTDVESKTKQL------EAANAALEKVNKEYAESRAEASDLQDKVK---------------- 1074
            :......:|||:.|      |......|:|..:.|:...|...|.::.:
Mouse   366 AKLSRPSQSKTETLLEVGPEEEEEEEEEEVEGDEAKGTEEGEILVNEEEASWELREDEECHPKRS 430

  Fly  1075 -EITDTLHAELQAERSS--------SSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK---- 1126
             .:|::...||.|:...        ...|....|::|  :|||......:...:.:..|:|
Mouse   431 YSMTESFEEELMAQLEEYERMLMDFQRELEFTRSRYS--LATGTITSLQRQTDFQESQLRKVTTE 493

  Fly  1127 ----EKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEE--VTKAKTENLELS-TGTQ 1184
                ||||:|.:||:||..|..:.|     |:||..:|.:..:::|  |.:.:..:|::. ..::
Mouse   494 NELLEKELRERKQQIQDMTDKFSNL-----REEKKHQEIMGLIEKENLVLRQQVADLKMDLISSE 553

  Fly  1185 TTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQA- 1248
            .|||:|       |.:.:..|...:.|...:...|.|.:.:|..|..|..|..:...|||..||
Mouse   554 RTIKEL-------NTQTKELEDQVNTDKDHLRRWKDLHDDLQTRNEIIQQTEQQTRVVLEATQAR 611

  Fly  1249 -EKSETNHIFELFEMEADMN------SERLIE--KVTGIK------------------------- 1279
             ||.....|..:|.:..:.|      ...::|  :|.|:|
Mouse   612 YEKLRNKIIQAVFSVSGNKNLSMELSDSYILESLQVRGVKLCSPPEAEGRGEAWTHGNPALILPM 676

  Fly  1280 -------EELKETHLQL------DERQKKFEELEE---KLKQAQQSEQKLQQESQTSKEK 1323
                   ..:.||.|.|      .||...:.:|::   |:...|||:..|..:.:....|
Mouse   677 PSMHCNPRTVLETRLSLGIARIISERSDFYSQLKQKGVKVPPLQQSDVSLPSKIKKMASK 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008	54/267 (20%)
		Smc	734..1591	CDD:224117	152/702 (22%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
Ccdc27	XP_030109499.1	SMC_prok_A	<400..>639	CDD:274009	56/252 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000