Protein Alignment CLIP-190 and Khc-73

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1443
• Identity: 284/1443 - (19%)
• Similarity: 501/1443 - (34%)
• Gaps: 447/1443 - (30%)

  Fly   519 ELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPD 583
            :|.||:.|  |.|.||...::.:..         ::|.||:||       |:...|:.||:...:
  Fly   126 QLFSAIAN--KSTPELMYKVEVSYM---------EIYNEKVHD-------LLDPKPNKQSLKVRE 172

  Fly   584 L----PSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLE---EEQRLRENVKYLNEQIATLQSEL 641
            .    |..||..|..:...|:...:..:..:||......   |..|.......:..||.|.|:..
  Fly   173 HNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATG 237

  Fly   642 VSKDEALEKFSL-----SECGIE------------NLRRELELL--------------KEENEKQ 675
            || .|.:.:.||     ||..::            |:.:.|..|              |..|:|.
  Fly   238 VS-GEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKF 301

  Fly   676 AQEAQAEFTRKLAE------KSVEVLRLSSELQNLKATSDSLE-SERVNKTDECEILQTEVRMRD 733
            .....:..|..|.:      ::|.|..:|....|.:.|..:|. ::|..:.....::..:...|
  Fly   302 VPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR- 365

  Fly   734 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLND 798
             .||||..:::.:.:.|  :.|..|.:.|                       ||.|      |.:
  Fly   366 -IIRELRHEVETLRSML--KHATGSPVGD-----------------------VQDK------LAE 398

  Fly   799 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQ--LEKESIEQQ---LALKQNE--LEDFQKKQS 856
            .|.|.||||.    ..:||||:  ||...|:.|  |||..|..|   :.:::|:  |.:.....|
  Fly   399 SENLMKQISQ----TWEEKLVK--TERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPS 457

  Fly   857 ESEVHLQEIK---------AQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQ---------AA 903
            .:|:.:..:|         ....|.|.:|...|...:.....:|...|..|.:|         ||
  Fly   458 LNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAA 522

  Fly   904 LEEL---------------------KKEKETIIKEKEQELQQL------QSKSAESESALKVVQV 941
            :|:.                     |....::...:.|...||      :.:..::|.:...:|.
  Fly   523 VEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQT 587

  Fly   942 QLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAA------N 1000
            .:.:|::|     .|..|.||        |:.|.:|.:.:.:..::.|...:.....|      .
  Fly   588 AIARLERQ-----HEEDKQVA--------LEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRM 639

  Fly  1001 GSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE 1065
            |.:......|...:|:..:.:.|:  .:.:|....||:......::.||...|::.|:
  Fly   640 GKITPNTPTSQMRVEKWAQERDEM--FRRSLGQLKTDIMRANSLVQEANFLAEEMEKK------- 695

  Fly  1066 ASDLQDKVKEITDTLH---AELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKE 1127
                    .:.:.||.   |.|...|        :...|..|.|...|...|.:..|:.|.|  |
  Fly   696 --------TKFSVTLQIPPANLSPNR--------RRGAFVSEPAILVKRTNSGSQIWTMEKL--E 742

  Fly  1128 KELQELRQQLQDSQDSQTK-LKAEGERKEKSFEES--------IKNLQEEV----------TKAK 1173
            .:|.::|:..|:.::.... |..:..:.:..|.||        :.|:..||          |...
  Fly   743 NKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPII 807

  Fly  1174 TENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLK--------------TLVEA 1224
            ::..|::...|..|    ||:    |....:::|....::...|.:              |....
  Fly   808 SQQGEVAGRLQVEI----ERI----AGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVT 864

  Fly  1225 IQVANA-NISATN---------AELSTVLEVLQAEKS--ETNHIFELFEMEADMNSERLIEKVTG 1277
            |:.|:. .:|.:|         .....|:.|:.||.:  :.|.:|: ||...|..       ||
  Fly   865 IKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK-FEHTQDFT-------VT- 920

  Fly  1278 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1342
            |.||.                ||..::.|...|....:.:..||.|..|::|...:.:..|.:..
  Fly   921 INEEF----------------LEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWA 969

  Fly  1343 ELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGE 1407
            ||.:.:|..|.     |...|.....|.|::.|:...|.....||.:.|::...::.:..:.||.
  Fly   970 ELSRKIELWVE-----IHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGT 1029

  Fly  1408 LQQVQEANGDIKDSLVKV------------EELVKVLEEKLQAATSQLDAQQATNKELQELLVKS 1460
            |..:.::..::....|.|            ||.:.||.||...|..:  .:|..::::|.|:.|.
  Fly  1030 LPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGR--RRQYLDQQIQMLIKKE 1092

  Fly  1461 QENEG-----------------------------------------------------NLQGESL 1472
            ::||.                                                     ||.|:.|
  Fly  1093 EKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDL 1157

  Fly  1473 AVTEKLQQLEQANGELKEA----LCQKENGLK----ELQGKLDES-----------------NTV 1512
            :.       :..|.||..|    :..||:|.|    ::...||:.                 |.|
  Fly  1158 SA-------QNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRV 1215

  Fly  1513 LESQKK-----------SHNEIQD-----KLEQAQQKERTLQEETSKLA---------------E 1546
            .|:.::           ||....|     :|....:|.:||.:...|..               |
  Fly  1216 TEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYE 1280

  Fly  1547 QLSQLKQANEELQ--KSLQQKQLLLEKGNEF-----DTQLAEYQKVIDEMDDAASVKSAL-LEQL 1603
            .:|.:.:|:|||:  :||.|   |...|::.     :|.:.:|.:.:      ::|:|.| |::|
  Fly  1281 VVSNIPKASEELEDRESLAQ---LAASGDDCSASDGETYIEKYTRGV------SAVESILTLDRL 1336

  Fly  1604 QNRVA--ELETALRQANDAQKTA----YLETKELRRQLES-LELEKSREVLSLKAQMNG------ 1655
            :..||  |||||..|....:||.    :.:.......:|| |.:.:|.....|.....|
  Fly  1337 RQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPA 1401

  Fly  1656 ASSRSGKGDEVES 1668
            ..|.:|.|..:.|
  Fly  1402 GHSPAGAGGVIRS 1414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:460154
		CAP_GLY	239..306	CDD:460154
		SMC_prok_B	<546..912	CDD:274008	93/456 (20%)
		SMC_prok_B	743..1596	CDD:274008	202/1086 (19%)
		COG4913	<1534..>1703	CDD:443941	41/171 (24%)
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	52/251 (21%)
		Kinesin_assoc	356..468	CDD:465047	36/150 (24%)
		FHA_KIF13	446..547	CDD:438758	15/100 (15%)
		KIF1B	741..786	CDD:463574	9/46 (20%)
		DUF3694	989..1243	CDD:463599	45/262 (17%)
		CAP_GLY	1785..1850	CDD:460154