DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Ccdc187

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_808509.1	Gene:	Ccdc187 / 329366	MGIID:	3045295	Length:	958	Species:	Mus musculus

Alignment Length:	733	Identity:	129/733 - (17%)
Similarity:	215/733 - (29%)	Gaps:	292/733 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASGGTSAPFPSPVTADPEPGATAS-----------KLPGPIRSNIPTPATSGTGIPQPSK----- 55
            ||.|||||            ::||           |.| .:.:.:|.||..|:|:.:.::
Mouse   179 ASLGTSAP------------SSASCLYKTSTMLWRKTP-KVTNALPVPAFPGSGVLRTAEHRGKD 230

  Fly    56 ----------MKAPSSFGST--GSVSKIGRPCCNHTTPKSGPPPREATS---------------- 92
                      .|.|....|.  .:..|:....|.....||....|.|..
Mouse   231 RASLSLRRELSKVPQHHTSVPRTNFKKVKNASCKREISKSSILRRTAKGRGSDRKAAAVKASPAH 295

  Fly    93 ------MSRESDDNLS--SINSAYTDNSSAV-------------------------------LTA 118
                  ||..||..:|  :.:.|:.|.|:.:                               |:.
Mouse   296 TWLCKPMSAHSDQQVSKHTPSLAFQDQSATIHGAMETLQDLRQQIQAGLELTRSPRVDRKLSLSK 360

  Fly   119 NTEQFIIGQR----------------VW-LGGTRPGQIAFIGDTH--------FAAGE------W 152
            ...|.::|:|                .| :...:...:...|:.|        .|..|      |
Mouse   361 PKPQNLVGKRDRGLQSTQDMQGSSKTAWTVTEGKNSSLHRAGNLHSQQHRKKALAEHESCPRRTW 425

  Fly   153 AGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPL---------AGAQTPTSPLAKSS 208
            .|...|....:........|:|...|    :|.|.| .|||.         ...|...|.|.|.|
Mouse   426 TGQGQDSSFPRPGSTPEKPRFFSQRP----WSALAR-QTYPQRTWDAQGQDISVQKSGSSLKKPS 485

  Fly   209 PDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCG-- 271
            |...|..|             .:.|:...|..||.:                   |.|..|..
Mouse   486 PFSQRPWS-------------ALAGRAYSACEDREV-------------------FEPSPWNSLS 518

  Fly   272 --------------VELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLS-PSSKKTRLSRTG 321
                          |:...||.|....|.               |.:||..: |...:..|....
Mouse   519 RPHSALQDPWSNSFVQRSSPSSKGKSAVP---------------PPSKVKPAWPEPSQDLLQSKP 568

  Fly   322 SRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREK-----QQHVE 381
            ::|.           .|...|.|.:..|:.||.             |::|.:|:|     ||.:|
Mouse   569 AKEQ-----------DTPCPRPRGSLGQQHSSE-------------SLRDFMRQKAQARRQQALE 609

  Fly   382 -KLMVERDLDREDAQNQALQ-LQKNINEVIIFTDTMYAPLPYADRSRP----YRPSKKSRVKVP- 439
             |.:....|   :.:||.|| :.:...|.::..|     :|...:.||    :.|.:...::.|
Mouse   610 QKALAAHTL---ELRNQRLQEVYRKQREAVLGKD-----IPVVSQRRPGIVTFVPMQSGGMEAPG 666

  Fly   440 ----QQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQAKPK 500
                .::..|      |.:|:.     .:.....|..:...|..:|..:      .:.|...:|.
Mouse   667 SLGSPREQTW------SKVTSG-----MVLGDQEAPDSFCLCLNKPWNR------IETQDTGRPL 714

  Fly   501 KVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESK 565
            :.:         .:||:..||:..:..|::.:.|...:|:            ....:...||.|.
Mouse   715 EGY---------KQARLQALETMAEALRQRVDILTTKLDK------------PTSPDTSGDLASD 758

  Fly   566 ITKLVSAT-PSLQSILPP 582
            :..|..:| |:..:::||
Mouse   759 VLPLCPSTAPATPTLVPP 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	34/193 (18%)
		CAP_GLY	125..189	CDD:396049	15/94 (16%)
		CAP_GLY	239..306	CDD:396049	11/82 (13%)
		SMC_prok_B	<546..912	CDD:274008	8/38 (21%)
		Smc	734..1591	CDD:224117
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
Ccdc187	NP_808509.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..160
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..447		13/101 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..602		23/130 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..958
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900